A5100380555- CAR-T cell therapy research
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Healthcare and Venom Research
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Health disparities and outcomes
- Neonatal Respiratory Health Research
- Nutritional Studies and Diet
- Birth, Development, and Health
- Virus-based gene therapy research
- Nutrition, Genetics, and Disease
- Cardiovascular Health and Risk Factors
- Health, Environment, Cognitive Aging
- Polysaccharides and Plant Cell Walls
- Nutrition and Health in Aging
- Biosimilars and Bioanalytical Methods
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- Dementia and Cognitive Impairment Research
- Multiple and Secondary Primary Cancers
- Folate and B Vitamins Research
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- Pregnancy and preeclampsia studies
Second Hospital of Anhui Medical University
2023-2025
Anhui Medical University
2023-2025
Wenzhou Medical University
2025
Fudan University
2017-2024
Guangzhou Medical University
2022-2024
Shanghai Medical College of Fudan University
2020-2024
Third Affiliated Hospital of Guangzhou Medical University
2022-2024
Bristol-Myers Squibb (United States)
2024
Shanghai Polytechnic University
2024
Nankai University
2023
During recent decades China has undergone a rapid transition in the main disease patterns of its population. There been substantial decrease maternal and child mortality adult from themain infectious/parasitic diseases, whereas for ischaemic heart some other non-communicable chronic there moderate increase rates, at least parts China. Consequently, most premature that still remains now involves diseases middle age, such as cancer, stroke, disease, or lung disease. 1–4 In mid-1970s...
Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within receptor binding domain (RBD) spike (S) protein, lead to functional alteration both engagement monoclonal antibody (mAb) recognition. Here, we review data RBD point mutations possessed by major discuss their individual effects on ACE2 affinity immune evasion. Many single amino acid...
Information is the end of big data resource system construction, providing a source fresh water for resources and an important foothold demand. This paper analyzes current situation problems smart campus construction under background informatization. The practical needs development goals are analyzed, four core directions quasi business architecture, application technical architecture explored. In response to shortcomings in information capabilities, ownership, nodes, talents, should be key...
Background Resistance to existing therapies is a major cause of treatment failure in patients with refractory and relapsed B-cell non-Hodgkin’s lymphoma (r/r B-NHL). Therapy-induced senescence (TIS) one the most important mechanisms drug resistance. Methods This study used single-cell RNA sequencing analyze doxorubicin-induced senescent B-NHL cells. C-C chemokine receptor 7 (CCR7) expression aggressive was assessed using immunohistochemistry flow cytometry. Lentiviral transfection target...
Abstract Background Epstein-Barr virus (EBV) is an oncovirus belonging to the herpesvirus family, associated with pathogenesis of multiple malignancies, particularly Burkitt lymphoma (BL). The remains latent in host cells and plays a critical role tumor progression through various mechanisms. A key glycoprotein, gp350, expressed during lytic phase EBV, instrumental viral entry into B presents unique antigenic target, making it promising candidate for immunotherapeutic approaches, such as...
The primary challenges in CD19-specific chimeric antigen receptor T-cell (CD19 CAR T) therapy for patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL) are non-response and relapse; it is urgent to reveal these mechanisms. Neutrophils play a critical role the immunosuppressive tumor microenvironment (TME), which can hinder T efficacy. Our previous research identified subset of neutrophils special phenotype (CD14-CD10-CD45-HLA-DR-SSC++, termed CD10- neuts),...
A schematic diagram showing the IRS1-GLUT4 insulin signaling pathway influenced by PTP1B and FYGL in L6 cells.
The causal relationship between serum ferritin and metabolic syndrome (MetS) remains inconclusive. Dietary iron intake increases ferritin. objective of this study was to evaluate associations total, heme, nonheme dietary with MetS its components in men women metropolitan China. Data from 3099 participants the Shanghai Diet Health Survey (SDHS) obtained during 2012⁻2013 were included analysis. assessed by 24-h diet records 3 consecutive days. Multivariate generalized linear mixed models used...
In the absence of an effective treatment to alter progressive course cognitive decline and dementia, identification modifiable risk factors that could promote healthy aging has become a public health research priority. This study seeks comprehensively determine contemporaneous associations broad spectrum time-varying lifestyle with age-related in large population-based cohort older adults. A total 5711 subjects aged 50 from WHO Study on global AGEing adult (SAGE) Shanghai were studied....
Mitochondrial dysfunction is implicated in the progression of diabetic kidney disease (DKD). Damaged mitochondria produce excessive reactive oxygen species (ROS) that can cause apoptosis. dynamics control quality and function mitochondria. Targeting mitochondrial may reduce ROS-induced apoptosis improve renal injury DKD. Modified Hu-lu-ba-wan (MHLBW) shows distinct clinical effects on DKD patients, which are related to its role antioxidant stress modulation. However, relevant mechanisms...
Background: The associations between dietary cholesterol and fatty acids serum lipids are controversial. This study is to examine the association of with dyslipidemia in Chinese metropolitan male female adults. Methods: 3850 participants Shanghai Diet Health Survey were investigated during period 2012–2013. Information was obtained on intake, anthropometric blood laboratory measurements. Dyslipidemia determined by US National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP...
Striking antibody evasion by emerging circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during evolution is still elusive. Here, we identify clonally related family from convalescent individual. One members, XG005, exhibits potent and broad activities against SARS-CoV-2 variants, while other members show significant reductions in...
The objective of this study was to assess the feasibility and effectiveness a novel WeChat applet-based personalized dietary intervention aimed at promoting healthier intakes. A two-arm parallel, randomized, controlled trial conducted in real-world scenario involved total 153 participants (the group, n = 76; control 77), lasting for 4 months Shanghai, China. group had access visualized nutrition evaluations through applet during workday lunch time, while received no interventions. 3413...
<h3>Objective</h3> CC-97540 (BMS-986353) is an investigational CD19 CAR T-cell therapy utilizing the lisocabtagene maraleucel CD19-directed T construct with a 41BB co-stimulatory domain and epidermal growth factor receptor safety switch manufactured using optimized NEX-T<sup>TM</sup> platform (figure 1A). Here, we present preclinical phase 1 clinical data demonstrating CD19-specific cell targeting, expansion, hypogammaglobulinemia in patients relapsed or refractory non-Hodgkin lymphoma (RR...
Objective This study aimed to investigate clinical features of inhaled nitric oxide (iNO) in preterm infants with a gestational age (GA) < 34 weeks China. Study Design The data 434 GA weeks, treated iNO the neonatology departments eight Class A tertiary hospitals China over 10-year period from January 2013 December 2022, were included this retrospective multicenter investigation. divided into three groups based on GA: 24 27 (extremely infants), 28 31 (very and 32 33 (moderate infants)....
Studies using cross-sectional data or with a short follow-up period fail to distinguish whether the associations between sleep duration and physical activity cognitive function result from reverse causation.