Pamela Linksted
A5058714517- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Health disparities and outcomes
- Genetic Associations and Epidemiology
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Chronic Disease Management Strategies
- Privacy-Preserving Technologies in Data
- Cardiovascular Disease and Adiposity
- Elder Abuse and Neglect
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Aging and Gerontology Research
- Atherosclerosis and Cardiovascular Diseases
- Renal and related cancers
- COVID-19 Clinical Research Studies
- Cardiovascular Health and Risk Factors
- Scientific Computing and Data Management
- Biomedical Text Mining and Ontologies
- COVID-19 and healthcare impacts
- Folate and B Vitamins Research
- Medical Coding and Health Information
- GDF15 and Related Biomarkers
University of Edinburgh
2010-2025
Christchurch Hospital
2022
British Heart Foundation
2022
National Institute for Health Research
2022
University of Otago
2022
London School of Hygiene & Tropical Medicine
2022
Medical Research Council
2022
NHS Lothian
2021
National Health Service
2021
Institute of Genetics and Cancer
2015
Summary GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic clinical data from about 24 000 volunteers across Scotland aged 18–98 years, February 2006 to March 2011. Biological samples anonymized form resource for research on the genetics of health, disease quantitative traits current projected public health importance. Specific important features include recruitment, intent obtaining family groups; breadth depth phenotype information, including detailed...
During recent decades China has undergone a rapid transition in the main disease patterns of its population. There been substantial decrease maternal and child mortality adult from themain infectious/parasitic diseases, whereas for ischaemic heart some other non-communicable chronic there moderate increase rates, at least parts China. Consequently, most premature that still remains now involves diseases middle age, such as cancer, stroke, disease, or lung disease. 1–4 In mid-1970s...
High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine introduction a high-sensitivity I (hs-cTnI) assay with sex-specific 99th centile diagnostic threshold would reduce subsequent infarction or cardiovascular death in patients suspected acute coronary syndrome.In stepped-wedge, cluster-randomised controlled trial across ten secondary tertiary care hospitals...
Background: The introduction of more sensitive cardiac troponin assays has led to increased recognition myocardial injury in acute illnesses other than coronary syndrome. Universal Definition Myocardial Infarction recommends high-sensitivity testing and classification patients with based on pathogenesis, but the clinical implications implementing this guideline are not well understood. Methods: In a stepped-wedge cluster randomized, controlled trial, we implemented assay recommendations 48...
High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the safety and efficacy of this approach is uncertain. We investigated whether an early rule-out pathway safe effective for patients with suspected acute coronary syndrome.
Background Vast sample sizes are often essential in the quest to disentangle complex interplay of genetic, lifestyle, environmental and social factors that determine aetiology progression chronic diseases. The pooling information between studies is therefore central importance contemporary bioscience. However, there many technical, ethico-legal scientific challenges be overcome if an effective, valid, pooled analysis achieved. Perhaps most critically, any data analysed this way must...
The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely contested assumptions. More recently, the MDD large populations from registries such as Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number different relationships provide an alternative means estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS) is (n = 20,198), family-based population study designed to identify genetic...
Major disparities between women and men in the diagnosis, management, outcomes of acute coronary syndrome are well recognized.The aim this study was to evaluate impact implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial infarction suspected syndrome.Consecutive patients were enrolled stepped-wedge, cluster-randomized controlled trial across 10 hospitals. Myocardial injury defined as concentration >99th centile 16 ng/l 34 men. The...
The relevance of blood lipid levels as risk factors for ischemic heart disease (IHD) in older people is uncertain; hence, cholesterol-lowering therapy not routinely prescribed populations.We assessed IHD mortality associations with plasma total cholesterol, low-density lipoprotein high-density apolipoprotein B, and A(1) measured men. Ischemic was a 7-year follow-up cohort 5344 men (mean age, 76.9 years), including 74.3% without cardiovascular (CVD) or statin use 25.6% CVD use. Hazard ratios...
Importance Type 2 myocardial infarction occurs owing to multiple factors associated with oxygen supply-demand imbalance, which may confer different risks of adverse outcomes. Objective To evaluate the prevalence and outcomes imbalance among patients type infarction. Design, Setting, Participants In this secondary analysis a stepped-wedge, cluster randomized clinical trial conducted at 10 tertiary care hospitals in Scotland, 6096 an adjudicated diagnosis 1 or from June 10, 2013, March 3,...
Maternal diabetes in pregnancy affects offspring health. The impact of parental on health is unclear. We investigated the metabolic-health adult-offspring who did not themselves have diabetes. Data from Generation Scotland: Scottish Family Health Study, a population-based family cohort, were record-linked to subjects' own medical records. From F0-parents, we identified F1-offspring of: mothers with (OMD, n = 409), fathers (OFD, 468), no parent (ONoPD, 2489). Metabolic syndrome, body,...
For over a decade, Scotland has implemented and operationalized system of Safe Havens, which provides secure analytics platforms for researchers to access linked, deidentified electronic health records (EHRs) while managing the risk unauthorized reidentification. In this paper, perspective is provided on state-of-the-art Scottish Haven network, including its evolution, define key activities required scale network’s capability facilitate research care improvement initiatives. A set processes...
High-sensitivity cardiac troponin (hs-cTn) assays have improved the diagnosis of myocardial infarction in patients with healthy kidney function and are now widely used clinical practice. 1However, impairment, long-term elevations levels common, interpretation can be more challenging. 2 As such, effect implementing hs-cTn testing on outcomes impairment is uncertain.Methods | High-Sensitivity Troponin Evaluation Patients With Acute Coronary Syndrome (High-STEACS) was a stepped-wedge,...
Abstract Background Sars-CoV-2, the causative agent of COVID-19, has led to more than 226,000 deaths in UK and multiple risk factors for mortality including age, sex deprivation have been identified. This study aimed identify which individual indicators Scottish Index Multiple Deprivation (SIMD), an area-based index, were predictive mortality. Methods was a prospective cohort anonymised electronic health records 710 consecutive patients hospitalised with Covid-19 disease between March June...
<sec> <title>UNSTRUCTURED</title> For over a decade, Scotland has implemented and operationalized system of Safe Havens, which provides secure analytics platforms for researchers to access linked, deidentified electronic health records (EHRs) while managing the risk unauthorized reidentification. In this paper, perspective is provided on state-of-the-art Scottish Haven network, including its evolution, define key activities required scale network’s capability facilitate research care...