Nazir Lone
A5084080194- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Family and Patient Care in Intensive Care Units
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
- Influenza Virus Research Studies
- Hip and Femur Fractures
- Palliative Care and End-of-Life Issues
- Climate Change and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Geriatric Care and Nursing Homes
- Hospital Admissions and Outcomes
- Diabetes and associated disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health disparities and outcomes
University of Edinburgh
2016-2025
Edinburgh Royal Infirmary
2015-2025
NHS Lothian
2021-2025
Queen Elizabeth Hospital
2024
National Health Service
2024
University Hospitals Birmingham NHS Foundation Trust
2024
Asthma UK
2017-2023
Asthma UK Centre for Applied Research
2019-2023
Intensive Care Society
2014-2023
University of Leicester
2023
The impact of COVID-19 on physical and mental health employment after hospitalisation with acute disease is not well understood. aim this study was to determine the effects COVID-19-related employment, identify factors associated recovery, describe recovery phenotypes. Post-hospitalisation (PHOSP-COVID) a multicentre, long-term follow-up adults (aged ≥18 years) discharged from hospital in UK clinical diagnosis COVID-19, involving an assessment between 2 7 months discharge, including detailed...
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge COVID-19, identify factors associated patient-perceived recovery, and potential therapeutic targets by describing the underlying inflammatory profiles of previously described clusters at 5 months discharge.
Rationale: Survivors of critical illness experience significant morbidity, but the impact surviving intensive care unit (ICU) has not been quantified comprehensively at a population level.Objectives: To identify factors associated with increased hospital resource use and to ascertain whether ICU admission was mortality use.Methods: Matched cohort study pre/post-analysis using national linked data registries complete coverage. The consisted patients admitted all adult general ICUs during 2005...
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19) lung fibrosis suggest severe acute respiratory syndrome 2 (SARS-CoV-2) infection may lead to progressive damage. Objectives: The UK Interstitial Lung Disease Consortium (UKILD) post–COVID-19 study interim analysis was planned estimate the prevalence of residual abnormalities in people hospitalized with COVID-19 on basis risk strata. Methods: PHOSP–COVID-19 (Post-Hospitalization COVID-19) used capture...
Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They common debilitating, can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized COVID-19, we identified two distinct biomarker profiles measured during acute admission, which predict outcomes 6 12 months after COVID-19. A first profile links elevated fibrinogen relative...
One in ten severe acute respiratory syndrome coronavirus 2 infections result prolonged symptoms termed long disease (COVID), yet phenotypes and mechanisms are poorly understood
Abstract Introduction The number of patients requiring prolonged mechanical ventilation (PMV) is likely to increase. Transferring specialised weaning units may improve outcomes and reduce costs. aim this study was establish the incidence PMV in a UK administrative health care region without dedicated unit, model potential impact establishing unit. Methods A retrospective cohort undertaken using database admissions three intensive (ICU) from 2002 2006. Using 21 day cut-off define PMV,...
ICU survivors frequently report reduced health-related quality of life, but the relative importance preillness versus acute illness factors in survivor populations is not well understood. We aimed to explore life trajectories over 12 months following discharge, patterns improvement, or deterioration this period, and demographics (age, gender, social deprivation), preexisting health (Functional Comorbidity Index), severity (Acute Physiology Chronic Health Evaluation II score, ventilation...
The objectives of this study were to identify risk factors for severe coronavirus disease 2019 (COVID-19) and lay the basis stratification based on demographic data health records.The design was a matched case-control study. Severe COVID-19 defined as either positive nucleic acid test acute respiratory syndrome 2 (SARS-CoV-2) in national database followed by entry critical care unit or death within 28 days certificate with underlying cause. Up 10 controls per case sex, age, primary practice...
Introduction Very little is known about possible clinical sequelae that may persist after resolution of acute COVID-19. A recent longitudinal cohort from Italy including 143 patients followed up hospitalisation with COVID-19 reported 87% had at least one ongoing symptom 60-day follow-up. Early indications suggest need even more psychological support than typical intensive care unit patients. The assessment risk factors for longer term consequences requires a study linked to data on...
Coronavirus disease 2019 (COVID-19) can lead to significant respiratory failure with between 14% and 18% of hospitalised patients requiring critical care admission. This study describes the impact socioeconomic deprivation on 30-day survival following admission for COVID-19, COVID-19 pandemic capacity in Scotland.This cohort used linked national hospital records including ICU, virology testing death identify describe admitted units Scotland. Multivariable logistic regression was assess...
Background The impact of COVID-19 on physical and mental health, employment following hospitalisation is poorly understood. Methods PHOSP-COVID a multi-centre, UK, observational study adults discharged from hospital with clinical diagnosis involving an assessment between two- seven-months later including detailed symptom, physiological biochemical testing. Multivariable logistic regression was performed for patient-perceived recovery age, sex, ethnicity, body mass index (BMI),...
<h2>Summary</h2><h3>Introduction</h3> The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed evaluate excess burden abnormalities after hospitalisation with COVID-19, their determinants, and explore associations patient-related outcome measures. <h3>Methods</h3> In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included Tier...