Julian A. Hiscox
A5021680442- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Virus-based gene therapy research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- interferon and immune responses
- Viral Infections and Immunology Research
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Plant Virus Research Studies
- COVID-19 epidemiological studies
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Influenza Virus Research Studies
- Space Science and Extraterrestrial Life
- RNA and protein synthesis mechanisms
- Liver Disease and Transplantation
- RNA modifications and cancer
- Vector-Borne Animal Diseases
- RNA regulation and disease
University of Liverpool
2016-2025
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2016-2025
Agency for Science, Technology and Research
2017-2025
Health & Life (Taiwan)
2025
University of Oxford
2021-2023
The Pirbright Institute
1994-2023
University of Bristol
2010-2023
Food and Drug Administration
2023
Agriculture and Forestry University
2023
A*STAR Graduate Academy
2022
Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the earlier SARS-CoV use angiotensin-converting enzyme (ACE2) as a receptor; however, their tissue tropism differs, raising possibility that additional factors are involved. The spike protein of contains cleavage site protease furin is absent from (see Perspective by Kielian). Cantuti-Castelvetri et al. now show...
SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly impacted global human health. We wanted to rapidly characterise the transcriptomic, proteomic and phosphoproteomic landscape of this novel coronavirus provide fundamental description virus's genomic potential.
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase affinity the ACE2 confer antibody escape. In vitro, we show that, although itself is not an evasion mechanism, it increases infectivity associated with enhanced incorporation cleaved into virions. able partially rescue proteins that have acquired Y453F escape...
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved spread West Africa. Miles Carroll colleagues report describe the genetic evolution circulating Africa, based on 2015. Their analysis Africa Sierra Leone, Liberia. is currently witnessing most extensive (EBOV) outbreak so far recorded1,2,3. Until now, there have been 27,013 reported cases 11,134 deaths. The origin thought to a zoonotic...
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases, raising concerns over emergence a strain with increased transmission rate. To understand molecular epidemiology this upsurge, we performed, for first time at epicenter an unfolding outbreak, metagenomic nanopore sequencing directly from patient samples, approach dictated by highly variable genome target pathogen. Genomic data and phylogenetic reconstructions were communicated immediately to authorities World...
In life-threatening coronavirus disease (COVID-19), corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily direct reaction to the presence of severe acute respiratory syndrome 2 (SARS-CoV-2) or an independent immunopathologic process unknown.
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral diseases remain poorly characterized. We analyzed plasma samples 471 hospitalized patients recruited through prospective multicenter ISARIC4C study 39 outpatients with mild disease, enabling extensive characterization of across a full spectrum COVID-19 severity. Progressive elevation levels numerous...
The impact of coronavirus disease (COVID-19) on patients with interstitial lung (ILD) has not been established.
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report dose titration study SARS-CoV-2 in ferret model. After high (5 × 106 pfu) medium 104 virus delivered, intranasally, viral RNA shedding upper respiratory tract (URT) observed 6/6 animals, however, only 1/6 ferrets show similar signs after low 102 challenge. Following sequential culls pathological mild multifocal bronchopneumonia approximately...
Studies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed characterise people disease, assess the level care received, measure in-hospital mortality, examine effect use.We analysed International Severe Acute Respiratory emerging Infection Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK)...
BackgroundCOVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to important short-term long-term consequences for patients, health-care utilisation, system preparedness, society amidst the ongoing COVID-19 pandemic. Our aim was characterise extent effect of complications, particularly in those survive, using International Severe Acute Respiratory Emerging Infections Consortium WHO Clinical Characterisation Protocol...
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand pathogenesis emerging diseases assess safety efficacy vaccines therapeutics. Here, we show that SARS-CoV-2 replicates upper lower respiratory tract causes pulmonary lesions both rhesus cynomolgus macaques. Immune responses against also similar species equivalent those reported milder infections convalescent...
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 which neutralizing single domain antibodies (nanobodies) have significant potential. Their small size and stability mean that nanobodies are compatible with respiratory administration. We report four (C5, H3, C1, F2) engineered homotrimers pmolar affinity the receptor binding (RBD) of spike protein. Crystal structures show C5 H3 overlap...
ABSTRACT COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-2. The B.1.1.529 Omicron variant rapidly emerging and has been designated Variant Concern (VOC). highly transmissible partially or fully evades neutralising antibodies due to high number substitutions the spike glycoprotein. A major question relative severity disease compared previous currently circulating variants To address this, mouse model that recapitulates severe humans, K18-hACE2 mice,...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the respiratory tract but also causes neurological symptoms such as loss of smell and taste, headache, fatigue or severe cerebrovascular complications. Using transgenic mice expressing human angiotensin-converting enzyme (hACE2), we investigated spatiotemporal distribution pathomorphological features in CNS following intranasal infection with SARS-CoV-2 variants, well after prior influenza A virus infection. Apart...
ABSTRACT The subcellular localization of transmissible gastroenteritis virus (TGEV) and mouse hepatitis (MHV) (group I group II coronaviruses, respectively) nucleoproteins (N proteins) were examined by confocal microscopy. proteins shown to localize either the cytoplasm alone or a structure in nucleus. This feature was confirmed be nucleolus using specific antibodies nucleolin, major component nucleolus, microscopy image sections through cell expressing N protein. These findings are...