A5027591757- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Digital Humanities and Scholarship
- Endoplasmic Reticulum Stress and Disease
- COVID-19 epidemiological studies
- Cellular transport and secretion
- Lipid metabolism and biosynthesis
- Disaster Response and Management
- Cancer Diagnosis and Treatment
- Libraries and Information Services
- Mosquito-borne diseases and control
- Attachment and Relationship Dynamics
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Education Methods and Technologies
- Bacillus and Francisella bacterial research
World Health Organization Regional Office for Europe
2022-2024
Philipps University of Marburg
2014-2021
Roche (United States)
2021
Robert Koch Institute
2020-2021
Institute of Virology of the Slovak Academy of Sciences
2021
Saarland University
2019
Universität der Bundeswehr München
2019
Institut für Mikrobiologie der Bundeswehr
2019
Mali-Folkecenter
2019
University at Albany, State University of New York
2011-2018
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved spread West Africa. Miles Carroll colleagues report describe the genetic evolution circulating Africa, based on 2015. Their analysis Africa Sierra Leone, Liberia. is currently witnessing most extensive (EBOV) outbreak so far recorded1,2,3. Until now, there have been 27,013 reported cases 11,134 deaths. The origin thought to a zoonotic...
To end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing cases contacts was required. The ability quickly identify unknown sources chains transmission is key ending EVD epidemic even greater importance context recent reports (EBOV) persistence survivors. Phylogenetic analysis complete EBOV genomes can provide important information on source any infection. A local deep sequencing facility established at...
Tether complexes play important roles in endocytic and exocytic trafficking of lipids proteins. In yeast, the multisubunit transport protein particle (TRAPP) tether regulates endoplasmic reticulum (ER)-to-Golgi intra-Golgi is also implicated autophagy. addition, TRAPP complex acts as a guanine nucleotide exchange factor (GEF) for Ypt1, which homologous to human Rab1a Rab1b. Here, we show that TRAPPC13 other subunits are critically involved survival response several Golgi-disrupting agents....
HER2/neu-positive breast cancer cells have recently been shown to use a unique Warburg-like metabolism for survival and aggressive behavior. These exhibit increased fatty acid synthesis storage compared normal or other tumor cells. Disruption of this synthetic process results in apoptosis. Since the addition physiological doses exogenous palmitate induces cell death cells, pathway is likely operating at its limits these We studied response concentrations identify lipotoxicity-associated...
The secretory pathway is a major determinant of cellular homoeostasis. While research into stress signaling has so far mostly focused on the endoplasmic reticulum (ER), emerging data suggest that Golgi itself serves as an important hub capable initiating responses. To systematically identify novel mediators, we performed transcriptomic analysis cells exposed to three different pharmacological compounds known elicit fragmentation: brefeldin A, golgicide and monensin. Subsequent gene-set...
The H1N1 Eurasian avian-like swine (EAsw) influenza viruses originated from an avian virus. To characterize potential changes in the membrane fusion activity of hemagglutinin (HA) during avian-to-swine adaptation virus, we studied EAsw isolated first years their circulation pigs and closely related contemporary wild aquatic birds. Compared to viruses, were less sensitive neutralization by lysosomotropic agent NH4Cl MDCK cells, had a higher pH optimum hemolytic activity, stable at acidic pH....
Abstract Background The Crabtree-negative yeast species Kluyveromyces lactis has been established as an attractive microbial expression system for recombinant proteins at industrial scale. Its LAC genes allow utilization of the inexpensive sugar lactose a sole source carbon and energy. Lactose efficiently induces LAC4 promoter, which can be used to drive regulated heterologous genes. So far, strain manipulation K. by homologous recombination was hampered high rate non-homologous end-joining....
ABSTRACT Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation HA mammals. We found that introduction avian-virus-like acids at five other positions (positions 62, 81, 92, 144, 193) A/Hong Kong/1/1968 virus decreased viral replication in human cells transmission pigs. Thus, substitutions some these facilitated emergence virus.
COVID-19 transmission and disease dynamics in sub-Saharan Africa are not well understood. Our study aims to provide insight into epidemiology Malawi by estimating SARS-CoV-2 prevalence immunity after infection a hospital-based setting.We conducted hospital-based, convenience sampling, cross-sectional survey for Lilongwe, Malawi. Participants answered questionnaire were tested enzyme-linked immunosorbent assay real-time reverse-transcription polymerase chain reaction (RT-PCR). A surrogate...
The Golgi apparatus is increasingly recognized as a major hub for cellular signaling and involved in numerous pathologies, including neurodegenerative diseases cancer. study of stress-induced pathways relies on the selectivity available tool compounds which currently only few are known. To discover novel Golgi-fragmenting agents, transcriptomic profiles cells treated with brefeldin A, golgicide or monensin were generated compared database gene expression from other bioactive small molecules....
We report detection of Lassa virus and Crimean-Congo hemorrhagic fever infections in the area Bamako, capital Mali. Our investigation found 2 cases infection with each these viruses. These results show potential for both viruses to be endemic
Since the beginning of year 2020, SARS-CoV-2 coronavirus has spread globally at a tremendous pace. Studies on prevalence antibodies in population help estimate number people that have already been infected. They also allow an undetected infections i.e. do not appear data officially reported cases. The interpretation study results needs to consider bias from selective sampling and diagnostic test properties. To promote networking co-operation between scientists, Robert Koch Institute compiled...
Recent work has shown that HER2/neu-positive breast cancer cells rely on a unique Warburg-like metabolism for survival and aggressive behavior. These are dependent fatty acid (FA) synthesis, show markedly increased levels of stored fats disruption the synthetic process results in apoptosis. In this study, we used global metabolite profiling multi-omics network analysis approach to model metabolic changes physiology under palmitate-supplemented growth conditions gain insights into molecular...
The hemagglutinin (HA) of A/H3N2 pandemic influenza viruses (IAVs) 1968 differed from its inferred avian precursor by eight amino acid substitutions. To determine their phenotypic effects, we studied recombinant variants A/Hong Kong/1/1968 virus containing either human-type or avian-type acids in the corresponding positions HA. HA displayed receptor binding profile and high conformational stability typical for duck IAVs. Substitutions Q226L G228S, addition to known effects on specificity...
Adjustment disorder (AD) is one of the most frequent mental health conditions after stressful life experiences in medical setting. The diagnosis has been conceptually redefined International Classification Diseases (ICD-11) and now includes specific symptoms preoccupations failure to adapt. current study assesses prevalence self-reported ICD-11 AD among organ transplantation patients their relatives, explores association patients’ demographic-, transplant-, health-related characteristics...
Lipid droplets (LDs) are ubiquitous intracellular structures whose formation, growth, and maintenance highly regulated (Wang et al., 2013; Ranall 2011; Goodman, 2009). metabolism droplet dynamics of considerable interest to agriculture, biofuel production, viral pathology, nutrition, cancer biology (Walther Farese, 2009; Liu 2010). Accumulation fatty acids neutral lipids in nonadipose tissues is cytotoxic (Kourtidis BODIPY 493/503...
Background/Introduction: Rapid Response Mobile Laboratories (RRML) are a crucial component of preparedness and response to health emergencies, both as stand-alone asset in conjunction with other rapid capacities. The development an RRML classification system 2019 1 defines laboratory structure provides foundation for the minimum standards under umbrella WHO Global Outbreak Alert Network (GOARN). Objectives: These define requirements RRMLs/GOARN field facilitate their interoperability...