Roger Hewson
A5058186910- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Fire effects on ecosystems
- Hepatitis B Virus Studies
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Respiratory viral infections research
- Zoonotic diseases and public health
- Disaster Response and Management
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Malaria Research and Control
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Plant and Fungal Interactions Research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
London School of Hygiene & Tropical Medicine
2014-2025
UK Health Security Agency
2022-2025
University of London
2020-2025
Wellcome Sanger Institute
2025
Public Health England
2015-2024
University of Liverpool
2014-2024
Liverpool School of Tropical Medicine
2018-2023
Nagasaki University
2018-2023
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2014-2022
Oxford Brookes University
2020-2022
Characterizing the Zika virus antibody response Given public health emergency that poses, scientists are seeking to understand Zika-specific immune response. Stettler et al. analyzed 119 monoclonal antibodies isolated from four donors were infected with during present epidemic, including two individuals had previously been dengue virus, another member of flavivirus family. Neutralizing primarily recognized envelope protein domain III (EDIII) or quaternary epitopes on intact and an...
The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel 1), and Singapore 1) became first human cases exported Africa, a related nosocomial transmission event confirmed human-to-human outside of Africa.Epidemiological molecular data for Nigerian were analyzed jointly better understand exportations temporal geographic context outbreak.Isolates all travelers Bayelsa case shared most recent...
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved spread West Africa. Miles Carroll colleagues report describe the genetic evolution circulating Africa, based on 2015. Their analysis Africa Sierra Leone, Liberia. is currently witnessing most extensive (EBOV) outbreak so far recorded1,2,3. Until now, there have been 27,013 reported cases 11,134 deaths. The origin thought to a zoonotic...
Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond Africa and into Pacific South American regions. Despite first being detected in 1947, very little information known about the virus, its been associated with increases Guillain-Barre syndrome microcephaly. There are currently no vaccines or antivirals against ZIKV infection. Progress assessing interventions will require development of animal models to test efficacies; however, there only limited reports on vivo...
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases, raising concerns over emergence a strain with increased transmission rate. To understand molecular epidemiology this upsurge, we performed, for first time at epicenter an unfolding outbreak, metagenomic nanopore sequencing directly from patient samples, approach dictated by highly variable genome target pathogen. Genomic data and phylogenetic reconstructions were communicated immediately to authorities World...
Introduction: Clinical symptoms of malaria and typhoid infections are virtually indistinguishable from those initially seen in many arbovirus infections. Here we describe co-infection detected 310 sera samples collected febrile, clinically suspected malaria/typhoid patients Borno State, Nigeria. Methodology: Tested for Plasmodium falciparum by microscopy Salmonella Typhi Widal test, were subsequently tested chikungunya (CHIKV), yellow fever (YFV), dengue (DENV) West Nile viruses (WNV) plaque...
Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal. There no approved vaccine available, preclinical protection vivo by an experimental has not been demonstrated previously. In present study, attenuated poxvirus vector, Modified Vaccinia virus Ankara, was used to develop recombinant candidate expressing CCHF glycoproteins. Cellular humoral immunogenicity...
Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbreaks in human populations accompanied by significant mortality. Owing the lack of approved therapies, screening programmes potentially efficacious drugs have been undertaken. One these studies has demonstrated possible utility chloroquine against EBOV using pseudotyped assays. In mouse models disease there are conflicting reports therapeutic effects chloroquine. There currently no its efficacy larger and more...
Crimean-Congo hemorrhagic fever (CCHF) is a virulent tick-borne disease with case fatality rate ranging from 10-50% for transmission, and up to 80% nosocomial transmission. Human cases have been reported in over 30 countries across Europe, Asia, Africa. It appears be spreading new areas several reporting their first human of CCHF within the past 10 years. We report novel real-time RT-PCR assay designed amplify conserved region virus S segment. capable detecting strains all 7 groups CCHF,...
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease. The SFTS virus (SFTSV) has been detected in the Haemaphysalis longicornis, which acts as transmission host between animals and humans. SFTSV was first confirmed China 2009 also circulating Japan South Korea. However, it not known if genetic connection exists viruses these regions and, so, how transmitted across China, Korea, Japan. We therefore hypothesize that Korea share common phylogenetic origins samples...
Zika virus RNA has been detected in semen collected several months after onset of symptoms infection. Given the potential for sexual transmission and serious fetal abnormalities resulting from infection during pregnancy, information regarding persistence is critical advancing our understanding risks. We tested serial samples symptomatic male patients United Kingdom who had a diagnosis imported Among initial 23 patients, was at high levels 13 (56.5%) not 9 (39.1%); detection indeterminate 1...
BackgroundThe recent global emergence and re-emergence of arboviruses has caused significant human disease. Common vectors, symptoms geographical distribution make differential diagnosis both important challenging. AimTo investigate the feasibility metagenomic sequencing for recovering whole genome sequences chikungunya dengue viruses from clinical samples.MethodsWe performed using Illumina MiSeq portable Oxford Nanopore MinION on samples which were real-time reverse transcription-PCR...