Yīmíng Bào
A5075882065- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Bioinformatics and Genomic Networks
- Bacteriophages and microbial interactions
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Viral Infections and Outbreaks Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- Microbial Community Ecology and Physiology
- SARS-CoV-2 detection and testing
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Transgenic Plants and Applications
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
Chinese Academy of Sciences
2017-2025
University of Chinese Academy of Sciences
2017-2025
Beijing Institute of Genomics
2017-2025
Nanchang University
2025
Guangxi Medical University
2025
Shanghai Center For Bioinformation Technology
2020-2024
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
Huazhong Agricultural University
2024
Shandong University of Finance and Economics
2023-2024
The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains and curates a publicly available database of annotated genomic, transcript, protein sequence records (http://www.ncbi.nlm.nih.gov/refseq/). leverages data submitted to International Nucleotide Sequence Database Collaboration (INSDC) against combination computation, manual curation, collaboration produce standard set stable, non-redundant reference sequences. augments these sequences with current...
The Genome Sequence Archive (GSA) is a data repository for archiving raw sequence data, which provides storage and sharing services worldwide scientific communities. Considering explosive growth with diverse types, here we present the GSA family by expanding into set of resources archive different purposes, namely, (https://ngdc.cncb.ac.cn/gsa/), Human (GSA-Human, https://ngdc.cncb.ac.cn/gsa-human/), Open Miscellaneous Data (OMIX, https://ngdc.cncb.ac.cn/omix/). Compared 2017 version, has...
Influenza epidemics cause morbidity and mortality worldwide (4). Each year in the United States, more than 200,000 patients are admitted to hospitals because of influenza there approximately 36,000 influenza-related deaths (14). In recent years, several subtypes avian viruses have jumped host species infect humans. The H5N1 subtype, particular, has been reported 328 human cases caused 200 12 countries (World Health Organization,...
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global research in both academia and industry. With explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up updating its core through big archive, curation, integration analysis. In past year, efforts have been made synthesize growing knowledge, particularly single-cell omics precision medicine research, series newly...
Recent technological innovations have ignited an explosion in virus genome sequencing that promises to fundamentally alter our understanding of viral biology and profoundly impact public health policy. Yet, any potential benefits from the billowing cloud next generation sequence data hinge upon well implemented reference resources facilitate identification sequences, aid assembly reads provide annotation sources. The NCBI Viral Genomes Resource is a resource designed bring order this...
Influenza viruses are remarkably adept at surviving in the human population over a long timescale. The influenza A virus continues to thrive even among populations with widespread access vaccines, and be major cause of morbidity mortality. mutates from year year, making existing vaccines ineffective on regular basis, requiring that new strains chosen for vaccine. Less-frequent changes, known as antigenic shift, create against which has little protective immunity, thereby causing worldwide...
The Virus Variation Resource is a value-added viral sequence data resource hosted by the National Center for Biotechnology Information. located at http://www.ncbi.nlm.nih.gov/genome/viruses/variation/ and includes modules seven groups: influenza virus, Dengue West Nile Ebolavirus, MERS coronavirus, Rotavirus A Zika virus. Each module supported pipelines that scan newly released GenBank records, annotate genes proteins parse sample descriptors then map them to controlled vocabulary. These...
Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis 156 complete genomes human H3N2 collected between 1999 2004 from New York State, United States, observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred individual gene segments revealed that reassortment events had occurred among these clades, such one clade present at least since...
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global academic and industrial communities. With explosive accumulation multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands updates core by big archive, integrative analysis value-added curation. In past year, efforts have been devoted integrating multiple omics data, synthesizing growing knowledge, developing new upgrading set...
Epigenome-Wide Association Study (EWAS) has become increasingly significant in identifying the associations between epigenetic variations and different biological traits. In this study, we develop EWAS Atlas (http://bigd.big.ac.cn/ewas), a curated knowledgebase of that provides comprehensive collection knowledge. Unlike extant data-oriented resources, features manual curation knowledge from extensive publications. current implementation, focuses on DNA methylation—one key marks; it...
The National Genomics Data Center (NGDC) provides a suite of database resources to support worldwide research activities in both academia and industry. With the rapid advancements higher-throughput lower-cost sequencing technologies accordingly huge volume multi-omics data generated at exponential scales rates, NGDC is continually expanding, updating enriching its core through big integration value-added curation. In past year, efforts for update have been mainly devoted BioProject,...
An ongoing outbreak of a novel coronavirus infection in Wuhan, China since December 2019 has led to 31,516 infected persons and 638 deaths across 25 countries (till 16:00 on February 7, 2020). The virus causing this pneumonia was then named as the (2019-nCoV) by World Health Organization. To promote data sharing make all relevant information 2019-nCoV publicly available, we construct Novel Coronavirus Resource (2019nCoVR, https://bigd.big.ac.cn/ncov). 2019nCoVR features comprehensive...
Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics pharmacogenomics), at either populational or single-cell levels, can provide a multi-dimensional, integrated profile the heterogeneous process with unprecedented throughput detail. These new strategies allow for exploration...
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), curated knowledgebase that features comprehensive collection systematic curation by multi-omics...
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
The Genome Warehouse (GWH) is a public repository housing genome assembly data for wide range of species and delivering series web services submission, storage, release, sharing. As one the core resources in National Genomics Data Center (NGDC), part China Bioinformation (CNCB; https://ngdc.cncb.ac.cn), GWH accepts both full partial (chloroplast, mitochondrion, plasmid) sequences with different levels, as well an update existing assemblies. For each assembly, collects detailed genome-related...
SARS-CoV-2 is the cause of current global pandemic COVID-19; this virus infects multiple organs, such as lungs and gastrointestinal tract. The microbiome in these including bacteriome virome, responds to infection might also influence disease progression treatment outcome. In a cohort 13 COVID-19 patients Beijing, China, we observed that gut virome were notably different from those five healthy controls. We identified bacterial dysbiosis signature by observing reduced diversity viral shifts...