A5100716228- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
- Influenza Virus Research Studies
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Vector-Borne Animal Diseases
- Metal and Thin Film Mechanics
- Metal Alloys Wear and Properties
- Bacillus and Francisella bacterial research
- Thermal Regulation in Medicine
- Regional Economics and Spatial Analysis
- Cancer Research and Treatments
- Remote Sensing and LiDAR Applications
- Animal health and immunology
- Labor market dynamics and wage inequality
- Environmental Quality and Pollution
- Vaccine Coverage and Hesitancy
Chinese PLA General Hospital
2020-2024
University of International Business and Economics
2024
Beijing Center for Disease Prevention and Control
2021-2023
Inner Mongolia Medical University
2023
Chinese People's Liberation Army
2022
Beijing Forestry University
2022
State Forestry and Grassland Administration
2022
Lanzhou University of Technology
2022
China National GeneBank
2021
BGI Group (China)
2021
SARS-CoV-2 is the cause of current global pandemic COVID-19; this virus infects multiple organs, such as lungs and gastrointestinal tract. The microbiome in these including bacteriome virome, responds to infection might also influence disease progression treatment outcome. In a cohort 13 COVID-19 patients Beijing, China, we observed that gut virome were notably different from those five healthy controls. We identified bacterial dysbiosis signature by observing reduced diversity viral shifts...
Between March and July 1997, a devastating outbreak of foot‐and‐mouth disease (FMD), serotype O, occurred in pigs Taiwan. A total 6147 pig farms with more than 4 million were infected, 37.7 per cent the Taiwan either died (0.18 pigs) or killed (3.85 pigs). The epidemic reached its peak during fifth week after it was first recognised. During eighth ninth weeks, two‐dose blanket vaccination programme instituted which led to large reduction new outbreaks. Except for two cities, whole declared...
Summary Background The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak started at the end of 2019 in Wuhan, China, and spread over 100 countries. SARS-CoV-2 uses membrane protein Angiotensin I converting enzyme 2(ACE2) as a cell entry receptor. Indeed, it was reported that balance Renin-Angiotensin System (RAS), regulated by both ACE ACE2, altered COVID-19 patients. It is controversial, however, whether commonly used anti-hypertensive drugs inhibitor (ACEI) II...
Abstract Background SARS-CoV-2-caused coronavirus disease (COVID-19) is posing a large casualty. The features of COVID-19 patients with and without pneumonia, SARS-CoV-2 transmissibility in asymptomatic carriers, factors predicting progression remain unknown. Methods We collected information on clinical characteristics, exposure history, laboratory examinations all laboratory-confirmed admitted to PLA General Hospital. Cox regression analysis was applied identify prognostic factors. last...
Diagnosis is the key point for confirmation and treatment of COVID-19. we focused on comparative analysis virus dynamics between upper respiratory feces specimens in COVID-19 patients. A total 66 swabs, 51 feces, 56 urine plasma samples were sequentially collected from 23 patients a designated hospital. The all negative, except two severe cases at latest available detection point. Conversely, was shed swabs during diseased period. Ten 12 (83.3%) positive samples, while 14 21 (66.7%) samples....
Abstract The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak began at the end of 2019 in Wuhan, China, and has spread to over 200 countries. In this multicenter retrospective study, we identified 2190 adult patients admitted for laboratory-confirmed COVID-19 three participating centers. Multivariate logistic regression was conducted with comorbid hypertension examine potential association between clinical outcomes, disease severity, characteristics use ACEI,...
Accurate estimation of forest height is crucial for the aboveground biomass and monitoring resources. Remote sensing technology makes it achievable to produce high-resolution maps in large geographical areas. In this study, we produced a 25 m spatial resolution wall-to-wall map Baoding city, north China. We evaluated effects three factors on utilizing four types remote data (Sentinel-1, Sentinel-2, ALOS PALSAR-2, SRTM DEM) with National Forest Resources Continuous Inventory (NFCI) data,...
Abstract The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 elderly 73 young participants 16 months compared safety, immunogenicity, two doses inactivated vaccine BBIBP-CorV by booster dose recombinant protein ZF2001. results showed that vaccination protocol was safe tolerable elderly. After administering BBIBP-CorV, positivity rates titers...
Abstract Background Coronavirus disease 2019 (COVID-19) is pandemic. It critical to identify COVID-19 patients who are most likely develop a severe disease. This study was designed determine the clinical and epidemiological features of associated with development pneumonia factors progression. Methods Seventy consecutive etiologically confirmed admitted PLA General Hospital in Beijing, China from December 27, March 12, 2020 were enrolled this followed-up 16, 2020. Differences laboratory...
Large language models excel at interpreting complex natural instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as "language cellular biology", capturing intricate gene expression patterns level. However, interacting with this "language" through conventional tools is often inefficient and unintuitive, posing challenges for researchers. To address these limitations, we present InstructCell, multi-modal AI...
Abstract Long noncoding RNAs (lncRNAs) are known to be the important regulators in cancer progression. However, role of lncRNA FAM66C (FAM66C) is yet investigated intrahepatic cholangiocarcinoma (ICC). This study aimed investigate effects and related mechanisms ICC. Human ICC tissues cell lines were collected. The expression levels FAM66C, hsa‐miR‐23b‐3p (miR‐23b‐3p), KCND2 detected by qRT‐RCR. transfection experiments employed measure effect on viabilities, migration, invasion cells CCK‐8,...
Abstract Oncolytic viruses (OV) have shown excellent safety and efficacy in preclinical clinical studies. Influenza A virus (IAV) is considered a promising oncolytic virus. In this report, we generated recombinant influenza expressing an immune checkpoint blockade agent targeting CTLA4. Using reverse genetics, virus, termed rFlu‐CTLA4, encoding the heavy chain of CTLA4 antibody on PB1 segment light PA was produced. RFlu‐CTLA4 could replicate to high titers, antibodies were produced allantoic...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the disease 2019 (COVID-19) pandemic, represents a global crisis. Most patients developed mild/moderate symptoms, and status immune system varied in regulatory stages. crosstalk between cells dynamic changes cell contact is rarely described. Here, we analyzed features response paired peripheral blood mononuclear (PBMC) samples from same during Consistent with previous reports, both myeloid T turned...
Objective: To understand the incubation periods of infections Omicron variants BA.2 and BF.7 in two COVID-19 epidemics related factors Beijing provide basic parameters for establishment 2019-nCoV dynamic transmission model. Methods: The cases with specific exposure time onset variant infection epidemic April 2022 October were included analysis. rank-sum test was conducted to estimate differences period between types infections. distribution fitted by using Weibull, Gamma lognormal...
This work aims to research the influence of boron and quenching temperature on microstructures performances boron-bearing high-speed alloy steel. The results showed that hardness wear resistance steel were improved after increasing content. volume fraction boron-rich carbide gradually decreased, increased significantly with rise in temperature. highest comprehensive mechanical properties obtained for samples quenched at 1040 °C. TEM was M7(C, B)3 an HCP structure, precipitated particles...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of disease 2019 (COVID-19). Great international efforts have been put into development prophylactic vaccines and neutralizing antibodies. However, knowledge about B cell immune response induced by SARS-CoV-2 virus is still limited. Here, we report a comprehensive characterization dynamics immunoglobin heavy chain (IGH) repertoire in COVID-19 patients. By using next-generation sequencing technology,...