A5100662644- Monoclonal and Polyclonal Antibodies Research
- Electromagnetic Fields and Biological Effects
- Wound Healing and Treatments
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Toxoplasma gondii Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Traumatic Brain Injury Research
- Histone Deacetylase Inhibitors Research
- Retinal Development and Disorders
- Cell Adhesion Molecules Research
- Retinal and Macular Surgery
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Alzheimer's disease research and treatments
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Redox biology and oxidative stress
- Anesthesia and Neurotoxicity Research
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Connexins and lens biology
- Pulsars and Gravitational Waves Research
Qilu Normal University
2019-2025
Air Force Medical University
2012-2024
Jiaxing University
2024
Xi'an Jiaotong University
2024
Shanxi Medical University
2008-2024
First Hospital of Shanxi Medical University
2024
Capital Medical University
2012-2021
Beijing Children’s Hospital
2021
National Institute for Viral Disease Control and Prevention
2020
The First People’s Hospital of Lianyungang
2020
Abstract Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited cooperativity to develop a therapeutic cocktail against SARS-CoV-2. On basis our previously identified humanized cross-neutralizing H014, systematically analyzed fully human naive library rationally potent neutralizing partner, P17, which confers effective protection in animal model. Cryo-EM studies dissected nature P17...
The on-demand replacement of multifunctional hydrogel wound dressings helps to avoid bacterial colonization, and the painless peeling tissue adhesive hydrogels on site remains a major challenge be solved. In this work, we design develop series dynamic Schiff base network composed cystamine-modified hyaluronic acid, benzaldehyde-functionalized poly(ethylene glycol)-co-poly(glycerol sebacate), polydopamine@polypyrrole nanocomposite (PDA@PPy) with mild removability enhance drug-resistant...
The translationally controlled tumor protein (TCTP) is essential for survival by mechanisms that as yet are incompletely defined. Here we describe an important role of TCTP in response to DNA damage. Upon exposure normal human cells low-dose γ rays, the level was greatly increased, with a significant enrichment nuclei. up-regulation occurred manner dependent on ataxia-telangiectasia mutated (ATM) kinase and DNA-dependent associated protective effects against In chromatin irradiated cells,...
Anterior chamber depth (ACD) is becoming a hot topic and plays an important role in correcting the refractive errors (REs) after cataract surgery. The aim of this study was to assess ACD changes their relationship with REs phacoemulsification intraocular lens (IOL) implantation patients age-related cataracts. One hundred forty-five eyes 125 from Department Ophthalmology, Tangdu Hospital, China, were recruited. IOL Master used for axial length (AL) power calculation measurements, Pentacam HR...
Ion-conducting hydrogels with excellent flexibility and ductility have great potential in human movements monitoring. However, some obstacles, including a small detection range, low sensitivity, electrical conductivity, poor stability under extreme conditions, impede their use as sensors. Herein, an ion-conducting hydrogel comprising acrylamide (AM), lauryl methacrylate (LMA), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), water/glycerol binary solvent (named the AM-LMA-AMPS-LiCl...
Increasing evidence indicates that various cancer cell types are capable of producing IgG. The exact function cancer-derived IgG has, however, not been elucidated. Here we demonstrated the expression genes with V(D)J recombination in 80 cases colorectal cancers, 4 colon lines and a tumor bearing immune deficient mouse model. was associated differentiation, pTNM stage, lymph node involvement inflammatory infiltration positively correlated expressions Cyclin D1, NF-κB PCNA. Furthermore,...
Wound healing remains a challenge worldwide, and an ideal wound dressing that promotes is urgently needed. In this study, we developed thermosensitive injectable hydrogel known as the decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network (t-DPI) based on tissue (DAT) temperature-controlled platelet-rich (t-PRP). Abundant platelets, growth factors (GFs), bioactive substances from extracellular matrix (dECM) in t-DPI had positive effects healing. The morphology,...
Purpose.: To study the effect of age on morphologic and biochemical alterations induced by in vivo exposure ultraviolet radiation (UV). Methods.: Young old C57BL/6 mice were exposed to broadband UVB+UVA euthanized after 2 days. Another batch UV-exposed young was monitored for changes 1, 2, 4, 8 Age-matched nonexposed served as controls. Lens documented slit-lamp biomicroscopy dark field microscopy photographs ex vivo. homogenates analyzed glutathione (GSH) level, activities thioredoxin...
<title>Abstract</title> The origin of fast radio bursts (FRBs), the brightest cosmic explosions, is still unknown<sup>1–3</sup> . Bearing critical clues to FRBs’ origin, long-term evolution FRBs has yet be con- firmed, since field young and most were seen only once. Here we report clear evidence decadal FRB 20121102A, first precisely localized repeater. In conjunction with archival data, our FAST GBT monitoring campaign 2020 reveals a significant ∼7% decline local dispersion measure (DM)....
The aim of this study was to investigate the spectrum thalassemia mutations in Yunnan Province, Southwestern China. We detected 450 patients and carriers by multiplex gap polymerase chain reaction (gap-PCR), PCR reverse dot-blot hybridization direct sequencing methods 535 suspected patients. Four types α-thalassemia (α-thal) mutations, – –SEA (59.2%), –α3.7 (rightward) (19.0%), Hb Constant Spring [Hb CS, α142, Term→Gln, TAA>CAA (α2), αCSα] (15.5%), –α4.2 (leftward) (6.34%) were detected. Six...
Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety malignant tumors. However, the impact TCTP glioma remains unclear. The objective this study was to investigate expression and prognostic value patients. Western blot analysis used characterize patterns 45 22 normal brain tissues. Immunohistochemistry on tissue microarray containing 127 cases performed analyze association between clinicopathological features. Compared with tissues, significantly...
This article deals with the utterance-level modalities missing problem uncertain patterns on emotion recognition in conversation (ERC) task. Present models generally predict speaker's emotions by its current utterance and context, which is degraded modality considerably. Our work proposes a framework missing-modality robust (M2R2), trains model iterative data augmentation learned common representation. First, network called party attentive (PANet) designed to classify emotions, tracks all...
Male Sprague Dawley rats were exposed to EMP irradiation of 100 kV/m peak-to-peak e-field intensity and different numbers pulses. Rat sperm samples prepared for analysis qualities; Testes assessed by transmission electron microscopy serum hormone concentrations examined radioimmunoassay; Enzymatic activities Total-superoxide dismutase(T-SOD) manganese-superoxide dismutase (MnSOD), the mRNA levels MnSOD cuprozinc-superoxide (CuZnSOD), density malondialdehyde (MDA) also determined. did not...
The purpose of this study was to determine if race/ethnicity may influence performance college students on the Behavioral Assessment Dysexecutive Syndrome (BADS) and Wisconsin Card Sorting Test (WCST), two different tests executive function (EF). A total 149 participants who self-identified as African American (AA), European (EA), Latina/o (LA) constituted three racial/ethnic groups. Participants ranged in age range from 18 24 years old (SD = 1.29) none reported histories disabilities. BADS...