A5084357635- Mechanisms of cancer metastasis
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Trace Elements in Health
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Infrared Target Detection Methodologies
- Magnesium in Health and Disease
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Advanced SAR Imaging Techniques
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- Remote-Sensing Image Classification
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Cancer-related molecular mechanisms research
Zunyi Medical University
2025
Civil Aviation University of China
2018-2024
The First Hospital of Changsha
2023-2024
Air Force Medical University
2013-2023
Xijing Hospital
2005-2023
Tsinghua University
2023
Naval Aeronautical and Astronautical University
2013-2022
National Aviation University
2021
Hunan Provincial People's Hospital
2021
Soochow University
2021
Bruton tyrosine kinase (EC 2.7.1.112) [Btk, encoded by Btk in mice and BTK humans (formerly known as atk, BPK, or emb)], which is variously mutated chromosome X-linked agammaglobulinemia patients immunodeficient (xid) mice, has the pleckstrin homology (PH) domain at its amino terminus. The PH of expressed a bacterial fusion protein directly interacts with C mast cell lysates. Evidence was obtained that physically associated intact murine cells well. Both Ca(2+)-dependent (alpha, beta I, II)...
We investigated the role of Bruton's tyrosine kinase (Btk) in FcεRI-dependent activation mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, development is apparently normal these However, cells derived from mice exhibited significant abnormalities function. primed with anti-dinitrophenyl monoclonal IgE antibody mildly diminished early-phase severely blunted late-phase anaphylactic reactions response to antigen challenge vivo. Consistent this finding, cultured...
Tyrosine phosphorylation of several cellular proteins is one the earliest signaling events induced by cross-linking high-affinity receptor for immunoglobulin E (Fc epsilon RI) on mast cells or basophils. kinases activated during this process include Src family kinases, Lyn, c-Yes, and c-Src, members another subfamily, Syk PTK72 (identical highly related to Syk). Recently, some us described two novel tyrosine Emb Emt, whose expression was limited subsets hematopoietic cells, including cells....
The most severe form of brain glioma, glioblastoma (GBM), is highly malignant and usually resistant to chemotherapy. Therefore, discovery new targets for gene therapy important. Using subtraction cloning, we identified the human N-Myc downstream-regulated 2 (hNDRG2), located at chromosome 14q11.2, as a that significantly suppressed in GBM tissues. Semiquantitative RT-PCR showed hNDRG2 transcript expressed normal tissue low-grade gliomas but present low levels 15 27 (56%) tissues all 6 cell...
The MYC oncogene is overexpressed in hepatocellular carcinoma (HCC) and has been associated with widespread microRNA (miRNA) repression; however, the underlying mechanisms are largely unknown. Here, we report that c-Myc oncogenic transcription factor physically interacts enhancer of zeste homolog 2 (EZH2), a core enzymatic unit polycomb repressive complex (PRC2). Furthermore, miR-101, an important tumor-suppressive miRNA human hepatocarcinomas, epigenetically repressed by PRC2 c-Myc-mediated...
The POU transcription factor OCT4 is a pleiotropic regulator of gene expression in embryonic stem cells. Recent studies demonstrated that aberrantly expressed multiple types human cancer; however, the underlying molecular mechanism remains largely unknown. In this study, we report OCT4-pg4, pseudogene OCT4, abnormally activated hepatocellular carcinoma (HCC). level OCT4-pg4 positively correlated with and both transcripts can be directly targeted by tumor-suppressive micro RNA miR-145. We...
Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions worldwide for its anti-tumor efficacy. Celastrol Triptolide, two active components extracted from the herb Tripterygium wilfordii Hook F (known as Lei Gong Teng or Thunder of God Vine), shown effects. was identified a natural 26 s proteasome inhibitor which promotes cell apoptosis inhibits tumor growth. The effect mechanism Triptolide on prostate cancer (PCa) is not well studied. Here we demonstrated...
Transforming growth factor-β (TGF-β) has received much attention as a major inducer of epithelial-mesenchymal transition (EMT) during cancer progression, mainly by activating set pleiotropic transcription factors including SNAI2/Slug.However, the involvement long non-coding RNAs (lncRNAs) in TGF-β-induced Slug activation and EMT remains largely unknown.Methods: In this study, we used microarray analysis to compare lncRNA expression profiles between TGF-β treated untreated breast cells.Then,...
Mast cells derived from Bruton's tyrosine kinase (Btk)-defective xid or btk null mice showed greater expansion in culture containing interleukin-3 (IL-3) than those wild-type (wt) mice. Although the proliferative response to IL-3 was not significantly different between wt and mast cells, died by apoptosis more slowly their counterparts upon deprivation. Consistent with these findings, apoptosis-linked c-Jun N-terminal kinase/stress-activated protein (JNK) activity compromised btk-mutated...
In adults, angiogenic abnormalities are involved in not only tumor growth but several human inherited diseases as well. It is unclear, however, concerning how the normal vascular structure maintained and angiogenesis initiated adults. Using Cre-LoxP-mediated conditional gene deletion, we show present study that adult mice disruption of transcription factor recombination signal-binding protein Jkappa (RBP-J) endothelial cells strikingly induced spontaneous multiple tissues, including retina...
Abstract Discoidin domain receptor 2 (DDR2) belongs to tyrosine kinase (RTK) family and is activated by collagen binding. Although the bone defects in Ddr2 null mice have been reported for a decade, molecular mechanism remains unclear. This study sought investigate function detailed of DDR2 osteogenic chondrogenic differentiation. Herein we found that preosteoblastic cells, activation was enhanced induction but not paralleled with alteration expression. Under differentiated condition,...
The NDRG2 gene belongs to a family of N-Myc downstream-regulated genes (NDRGs) and is expressed in many normal tissues. expression has been shown be regulated the stress response certain cells. However, its function not yet fully understood. Many studies have demonstrated that hypoxia, one responses, induced apoptosis several cell types. In current study, we investigated involvement hypoxia found was markedly up-regulated tumor lines exposed hypoxic conditions or similar stresses at mRNA...
Abstract Background The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate disease. Understanding molecular mechanisms underlying HCC metastasis extremely urgent. role CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC. Methods mRNA protein expression was analyzed MHCC97H, Huh7 L-02 cells. Changes cell adhesion, migration invasion were detected by up- or down-regulating...
// Xinyuan Xu 1, * , Jianying Li Xiang Sun 2, Yan Guo Dake Chu 3 Wei 4 Xia 1 Guodong Yang Xinping Liu Libo Yao Jian Zhang Lan Shen The State Key Laboratory of Cancer Biology, Department Biochemistry and Molecular Fourth Military Medical University, Xi'an, Shaanxi, China 2 Prosthodontics, School Stomatology, Gastrointestinal Surgery, Xijing Hospital Digestive Diseases, Obstetrics Gynecology, Hospital, These authors have contributed equally to this work Correspondence to: Zhang, e-mail:...