A5101509607- Natural Compounds in Disease Treatment
- Sleep and Wakefulness Research
- Sleep and related disorders
- Reproductive Biology and Fertility
- Animal Genetics and Reproduction
- Cell death mechanisms and regulation
- Traditional Chinese Medicine Studies
- Ubiquitin and proteasome pathways
- Cervical Cancer and HPV Research
- Histone Deacetylase Inhibitors Research
- AI in cancer detection
- Calcium signaling and nucleotide metabolism
- Plant Disease Resistance and Genetics
- DNA Repair Mechanisms
- Molecular Biology Techniques and Applications
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Cancer Mechanisms and Therapy
- Aquaculture Nutrition and Growth
- Breast Cancer Treatment Studies
- Hedgehog Signaling Pathway Studies
- Cholinesterase and Neurodegenerative Diseases
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Cardiac electrophysiology and arrhythmias
Fujian Provincial Cancer Hospital
2018-2025
Shanghai Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Inner Mongolia Medical University
2020
Third Affiliated Hospital of Inner Mongolia Medical College
2020
Henan Agricultural University
2018
Shandong Provincial QianFoShan Hospital
2015-2017
Shandong University
2015-2017
Northwest A&F University
2012-2017
Peking Union Medical College Hospital
2014
Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions worldwide for its anti-tumor efficacy. Celastrol Triptolide, two active components extracted from the herb Tripterygium wilfordii Hook F (known as Lei Gong Teng or Thunder of God Vine), shown effects. was identified a natural 26 s proteasome inhibitor which promotes cell apoptosis inhibits tumor growth. The effect mechanism Triptolide on prostate cancer (PCa) is not well studied. Here we demonstrated...
Enzalutamide is a second-generation androgen receptor (AR) antagonist for the treatment of metastatic castration-resistant prostate cancer (mCRPC).Unfortunately, AR dysfunction means that resistance to enzalutamide will eventually develop.Thus, novel agents are urgently needed treat this devastating disease.Triptolide (TPL), key active compound extracted from Chinese herb Thunder God Vine (Tripterygium wilfordii Hook F.), possesses anti-cancer activity in human cells.However, effects TPL...
The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it unknown whether its therapeutic effect relates with PCa. Here we described as cells. Our data showed that suppressed cell growth reduced the expression EZH2. Overexpression attenuated induced inhibition. Moreover, treatment PC-3 cells resulted elevated mRNA levels genes (ADRB2,...
<sec> <title>BACKGROUND</title> Selecting patients who benefit from neoadjuvant chemotherapy (NAC) in breast cancer remains a challenge. </sec> <title>OBJECTIVE</title> This study evaluated multiomic integration with stacked-ensemble machine learning to predict NAC response and recurrence risk. <title>METHODS</title> We retrospectively analyzed 124 treated (3–8 cycles) before mastectomy. Two radiomics signatures were developed: RadSET (entire tumor) RadSITH (intratumoral heterogeneity)...
1117 Background: Trastuzumab deruxtecan (T-DXd) has been approved for patients (pts) with HER2-ultralow metastatic breast cancer (MBC). HER2 discordance commonly occurs between primary and lesions within the same patient; however, its incidence remains unknown in era. Additionally, there is still controversy about which specimen to use determine status optimal threshold guide T-DXd therapy. Methods: This national, multicenter cohort study included MBC pts treated (5.4 mg/kg) available both...
Triptolide, an active compound extracted from Chinese herb Leigongteng (Tripterygium wilfordii Hook F.), shows a broad-spectrum of anticancer activity through its cytotoxicity. However, the efficacy triptolide on laryngocarcinoma rarely been evaluated, and mechanism by which triptolide-induced cellular apoptosis is still not well understood. In this study, we found that significantly inhibited HEp-2 cells proliferation, migration survivability. Triptolide induces cell cycle arrest at G1...
Obstructive sleep apnea is a highly prevalent but under-recognized disorder that causes neurocognitive deficits such as spatial memory and learning deficits. These are frequently accompanied by an increase in orexin-A, which has been shown to be involved well neuronal apoptosis brain areas cognition, the hippocampus. The aim of this work was study possible harmful effects orexin-A on intermittent hypoxemia-induced hippocampal damage investigate potential underlying molecular mechanisms...
Due to lack of systematic reviews, BRCA, DNA Repair Associated (BRCA) mutations in the Chinese population are not completely understood. The following study investigates prevalence and type BRCA patients with high hereditary risk breast cancer (BC). Patients Drwere recruited from 14 cities between October 2015 February 2016, were selected based on family personal medical history. analyzed by collecting blood samples all participants. 437 BC included. A total seventy-six (17.4%) mutation...
This study aimed to evaluate the impacts of wild and breeding juvenile rice field eel under conditions ammonia heat stress. The growth performance (FBW, WGR, SGR, FCR) 360 (24.22 ± 0.30 g) (24.16 0.27 strains was significantly hindered by inhibitory effects were more obvious when two stresses combined. survival rates outperformed that identical stress conditions, this explained expression growth-related gene ( gh ). They have increased enzyme activity (CAT GSH-Px) immune-related genes cat ,...
Objective To investigate the correlation between spatial memory and sleep architecture hippocampal volumes in patients with chronic insomnia disorder. Methods Twenty-two 17 normal sleepers (controls) were selected to evaluate subjective using Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Insomnia Severity (ISI) objective by polysomnography (PSG). The cognitive function was measured Montreal Cognitive Assessment (MoCA). Spatial object-memory Nine-box Maze,...
Xylanase can hydrolyze xylan for reducing its anti-nutritional impact and improving nutrient availability, so obtaining suitable xylanase to degrade is essential.Error-prone PCR gene transformation were used in this study obtain the ideal degrading effectively.The result showed that one mutant with high expression was obtained.After connected pGAPZαA transformed into Pichia pastoris (P.pastoris), recombinant P. found produce higher activity (0.1480 U/mL) than native (0.1360 after 12 h...
Objective To investigate the effect of leptin on quality and function sperm after freezing thawing by adding to human cryoprotective solution. Methods Semen samples were collected at Reproductive Medicine Center Third Affiliated Hospital Inner Mongolia Medical University from January December 2017. Samples with a progressive ratio≥32% concentration ≥15×106/ml included in normal group, while those ratio<32% <15×106/ml an asthenozoospermia (AS) group. The liquefied semen mixed...