A5100614354- Immune cells in cancer
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Natural Compounds in Disease Treatment
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Tryptophan and brain disorders
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Molecular Junctions and Nanostructures
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
Chongqing Medical University
2020-2024
Children's Hospital of Chongqing Medical University
2021-2024
University of Alberta
2017-2022
Northwest A&F University
2012
Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity still unclear. Here, we studied effect breast cancer and its possible molecular mechanism.The changes macrophage phenotypes after treatment were detected by western blot, quantitative polymerase chain reaction (PCR) flow cytometry. Western blot was used to study signal mechanism regulating this process. The number localization immune cells Wild-type (WT) PGRN-/-...
Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions worldwide for its anti-tumor efficacy. Celastrol Triptolide, two active components extracted from the herb Tripterygium wilfordii Hook F (known as Lei Gong Teng or Thunder of God Vine), shown effects. was identified a natural 26 s proteasome inhibitor which promotes cell apoptosis inhibits tumor growth. The effect mechanism Triptolide on prostate cancer (PCa) is not well studied. Here we demonstrated...
Triple negative breast cancer (TNBC) is a subtype of with poor prognosis and high mortality rate. The tumor suppressor phosphatase tensin homolog deleted on chromosome 10 (PTEN) plays an important role in cell proliferation migration by negatively regulating the PI3K/Akt pathway. PTEN downregulated microRNAs multiple cancers. However, few have been reported to directly target TNBC. In this study, predicted were screened immunoblotting luciferase reporter assays. Expression levels...
The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it unknown whether its therapeutic effect relates with PCa. Here we described as cells. Our data showed that suppressed cell growth reduced the expression EZH2. Overexpression attenuated induced inhibition. Moreover, treatment PC-3 cells resulted elevated mRNA levels genes (ADRB2,...
Chemotherapy, as one of the principal modalities for cancer therapy, is limited by its non-specific and inefficient delivery to tumors. To overcome these limitations, we report herein a dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) achieve efficient, stable, targeted drugs. Firstly, was formed rolling circle amplification. By reasonable design, double target multivalent aptamers were decorated on load DOX. The results confirmed that DTA-H can deliver chemotherapy drugs aptamer...
Abstract Background Tumor microenvironment actually reduces antitumor effect against the immune attack by exclusion of CD8 + T cells. Progranulin (PGRN) is a multifunctional growth factor with significant pathological effects in multiple tumors; however, its role immunity evasion breast cancer (BCa) not completely understood. Methods We depleted GRN (PGRN gene) genetically mice or specifically PY8119 murine BCa cell line, and mouse models orthotopic subcutaneous transplantation were used....
Abstract Background: Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity still unclear. Here, we studied effect breast cancer and its possible molecular mechanism. Methods: The changes macrophage phenotypes after treatment were detected by western blot, quantitative PCR flow cytometry. Western blot was used to study signal mechanism regulating this process. number localization immune cells WT -/- tissues analyzed...
Abstract There is increasing interest in depleting or repolarizing tumor-associated macrophages (TAMs) to generate a pro-inflammatory effect. However, TAMs usually display an immunosuppressive M2-like phenotype tumor microenvironment. Apparently, developing macrophage targeting delivery system with immunomodulatory agents urgent. In the study, efficient siRNAs and CpG ODNs (CpG-siRNA-tFNA) was prepared nucleic acid stepwise self-assembled. The tFNA composed of showed higher stability...