A5045264166- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- interferon and immune responses
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Fungal and yeast genetics research
- RNA modifications and cancer
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- PI3K/AKT/mTOR signaling in cancer
- Hedgehog Signaling Pathway Studies
- Cancer Mechanisms and Therapy
- DNA Repair Mechanisms
- Criminal Law and Evidence
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Evaluation and Performance Assessment
- dental development and anomalies
- Oral and Maxillofacial Pathology
- Genomics and Chromatin Dynamics
University of Alberta
2016-2025
Stollery Children's Hospital
2025
Chengdu University of Traditional Chinese Medicine
2024
Heritage Medical Research Clinic
2013-2021
Faculty (United Kingdom)
2013
Alberta Hospital Edmonton
2012
University of Alberta Hospital
2012
The University of Texas MD Anderson Cancer Center
2011
University of Aberdeen
1998-2007
University of Toronto
2003-2005
The ALS ( a gglutinin- l ike s equence) gene family of Candida albicans encodes eight cell-surface glycoproteins, some which are involved in adherence to host surfaces. A mutational analysis each is currently being performed deduce the functions encoded proteins and better understand role these C. biology pathogenesis. This paper describes construction an als3 / mutant comparison its phenotype als1 strain. Efforts disrupt ALS3 indicated that could be deleted two transformation steps,...
ABSTRACT Candida albicans expresses specific virulence traits that promote disease establishment and progression. These include morphological transitions between yeast hyphal growth forms are thought to contribute dissemination invasion cell surface adhesins attachment the host. Here, we describe regulation of adhesin gene ALS3 , which is expressed specifically during development in C. . Using a combination reporter constructs regulatory mutants, show this mediated by multiple factors at...
Triple negative breast cancer (TNBC) is a subtype of with poor prognosis and high mortality rate. The tumor suppressor phosphatase tensin homolog deleted on chromosome 10 (PTEN) plays an important role in cell proliferation migration by negatively regulating the PI3K/Akt pathway. PTEN downregulated microRNAs multiple cancers. However, few have been reported to directly target TNBC. In this study, predicted were screened immunoblotting luciferase reporter assays. Expression levels...
Osteosarcoma affects both adolescents and adults, some improvement in the survival rate for affected patients has been reached last decade.Still, non-specificity systemic toxicity may limit traditional therapeutic approaches to extent.The insulin growth factor 1 (IGF1) its binding protein (IGFBP3) have implicated tumorigenesis.Nanoparticles, such as graphene oxide (GO), can provide an effective treatment cancer they specifically target cells while reducing undesired side effects.This study...
MicroRNAs (miRNAs) are small RNA molecules that regulate more than 30% of genes in humans. Recent studies have revealed miRNAs play a crucial role tumorigenesis. Large sets human tumors under-expressed compared to normal tissues. Furthermore, experiments shown interference with miRNA processing enhances Multiple documented the causal cancer, and miRNA-based anticancer therapies currently being developed. This review primarily focuses on two key points: (1) their cancer (2) regulation tumor...
ABSTRACT Efg1 is essential for hyphal development in the human pathogen Candida albicans under most conditions. related to basic helix-loop-helix regulators, and therefore workers presume that a transcription factor. Here we confirm DNA binding protein can interact specifically with E box.
Criminal justice in England and Wales constructing the suspect population police station building case - interrogation records non-interrogation evidence grading sorting reviewing for prosecution acquittals convictions understanding criminal process problems of law reform.
// Hong Wu 1 , Roger P. Leng Department of Laboratory Medicine and Pathology, University Alberta, Edmonton, Canada Correspondence to: Wu, e-mail: hwu8@ualberta.ca Leng, rleng@ualberta.ca Keywords: ubiquitin E3 ligase, ubiquitination, tumor suppressor, oncogene, protein degradation Received: March 11, 2015 Accepted: May 14, Published: 26, 2015 ABSTRACT The p73, a homologue the suppressor p53, is capable inducing apoptosis cell cycle arrest. MDM2 transcriptionally...
The major clinical problem in human cancer is metastasis. Metastases are the cause of 90% deaths. TAp63 a critical suppressor tumorigenesis and ΔNp63 acts as dominant-negative inhibitor to block function p53 TAp63. Although several ubiquitin E3 ligases have been reported regulate p63 stability, mechanism regulation remains partially understood. Herein, we show that CHIP, an ligase with U-box domain, physically interacts promotes degradation. Notably, Hsp70 depletion by siRNA stabilizes H1299...
p73, a homolog of the tumor suppressor p53, transactivates many p53 target genes, leading to apoptosis or cell-cycle arrest. p73 has recently been reported play an important role in suppression mouse model. Here, we show that Pirh2 physically interacted with and downregulated function through its E3 ligase activity. promoted ubiquitination vivo vitro. Intriguingly, primarily used K63-linked chains ubiquitinate vitro, but vivo, utilized K11-, K29-, K48-, promote ubiquitination. Depletion by...
Phosphorylation of p53 is a key mechanism responsible for the activation its tumor suppressor functions in response to various stresses. In unstressed cells, rapidly turned over and maintained at low basal level. After DNA damage or other forms cellular stress, level increases, protein becomes metabolically stable. However, phosphorylated regulation unclear. this study, we studied kinetics UBE4B, Hdm2, Pirh2, Cop1 CHIP induction activation. We show that UBE4B coimmunoprecipitates with...
Genomic imprinting plays an important role in the growth and development of mammals. When original imprint status these genes is lost, known as loss (LOI), it may affect growth, neurocognitive development, metabolism, even tumor susceptibility. The LOI has gradually been found not only early event tumorigenesis, but also to be involved progression. More than 120 imprinted had identified humans. In this review, we summarized most studied two gene clusters 13 single cancers. We focused on...
The p53 tumor suppressor protein plays a crucial role in detecting and eliminating various oncogenic threats by promoting processes such as cell cycle arrest, DNA repair, senescence, apoptosis. UBE4B is essential for negatively regulating during normal conditions following damage. In previous studies, we demonstrated that targets phosphorylated degradation response to However, the regulation of relation damage cancer not well understood. this study, show regulated through phosphorylation...
Rad6p plays important roles in post‐replication DNA repair, chromatin organization, gene silencing and meiosis. In this study, we show that also regulates yeast‐hypha morphogenesis the human pathogen Candida albicans . CaRAD6 cDNAs were isolated characterized revealing carries two 5′‐proximal introns. CaRad6p shows a high degree of sequence similarity to Rad6 proteins from fungi man (60–83% identity), it suppresses UV sensitivity lack induced mutagenesis displayed by Saccharomyces cerevisiae...