A5081964627- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- RNA Research and Splicing
- Pharmaceutical and Antibiotic Environmental Impacts
- Genomic variations and chromosomal abnormalities
- Pesticide and Herbicide Environmental Studies
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Music Therapy and Health
- Identity, Memory, and Therapy
- Pesticide Residue Analysis and Safety
- Insect and Pesticide Research
- Diverse Music Education Insights
- Neuroscience and Music Perception
- Cancer-related gene regulation
- Genomics and Rare Diseases
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Animal Disease Management and Epidemiology
- Phagocytosis and Immune Regulation
University of Alberta
2016-2025
Stollery Children's Hospital
2020-2025
Tongji Hospital
2025
Huazhong University of Science and Technology
2025
Air Force Medical University
2023-2024
Xijing Hospital
2023-2024
Zhejiang University
2021-2024
University of Baltimore
2022-2024
Johns Hopkins University
2022-2024
Johns Hopkins Medicine
2022-2024
N6-methyladenosine (m6A) in mRNA is the most abundant and reversible modification. However, mechanism behind decrease m6A patients with type 2 diabetes (T2D) has not yet been thoroughly investigated. To clarify whether glucose involved dynamic regulation of T2D to identify a possible underlying mechanism. Liquid chromatography/electrospray ionization/tandem mass spectrometry quantitative PCR were performed determine content expression target genes 102 107 controls. An additional 12 normal...
Recent reports indicate that copy number variations (CNVs) within the human genome contribute to nucleotide diversity a larger extent than single polymorphisms (SNPs). In addition, contribution of CNVs disease susceptibility may be greater previously expected, although complete understanding phenotypic consequences is incomplete. We have recently reported comprehensive view among 270 HapMap samples using high-density SNP genotyping arrays and BAC array CGH. this report, we describe novel...
N(6)-methyladenosine (m(6)A) modification plays a fundamental role in the epigenetic regulation of mammalian transcriptome. m(6)A can be demethylated by fat mass- and obesity-associated (FTO) protein α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) protein. However, importance alteration type 2 diabetes mellitus (T2DM) has not been explored.The objective study was to investigate whether content reduced T2DM patients correlated with mRNA expression levels FTO ALKBH5 genes.In this...
5-Methylcytosine (5-mC) is an important epigenetic modification involved in development and frequently altered cancer. 5-mC can be enzymatically converted to 5-hydroxymethylcytosine (5-hmC). 5-hmC modifications are known prevalent DNA of embryonic stem cells neurons, but the distribution human liver tumor matched control tissues has not been rigorously explored.We developed online trapping/capillary hydrophilic-interaction liquid chromatography (cHILIC)/in-source fragmentation/tandem mass...
Abstract Male infertility is a worldwide medical problem. Asthenozoospermia common cause of infertility. Epigenetic modifications DNA and histones have been shown to influence human infertility, but no research has explored whether N 6 -methyladenosine (m A) level in RNA associated with asthenozoospermia. Here, we collected total 52 semen samples, including 20 asthenozoospermia patients 32 healthy controls. An LC-ESI-MS/MS method was used detect m A contents sperm RNA, real-time PCR...
Aging is a substantial risk factor for the development of osteoarthritis (OA) and, probably, an essential substrate neoplastic disease bone, such as osteosarcoma, which most common malignant mesenchymal primary bone tumor. Genetic studies have established that insulin/insulin-like growth 1 (IGF-1)/phosphatidylinositol-3 kinase (PI3K)/AKT (Protein Kinase B) signal transduction pathway involved across species, including nematodes, fruit flies, and mammals. SIRT1, phylogenetically-conserved...
Abstract BACKGROUND Hepatocellular carcinoma (HCC) is strongly associated with hepatitis B virus (HBV) infection. False-negative results are common in routine serological tests and quantitative real-time PCR because of HBV surface antigen (HBsAg) variation low copy number. Droplet digital (ddPCR), a next generation PCR, novel, sensitive, specific platform that can be used to improve detection. METHODS A total 131 HCC cases different tumor stages clinical features were initially classified...
Osteosarcoma affects both adolescents and adults, some improvement in the survival rate for affected patients has been reached last decade.Still, non-specificity systemic toxicity may limit traditional therapeutic approaches to extent.The insulin growth factor 1 (IGF1) its binding protein (IGFBP3) have implicated tumorigenesis.Nanoparticles, such as graphene oxide (GO), can provide an effective treatment cancer they specifically target cells while reducing undesired side effects.This study...
The present study demonstrated for the first time that SNORA70E, which belongs to box H/ACA small nucleolar noncoding RNAs (snoRNAs) who could bind and induce pseudouridylation of RNAs, was significantly elevated in ovarian cancer tissues an unfavourable prognostic factor cancer. over-expression SNORA70E showed increased cell proliferation, invasion migration vitro induced tumour growth vivo. Further research found regulates RAS-Related Protein 1B (RAP1B) mRNA through pseudouracil...
The transcriptional activation domain of the herpesvirus protein VP16 resides in carboxyl-terminal 78 amino acids (residues 413-490). Fluorescence analyses this indicated that critical are solvent-exposed highly mobile segments. To examine interactions between and components basal machinery, we incorporated (at position 442 or 473 VP16) tryptophan analogs can be selectively excited complexes with other Trp-containing proteins. TATA-box binding (TBP) (but not transcription factor B (TFIIB))...
Diabet. Med. 29, e47–e54 (2012) Abstract Aims Mitochondrial DNA (mtDNA) content is essential for maintaining normal mitochondrial function, and the function critical production release of insulin in Type 2 diabetes mellitus. We investigated whether peripheral blood mtDNA was reduced diabetes, what were major factors? Methods The a sample 147 170 Chinese subjects determined by amplification gene CYT‐B normalized nuclear β‐globin gene. Fasting plasma glucose, HbA 1c , fasting lipid profile...
Although several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconclusive. The high-resolution melting (HRM) analysis was used to determine whether the occurrence of SNPs miR-146a C > G (rs2910164), miR-196a2 T (rs11614913), miR-301b A (rs384262), miR-499 (rs3746444) differs frequency-matched 314 HCC patients 407 controls by age sex. groups' genotype...