A5066063807- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- Essential Oils and Antimicrobial Activity
- Natural Compounds in Disease Treatment
- Malaria Research and Control
- Insect Pest Control Strategies
- Insect behavior and control techniques
- Insect symbiosis and bacterial influences
- Insect Utilization and Effects
- Mosquito-borne diseases and control
- Moringa oleifera research and applications
- Phytochemistry and Biological Activities
- Infectious Diseases and Tuberculosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Bee Products Chemical Analysis
- Histone Deacetylase Inhibitors Research
- Parasites and Host Interactions
- RNA Interference and Gene Delivery
- Fatty Acid Research and Health
- Hedgehog Signaling Pathway Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
University of Douala
2018-2025
University of Cape Town
2015-2022
International Centre for Genetic Engineering and Biotechnology
2015-2022
South African Medical Research Council
2016-2022
Huazhong Agricultural University
2022
International Centre for Genetic Engineering and Biotechnology
2020
Northwest A&F University
2013
Université de Yaoundé I
2009-2011
Abstract The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, type 2 IL-4 demonstrated to play a cognition. In this study, using Morris water maze task, we demonstrate that IL-13–deficient mice are significantly impaired working memory as well attenuated reference memory, functions essential for effective complex learning. During learning process, wild-type increased...
Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen interactions, leading to host protection or pathogenesis. Using a unique transcriptome technology (CAGE), we investigated the promoter-based transcriptional landscape of IFNγ (M1) IL-4/IL-13 (M2) stimulated macrophages during Mtb in time-kinetic manner. widely drastically altered macrophage-specific gene expression, which is far larger than that M1 M2 activations. Gene Ontology enrichment analysis for...
Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct important roles for microbiocidal activity, regulation of inflammation tissue homeostasis. Despite this, their transcriptional regulatory dynamics are poorly understood. Using promoter-level expression profiling by non-biased deepCAGE we have studied the classically macrophages. Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 TBP that...
Mycobacterium tuberculosis (Mtb) can subvert the host defence by skewing macrophage activation towards a less microbicidal alternative activated state to avoid classical effector killing functions. Investigating molecular basis of this evasion mechanism could uncover potential candidates for directed therapy against (TB). A limited number miRNAs have recently been shown regulate host-mycobacterial interactions. Here, we performed time course kinetics experiments on bone marrow-derived...
The emergence of Plasmodium falciparum resistance to artemisinin is a huge concern in Africa. We investigated and characterized mutations Pfk13 propeller sequences from P. isolates across two endemic areas with different eco-geographical settings Cameroon. A total 259 dried blood spot samples were collected through cross-sectional survey health facilities located Bimengue (rural area) the Efoulan District Hospital Yaoundé (urban area). molecular analysis was performed using nested polymerase...
The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it unknown whether its therapeutic effect relates with PCa. Here we described as cells. Our data showed that suppressed cell growth reduced the expression EZH2. Overexpression attenuated induced inhibition. Moreover, treatment PC-3 cells resulted elevated mRNA levels genes (ADRB2,...
Triptolide, an active compound extracted from Chinese herb Leigongteng (Tripterygium wilfordii Hook F.), shows a broad-spectrum of anticancer activity through its cytotoxicity. However, the efficacy triptolide on laryngocarcinoma rarely been evaluated, and mechanism by which triptolide-induced cellular apoptosis is still not well understood. In this study, we found that significantly inhibited HEp-2 cells proliferation, migration survivability. Triptolide induces cell cycle arrest at G1...
Background: Triptolide is a medicinal herb-derived diterpene triepoxide with potent anti-tumor activity, mainly ,correlated its ability to inhibit and inactivate subunits of RNA polymerase II, thereby suppressing global gene transcription. Epigenetic imbalance including histone methylation are well known play important roles in prostate cancer (PCa) onset progression. The goal this study was investigate whether triptolide might exert anti-PCa influence by reshaping the landscape. Methods:...
Triptolide is a diterpene triepoxide, which performs its biological activities via mechanisms including induction of apoptosis, targeting pro-inflammatory cytokines, and reshaping the epigenetic landscape target cells. However, long non-coding RNAs (lncRNAs) by triptolide has not yet been investigated, despite their emerging roles as key regulators inflammation immune cell function during Mycobacterium tuberculosis (Mtb) infection. Hence, we investigated whether targets...
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance current antimicrobials. Noncoding RNAs are emerging important regulators of numerous biological processes avenues exploitation in host-directed therapeutics. Although long noncoding (lncRNAs) abundantly expressed immune cells, their functional role gene regulation...
Hookworm infection is endemic in developing countries, leading to poor cognitive function-among other disruptions. In this study, the effects of Nippostrongylus brasiliensis (a murine model Necator Americanus) on function were investigated. Though impaired cognition has been extensively reported, exact domain affected still unknown, hence requiring investigation. The objective study was identify possible changes during mice, using Morris water maze. Here, we show for first time that mice...
MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified a critical regulatory mechanism the immune system. Despite great efforts made to discover characterize ncRNAs, role for most remains unknown. To facilitate discoveries regulation system-related processes, we developed database immunologically relevant ncRNAs target genes...
Due to their significant health benefits, fish oils have garnered increasing interest in recent decades. However, Cameroon’s oil market remains insignificant, and the few available products are imported, despite country’s abundant marine resources. Additionally, research on Cameroonian is relatively scarce. Therefore, this manuscript provides an overview of Cameroon, focusing physicochemical characteristics, as well nutritional biological properties. As March 2023, 26 studies Cameroon been...
Promyelocytic leukaemia zinc finger (Plzf), also known as and BTB domain containing 16 (ZBTB16) or zinc-finger protein 145 (ZFP145), is a critical of male germline stem cells (mGSCs). Multiple lines evidence indicate that Plzf has central role in the development, differentiation maintenance many cells, including mGSCs, been validated an essential transcription factor for mammalian testis development spermatogenesis. This review summarises current literature focusing on significance...
Objective. The aim of this study was to determine the chemical characteristics and antibacterial activity Fontitrygon margarita liver oil against bacteria responsible for food poisoning. Methods. Oils were extracted from F. using two methods (exudation cooking-pressing) analyses by Fourier transform infrared (FTIR) spectroscopy. Quality indexes determined standard fatty acid profile carried out gas chromatography with a flame ionization detector (GC-FID). Antibacterial activities these oils,...
Abstract RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid degradation and targeting of individual tissues. Injectable hydrogels are one potentially simple direct route towards overcoming these barriers. Here we report on the utility combination mildly modified form clinically utilised fibrin hydrogel with Invivofectamine® 3.0, lipid nonviral transfection vector, for local sustained release. PEGylation allowed controlled release...