A5003678597- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Planarian Biology and Electrostimulation
International Centre for Genetic Engineering and Biotechnology
2017-2018
South African Medical Research Council
2017
University of Cape Town
2017
Abstract The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, type 2 IL-4 demonstrated to play a cognition. In this study, using Morris water maze task, we demonstrate that IL-13–deficient mice are significantly impaired working memory as well attenuated reference memory, functions essential for effective complex learning. During learning process, wild-type increased...
Hookworm infection is endemic in developing countries, leading to poor cognitive function-among other disruptions. In this study, the effects of Nippostrongylus brasiliensis (a murine model Necator Americanus) on function were investigated. Though impaired cognition has been extensively reported, exact domain affected still unknown, hence requiring investigation. The objective study was identify possible changes during mice, using Morris water maze. Here, we show for first time that mice...