A5102846983- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Eosinophilic Disorders and Syndromes
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- Glycosylation and Glycoproteins Research
- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Chemical and Physical Properties in Aqueous Solutions
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2016-2025
Air Force Medical University
2013-2025
Xijing Hospital
2013-2025
National Clinical Research
2020-2024
National Clinical Research Center for Digestive Diseases
2022
Nanjing Medical University
2015
Suzhou Research Institute
2015
China Medical University
2008-2014
Tianjin University
2008-2011
Cancer cells respond to various stressful conditions through the dynamic regulation of RNA m6A modification. Doxorubicin is a widely used chemotherapeutic drug that induces DNA damage. It interesting know whether cancer regulate damage response and doxorubicin sensitivity Here, we found treatment significantly induced methylation in breast both dose- time-dependent manner. However, protein arginine methyltransferase 5 (PRMT5) inhibited modification under by enhancing nuclear translocation...
Chromosomal translocations are a genomic hallmark of many hematologic malignancies. Often as initiating events, these structural abnormalities result in fusion proteins involving transcription factors important for hematopoietic differentiation and/or signaling molecules regulating cell proliferation and cycle. In contrast, epigenetic regulator genes more frequently targeted by somatic sequence mutations, possibly secondary events to further potentiate leukemogenesis. Through comprehensive...
Lapatinib, a novel tyrosine kinase inhibitor of HER2/EGFR, is used to treat HER2-positive breast cancer. However, acquired drug resistance has limited the clinical therapeutic efficacy lapatinib. Our previous study found that inhibition autophagy can reduce proliferation, DNA synthesis, and colony-forming capacity lapatinib-resistant cells. Berberine attracted extensive attention due its wide range biochemical pharmacological effects in cancer treatment. It been reported berberine induce...
Abstract Metallic nanoparticles (NPs) have potential applications in industry and medicine, but they also the to cause many chronic pulmonary diseases. Mechanisms for their cytotoxicity, glucose energy metabolism responses need be fully explained lung epithelial cells after treatment with metallic nanoparticles. In our study, two different (Fe 2 O 3 ZnO) cell‐based assays (BEAS‐2B A549 cell lines) were used. Our findings demonstrate that ZnO nanoparticles, not Fe induce cycle arrest,...
Stroke is the second most frequent cause of mortality, resulting in a huge societal burden worldwide. Timely reperfusion effective therapy; however, it difficult to prevent ischemia/reperfusion (I/R) injury. In traditional Chinese medicine, hydroxysafflor yellow A (HSYA) has been widely used for treatment cerebrovascular disease and as protective therapy against I/R Evidence demonstrated that HSYA could reduce levels reactive oxygen species suppress cellular apoptosis; whether alters...
ABSTRACT Tamoxifen is one of the most frequently used endocrine medications for treatment estrogen receptor‐positive (ER + ) breast cancer (BC). Unfortunately, tamoxifen resistance (TR) brings more challenges to clinical treatment, and mechanisms TR have not yet been fully clarified. HGF/c‐Met closely associated with metastasis, but whether it involved in remains unclear. In our study, we found that activation was crucial maintenance. Synergistic interaction HOTAIR EZH2 accelerated HGF...
Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (Ph-negative BCP-ALL) accounts for a significant portion of adult cases. Blinatumomab, bispecific T-cell engager, has shown efficacy in relapsed or refractory BCP-ALL, but its role induction therapy with reduced-dose chemotherapy is being explored. In this retrospective study, 35 newly diagnosed Ph-negative BCP-ALL patients received followed by two weeks blinatumomab (RDC-Blinatumomab-2W) as part our previous clinical...
Abstract Background NDRG 2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that expressed differentially normal and cancer tissues. Specifically, mRNA down-regulated or undetectable several human cancers, over-expression of inhibited the proliferation cells. also exerts important functions cell differentiation tumor suppression. However, it remains unclear whether participates carcinogenesis thyroid. Methods In this study, we...
Amitriptyline is a classic tricyclic antidepressant (TCA) and has been used to treat the depression anxiety of patients with cancer, but its relevance cancer cell apoptosis not known. In present study, we demonstrated that amitriptyline inhibited cyclin D2 transactivation displayed potential antimyeloma activity by inhibiting histone deacetylases (HDACs). markedly decreased promoter-driven luciferase activity, reduced expression, arrested cells at G<sub>0</sub>/G<sub>1</sub> phase cycle....
Abstract Docetaxel is commonly used as an effective chemotherapeutic agent in breast cancer treatment, but the underlying mechanisms of drug resistance are not fully understood. The purpose this study was to investigate possible role miR-129-3p cell docetaxel. MiR-129 and inhibitor were transfected into cells their effects on chemoresistance function evaluated by apoptosis, proliferation cycle assays. We found that up-regulated MDA-MB-231/Doc cells, concurrent with CP110 down-regulation,...
ABSTRACT HER2‐overexpressing breast cancers often show hyperactivation of the HER2/AKT/mTOR signaling pathway. Lapatinib is an oral dual tyrosine kinase inhibitor (TKI) that targets both EGFR and HER2 to inhibit proliferation cancer cells. However, it obscure whether how lapatinib could induce autophagy in cells, important cell response with drug treatment. In this study, we investigated apoptosis cells BT474 AU565 treated lapatinib, further examined their relationship. inhibited rate DNA...
Lapatinib, a tyrosine kinase inhibitor of HER2/EGFR, can inhibit the proliferation HER2-positive breast cancer cells. Additionally, combination lapatinib and chemotherapy markedly prolong patient survival time. However, clinical therapeutic effect is severely limited by drug resistance. We previously found that brief treatment with induced both apoptosis autophagy in was dependent on autophagy. In our current study, however, we used extended cells to confirm presence protective established...
Abstract The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti- Cancer Association. This portion the for adult acute myeloid leukemia (AML) not only focuses on diagnosis, treatment options younger (age < 60 years) and older ≥ patients (including non-APL, APL, R/R AML), but also pay attention to AML complications, including central nervous system (CNSL), cardiotoxicity, agranulocytosis fever, hepatitis B virus reactivation, uric acid nephropathy, bleeding...