A5010046191- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Bone Tissue Engineering Materials
- Dental materials and restorations
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Polymer Surface Interaction Studies
- Spinal Cord Injury Research
- Adhesion, Friction, and Surface Interactions
- Neural Networks Stability and Synchronization
- Cancer-related gene regulation
- Bone and Dental Protein Studies
- Distributed Control Multi-Agent Systems
- Axon Guidance and Neuronal Signaling
- Stability and Control of Uncertain Systems
- Terahertz technology and applications
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Advanced Surface Polishing Techniques
- Anesthesia and Neurotoxicity Research
Air Force Medical University
2015-2025
Jiangxi Agricultural University
2022-2025
Innovation Team (China)
2022
China Academy of Transportation Sciences
2019
Nanjing Tech University
2019
China Information Technology Security Evaluation Center
2018
Cincinnati Children's Hospital Medical Center
2017
Peking University
2013-2016
81th Hospital of PLA
2016
Nanjing University of Chinese Medicine
2016
Notch signaling is critically involved in neural development, but the downstream effectors remain incompletely understood. In this study, we cultured neurospheres from Nestin-Cre-mediated conditional Rbp-j knockout (Rbp-j cKO) and control embryos compared their miRNA expression profiles using microarray. Among differentially expressed miRNAs, miR-342-5p showed upregulated as was genetically or pharmaceutically interrupted. Consistently, promoter of host gene, Ena-vasodilator stimulated...
The ten‐eleven translocation (TET) family of methylcytosine dioxygenases catalyze oxidation 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) and promote DNA demethylation. Despite the abundance 5hmC TET proteins in brain, little is known about their role oligodendrocytes (OLs). Here, we analyzed expression during OL development vivo vitro , found that three members possess unique subcellular temporal patterns. Furthermore, level exhibits dynamic changes maturation, which implies...
Stroke is the second most frequent cause of mortality, resulting in a huge societal burden worldwide. Timely reperfusion effective therapy; however, it difficult to prevent ischemia/reperfusion (I/R) injury. In traditional Chinese medicine, hydroxysafflor yellow A (HSYA) has been widely used for treatment cerebrovascular disease and as protective therapy against I/R Evidence demonstrated that HSYA could reduce levels reactive oxygen species suppress cellular apoptosis; whether alters...
Abstract Ten-eleven translocation (TET) proteins, the dioxygenase for DNA hydroxymethylation, are important players in nervous system development and diseases. However, their role myelination remyelination after injury remains elusive. Here, we identify a genome-wide locus-specific hydroxymethylation landscape shift during differentiation of oligodendrocyte-progenitor cells (OPC). Ablation Tet1 results stage-dependent defects oligodendrocyte (OL) mouse brain. The mice lacking lineage develop...
Purpose The purpose of this paper is to explore an application computer‐aided design and manufacture (CAD/CAM) a process electronically surveying scanned dental cast as prior stage producing sacrificial pattern for removable partial denture (RPD) metal alloy framework. Design/methodology/approach With the introduction laser scan technology commercial reverse engineering software, standard plaster maxillary with dentition defect was successfully created STL‐formatted digital cast. unwanted...
The generation of myelinating cells from multipotential neural stem in the CNS requires initiation specific gene expression programs oligodendrocytes (OLs). We reasoned that microRNAs (miRNAs) could play an important role this process by regulating genes crucial for OL development. Here we identified miR-7a as one highly enriched miRNAs oligodendrocyte precursor (OPCs), overexpression which either progenitor (NPCs) or embryonic mouse cortex promoted lineage cells. Blocking function...
Myelinogenesis is a complex process that involves substantial and dynamic changes in plasma membrane architecture myelin interaction with axons. Highly ramified processes of oligodendrocytes the central nervous system (CNS) make axonal contact then extrapolate to wrap around axons form multilayer compact sheathes. Currently, mechanisms governing sheath assembly axon selection by myelinating cells are not fully understood. Here, we generated transgenic mouse line expressing membrane-anchored...
Terahertz (THz) frequency occupies a large portion of the electromagnetic spectrum that is between infrared and microwave regions. Recent advances in THz application have stimulated interests regarding biological effects within this range. In current study, we report irradiation with single-frequency laser on mice cortical neuron cultures increases excitatory synaptic transmission neuronal firing activities. Microarray assay reveals gene expression dynamics after exposure, which consistent...
Abstract Ca 2+ signaling is essential for oligodendrocyte (OL) development and myelin formation. Inositol 1,4,5‐trisphosphate receptor type 2 (ITPR2) an endoplasmic reticulum calcium channel shows stage‐dependent high levels in postmitotic precursor cells (OPCs). The role potential mechanism of ITPR2 OLs remain unclear. In this study, it revealed that loss Itpr2 disturbs homeostasis inhibits myelination adolescent mice. Animals with OL‐specific deletion exhibit anxiety/depressive‐like...
Ti-24Nb-4Zr-7.9Sn (TNZS) is a newly developed beta-titanium alloy with low modulus and it has been considered as good material for dental or orthopedic implant. The purpose of the current study to evaluate effect micro-arc oxidation (MAO) treatment on biological performance TNZS surface. phases, morphology chemical composition MAO-treated surface were characterized by X-ray diffraction, energy dispersive spectroscope scanning electron microscopy analysis respectively. Then we tested...
A variety of neurological and psychiatric disorders have recently been shown to be highly associated with the abnormal development function oligodendrocytes (OLs) interneurons. OLs are myelin-forming cells in central nervous system (CNS), while interneurons important neural types gating excitatory neurons. These two great significance for establishment circuits, they share similar developmental origins transcriptional architectures, interact each other multiple ways during development. In...
MicroRNA-124 (miR-124) is abundantly expressed in neurons the mammalian central nervous system, and plays critical roles regulation of gene expression during embryonic neurogenesis postnatal neural differentiation. However, profile miR-124 after spinal cord injury underlying regulatory mechanisms are not well understood. In present study, we examined mouse brain using situ hybridization. Furthermore, was with quantitative RT-PCR at 1, 3 7 days injury. The site evaluated by hybridization...
Abstract: Titanium implants have been widely used for many medical applications, but bacterial infection after implant surgery remains one of the most common and intractable complications. To this end, long-term antibacterial ability surface is highly desirable to prevent implant-associated infection. In study, a novel coating containing new agent, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone loaded poly(L-lactic acid) nanoparticles, was fabricated on microarc-oxidized titanium purpose....
Abstract Myelin sheaths, which insulate the axons and ensure saltatory conduction of nerve impulse, are generated maintained via largely uncharacterized mechanisms. Ermin is an oligodendrocyte‐specific protein associated with cytoskeleton, but how it regulates cytoskeletal remodeling during oligodendrocyte differentiation its role in myelin maintenance not clear. To address this, we mice constitutively deficient for Ermn , Ermin‐coding gene. We found that aged ‐knockout exhibit aberrant...