A5053061701- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Complement system in diseases
- Intergenerational Family Dynamics and Caregiving
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Psoriasis: Treatment and Pathogenesis
- Hematopoietic Stem Cell Transplantation
- Health disparities and outcomes
- Migration, Aging, and Tourism Studies
- Hematological disorders and diagnostics
- Retirement, Disability, and Employment
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Workplace Health and Well-being
- Cancer Mechanisms and Therapy
- Blood groups and transfusion
- Pharmaceutical studies and practices
- Adenosine and Purinergic Signaling
- Global Health Care Issues
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
Tianjin Medical University General Hospital
2010-2025
Waseda University
2016-2025
Shandong University of Traditional Chinese Medicine
2021-2025
China Pharmaceutical University
2024-2025
Tianjin Medical University
2010-2024
Nankai University
2024
Hangzhou Dianzi University
2024
Qiqihar Medical University
2019-2024
Arrowhead Pharmaceuticals (United States)
2024
Nanjing Medical University
2021-2024
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes patients with refractory and recurrent malignancies blood. However, achieving sustainable long-term complete remission for blood cancer remains a challenge, resistance relapse being expected many patients. Although studies have attempted to clarify mechanisms cell therapy failure, mechanism unclear. In this article, we discuss describe current state knowledge regarding these factors, which...
We evaluate a spillover effect of the Japanese public long-term care insurance (LTCI) as policy to stimulate family caregivers' labor force participation. Using nationally representative data from 1995 2013, we apply difference-in-difference propensity score matching investigate in two periods: before and after introduction LTCI 2000 its major amendment 2006. Our results show that has significant positive effects on participation vary by gender age. In contrast, is found have generally...
Objectives This study focuses on East Asian countries and investigates the difference in marriage premium health-marriage protection effect (MPE) between younger older generations intra-couple education concordance (ECE) health of married individuals. used inter-country comparative data from China, Japan, Korea. Methods focused individuals (n = 7,938) Korea who were sampled 2010 Social Survey. To investigate MPE ECE, four indicators utilized: a physical mental components summary (PCS MCS),...
The microstructural evolution during homogenization treatment and the recrystallization behavior caused by Al3Zr precipitate in 2195 alloy were investigated via scanning electron microscopy, X-ray diffraction, transmission microscopy backscatter diffraction. severe dendrite segregation as-cast was removed homogenization, but process limited slower dissolution of Al–Cu phases. Moreover, dispersoids precipitated sample homogenized ramp heating rate 30 °C/h (H30) finer denser compared to...
Abstract Background: Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there need for new treatment regimens. In this study, we assessed efficacy and safety secukinumab in with moderate to severe plaque psoriasis. Methods: This study was 52-week, multicentre, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 trial. A sub-population participants (≥18...
The 2195 Al-Li alloy was processed by under-aging (UA), peak-aging (PA), double-aging (DA) and retrogression re-aging (RRA) treatments, the microstructure, intergranular corrosion (IGC), exfoliation (EXCO) stress cracking (SCC) behaviors were observed discussed. results show that sequence of IGC EXCO resistance is: RRA > UA DA PA. low PA is mainly caused continuous precipitation T1 phases at grain boundaries to form channels, while interruption channels coarse discontinuous wider precipitate...
Abstract Aims Crovalimab is a novel C5 inhibitor administered first intravenously and then subcutaneously in patients with paroxysmal nocturnal haemoglobinuria (PNH) naive to complement inhibition or switching from eculizumab ravulizumab. showed efficacy safety comparable the pivotal COMMODORE 2 supporting studies. Methods We characterized crovalimab pharmacokinetics relationship between exposure pharmacokinetic parameters pharmacodynamic biomarkers, endpoints using pooled data (healthy...
aShandong University of Traditional Chinese Medicine First Clinical Medical College, Jinan, China bShandong Affiliated Hospital, *Corresponding author. Address: Shandong China. Tel.: +86 1900541a7980. E-mail: [email protected] (X. Li). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided original work properly cited.
Objective Phosphoglycerate kinase 1 (PGK1) was previously screened as a possible autoantigen for IRP, this study further investigates the value of PGK1 autoantibodies in diagnosis IRP and their correlation with other clinical indicators.
Few studies have addressed the relationship between sleep and employment in Japan. We use four waves of Japan Study Aging Retirement (JSTAR) to address weekday duration, self-reported quality indicators status (model 1, full sample), working hours job satisfaction 2, sample) among individuals aged 50 over (N=7,082). apply mixed effects models for linear outcome duration cumulative link variables, controlling socio-demographic health characteristics. In model our findings show that, compared...
<title>Abstract</title> This study examines healthcare utilization patterns among Japan’s older population (aged 75 and above) during a prolonged public health emergency, focusing on the later phase of COVID-19 pandemic (November 2021-September 2022). period was characterized by Omicron variant, widespread vaccination coverage, adapted measures. Using comprehensive dataset 189,841,257 medical claims linked with income tax records, we analyze how correlates measures, severity, levels. Our...
<title>Abstract</title> Severe aplastic anemia is a life-threatening ineffective hematopoiesis, arising from inherited or acquired traits. Wilson disease rare congenital metabolic disorder with copper accumulation. Here we report case of 15 year-old boy, who presented bone marrow failure. Whole exome sequencing revealed several gene mutations in ATP7B and TERT. Based on the phenotypes, telomere lengths pedigree his family, patient was diagnosed accompanied by disease. Allogeneic...
Abstract This study examines the impact of reducing formal care benefits on well-being informal caregivers, contributing to ongoing discourse about establishing sustainable and adequate levels care. We utilize a reform introduced in Japan’s public long-term insurance system, which curtailed for group recipients with low needs. Employing difference-in-difference approach fixed effects nationally representative sample coresident we explore both overall temporal this reform. Our findings reveal...
The urban-rural health disparity poses a significant challenge for countries worldwide. China encounters substantial disparities in healthcare services and outcomes between urban rural regions. In 2015, the Chinese government integrated medical insurance schemes residents into unified program, with goal of mitigating enhancing sustainability efficiency system. Using data from Health Retirement Longitudinal Study (CHARLS), we explored impact this integration on residents, employing triple...
It is widely documented that psychological distress negatively associated with social networks involvement. However, despite the theoretical postulations are crucial for alleviating distress, no study has yet empirically confirmed causality of this relationship. Thus, we used random-effects generalized least squares method to investigate effect one- and two-year lagged values involvement in on distress. Nine years longitudinal data were extracted from a nationally representative survey Japan...
The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, the role of sphingolipid metabolism in this effect remains unclear.