A5032405800- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Effects and risks of endocrine disrupting chemicals
- Ubiquitin and proteasome pathways
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Pituitary Gland Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Diabetes Treatment and Management
- Hormonal and reproductive studies
- Lipid metabolism and disorders
- Eicosanoids and Hypertension Pharmacology
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
China Pharmaceutical University
2025
Ningxia Medical University
2025
Sir Run Run Shaw Hospital
2024
Zhejiang University
2023-2024
Zunyi Medical University
2024
Chongqing University
2024
Adrenal vein sampling (AVS) is the recommended procedure for subtyping primary aldosteronism (PA) as unilateral PA (UPA) or bilateral (BPA), with different treatment needed each: adrenalectomy UPA and medication BPA. However, AVS invasive technically difficult, how to subtype noninvasively currently a great challenge.To evaluate accuracy of gallium-68 pentixafor positron emission tomography-computed tomography (PET-CT) in using reference standard.This diagnostic study was conducted at...
The diagnosis of primary aldosteronism typically requires at least one confirmatory test. fludrocortisone suppression test is generally accepted as a reliable test, but it cumbersome. Evidence from accuracy studies the saline infusion (SIT) and captopril challenge (CCT) has provided conflicting results. This prospective study aimed to evaluate diagnostic SIT CCT using reference standard. One hundred thirty-five patients diagnosed with 101 essential hypertension who completed 3 tests were...
Background and Aims Indole is a microbiota metabolite that exerts anti‐inflammatory responses. However, the relevance of indole to human non‐alcoholic fatty liver disease (NAFLD) not clear. It also remains largely unknown whether how acts protect against NAFLD. The present study sought examine association between circulating levels fat content in subjects explore mechanisms underlying actions mice with diet‐induced Approach Results In cohort 137 subjects, were reversely correlated body mass...
With the widespread use of advanced imaging technology, adrenal tumors are increasingly being identified.To investigate prevalence and characteristics in an unselected screening population China.Cross-sectional study. (ClinicalTrials.gov: NCT04682938).A health examination center China.Adults having annual checkup were invited to be screened for by computed tomography.The participants with had further evaluation malignancy risk function.A total 25 356 screened, 351 whom found have tumors, a...
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Neutrophil extracellular traps (NETs) are a network structure composed loose chromatin and embedded with multiple proteins. Here, we observed increased NETs deposition in glomeruli DKD patients diabetic mice (streptozotocin-induced or db/db mice). After were degraded DNase I, exhibited attenuated glomerulopathy glomerular endothelial cells (GECs) injury. We also alleviated GECs injury peptidylarginine deiminase...
The Chinese visceral adiposity index (CVAI) is a recently developed indicator of adiposity. We investigated the predictive value CVAI for development dysglycemia (pre-diabetes and type 2 diabetes) compared its power with that Visceral (VAI) various anthropometric indices. This community-based study included 2,383 participants. assessed indices by performing univariate multivariate binary logistic regression analysis calculating area under receiver-operating characteristic (ROC) curve...
Diabetic kidney disease (DKD) lacks a simple and relatively accurate predictor. The Triglyceride-Glucose (TyG) Index is proxy of insulin resistance, but the association between TyG DKD less certain. We investigated if can predict onset effectively.Cross-sectional longitudinal analyses were undertaken. In total, 1432 type-2 diabetes mellitus (T2DM) patients included in cross-sectional analysis. (calculated by ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]) was split into three...
Perirenal fat is adjacent to kidneys and active in metabolism adipokine secretion. We aimed investigate whether perirenal an independent predictor for chronic kidney disease (CKD) compared it with total, subcutaneous, or visceral patients diabetes. thickness (PRFT) was measured by computed tomography, total body (TBF), subcutaneous adipose tissue (SAT), (VAT) were assessed DEXA. In cross-sectional analysis, higher PRFT had a lower estimated glomerular filtration rate (eGFR). Multiple linear...
Angiotensin receptor blockers (ARBs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been used as the standard therapy for patients with diabetic kidney disease (DKD). However, how these two drugs possess additive renoprotective effects remains unclear. Here, we conducted single-cell RNA sequencing to profile cell transcriptome of db/db mice treated vehicle, ARBs, SGLT2i, or ARBs plus using db/m control. We identified 10 distinct clusters cells predominant proximal tubular (PT)...
It was reported that the Wnt/β-catenin pathway is involved in regulation of aerobic glycolysis and brain glycolytic dysfunction results development Alzheimer's disease (AD). Icariin (ICA), an active component extracted from Epimedii Folium, has been to produce neuroprotective effects multiple models AD, but its underlying mechanism remains be fully described. We aimed investigate protective ICA on animal cell AD confirm whether functions function ICA. The 3 × Tg-AD mice were treated with...
Aim . This retrospective study is aimed at investigating whether aldosterone-renin ratio (ARR) cutoffs calculated by the plasma aldosterone concentration (PAC)/plasma renin (PRC) should be set differently in patients of different ages. Methods 521 hypertensive were screened for primary aldosteronism (PA) PAC/PRC. 174 diagnosed with PA and 311 essential hypertension (EH) included final analysis. Subjects subdivided into four age groups: <40, 40–49, 50–59, ≥60 years old. Results The...
Objective: To explore the quantitative value of T2mapping sequence in evaluating early glenohumeral joint cartilage injury. Methods: A total 92 patients with shoulder pain who underwent routine and scanning General Hospital Ningxia Medical University from March 2023 to 2024 were retrospectively collected as a case group. The classified into tendinitis group, partial tear group full according degree tendon Another 25 healthy subjects same age selected control Two physicians divided articular...
Objective: To evaluate the safety and efficacy of mitoxantrone liposome (MIT-LIP) combined chemotherapy in treating mixed phenotype acute leukemia (MPAL) . Methods: December 2021 to November 2024, MPAL patients who underwent MAED (MIT-LIP + cytarabine etoposide dexamethasone) regimen were retrospectively analyzed. Data on clinical characteristics, adverse reactions, therapeutic outcomes, long-term prognoses collected. Results: A total 7 received admitted. Among them, two initially diagnosed...
Abstract Context The Endocrine Society Guidelines for the diagnosis of primary aldosteronism (PA) suggest that confirmatory tests (CFT) are not required when following criteria met: plasma aldosterone concentration (PAC) is &gt;20 ng/dL, renin below detection levels, and hypokalemia present. evidence applicability guideline limited. Objective To develop validate optimized sparing CFT in PA. Design Setting were developed a Chinese cohort using captopril challenge test, verified by saline...
The present study was designed to determine the relationships between sarcopenia and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM) foot disease (DFD) respectively.A total of 1104 T2DM 257 DFD were included study, which as a cross-sectional study. Body composition assessed using dual-energy X-ray-absorptiometry (DXA). diagnosis based on Baumgartner criteria. DPN by Neuropathy symptom score (NSS) disability (NDS), severity divided into non-neuropathy...