A5085446360- Viral Infections and Immunology Research
- Thyroid Cancer Diagnosis and Treatment
- interferon and immune responses
- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- Photodynamic Therapy Research Studies
- NF-κB Signaling Pathways
- Hemophilia Treatment and Research
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Birth, Development, and Health
- Thyroid and Parathyroid Surgery
- Cytokine Signaling Pathways and Interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Medical Imaging and Pathology Studies
- Insect symbiosis and bacterial influences
First Affiliated Hospital of Zhengzhou University
2014-2025
Zhejiang University
2013-2024
Hangzhou Medical College
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Zhejiang Provincial People's Hospital
2024
First Affiliated Hospital Zhejiang University
2015-2024
Shanghai Jiao Tong University
2012-2023
Shanghai Institute of Hematology
2023
Shanghai Chest Hospital
2010-2022
Vascular calcification is the formation of mineralised tissue within walls arteries and associated with increased cardiovascular morbidity mortality. The pathology involves osteogenic differentiation vascular smooth muscle cells (VSMCs) matrix mineralisation. development has many similarities to bone formation; although exact mechanisms are not fully understood. Recent studies have demonstrated that bioactive sphingolipids, ceramide sphingosine-1-phosphate (S1P), regulators formation. levels...
Camrelizumab and chemotherapy demonstrated durable antitumor activity with a manageable safety profile as first-line treatment in patients advanced esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the efficacy of camrelizumab plus neoadjuvant chemotherapy, using pathologically complete response (pCR) primary endpoint, for locally ESCC.Patients but resectable thoracic ESCC, staged T1b-4a, N2-3 (≥3 stations), M0 or M1 lymph node metastasis (confined supraclavicular...
Significance The cuticle, mainly composed of chitin and cuticular proteins (CPs), is a multifunctional structure arthropods. CPs usually account for >1% the total insect encoded in genome. Why does an need so many different CPs? In this study, we use comprehensive large-scale technologies to study full complement their functions brown planthopper (BPH). A 32 140 BPH CP genes are found be essential nymph/adult development, egg production, or embryo development; addition, redundant...
Purpose: To compare the efficacy of four different ultrasound-based risk-stratification systems in assessing malignancy risk thyroid nodules Chinese population. Methods: We retrospectively reviewed digital ultrasound images 1568 patients (1612 nodules) who underwent surgery our hospital between January 2012 and December 2017. All were pathologically identified as malignant or benign. evaluated following characteristics: size, location, composition, echogenicity, shape, margins, calcification...
Diabetic kidney disease (DKD) lacks a simple and relatively accurate predictor. The Triglyceride-Glucose (TyG) Index is proxy of insulin resistance, but the association between TyG DKD less certain. We investigated if can predict onset effectively.Cross-sectional longitudinal analyses were undertaken. In total, 1432 type-2 diabetes mellitus (T2DM) patients included in cross-sectional analysis. (calculated by ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]) was split into three...
Background Several metals have been reported to be associated with childhood asthma. However, the results on relationships between and risk of asthma are inconclusive, research adult in Chinese general population is rare. Objectives To investigate potential associations levels urinary Methods A case-control study 551 cases gender- age-matched controls was conducted Wuhan, China. Demographic information obtained, lung function assessed. The concentrations 22 were measured by inductively...
Abstract Hundreds of insect genome sequences have been reported; however, most sequencing projects not determined the sex chromosomes, and no Y chromosomes from a heterometabolous identified characterized to date. The brown planthopper ( Nilaparvata lugens Stål) is economically damaging pest rice also an ideal research subject for paddy ecology functional genomics. We previously assembled draft female mainly using second‐generation technologies, with contig N50 only 24 kb, due large size...
Obesity and type 2 diabetes (T2D) are both complicated endocrine disorders resulting from an interaction between multiple predisposing genes environmental triggers, while diet exercise have key influence on metabolic disorders. Previous reports demonstrated that 2-aminoadipic acid (2-AAA), intermediate metabolite of lysine metabolism, could modulate insulin secretion predict T2D, suggesting the role 2-AAA in glycolipid metabolism. Here, we showed treatment diet-induced obesity (DIO) mice...
Abstract A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs lung cancer remain largely unexplored. In the present study, we a novel RNA, hsa_circ_103820, Gene Expression Omnibus (GEO) data. Functionally, overexpression hsa_circ_103820 showed significant inhibitory effects proliferation, migration invasion cells, knockdown played promoting roles. Regarding mechanism, revealed that...
ABSTRACT Coxsackievirus group B type 3 (CVB3) is an important cause of viral myocarditis. The infiltration mononuclear cells into the myocardial tissue one key events in Immediately after CVB3 infects heart, expression chemokine(s) by infected may be first trigger for inflammatory and immune response. However, it unknown whether can induce chemokine cardiac myocytes. Monocyte chemoattractant protein 1 (MCP-1) a potent that stimulates migration cells. objective present study was to...
Background: Sorafenib has shown promise in the treatment of patients with advanced or metastatic thyroid carcinoma. However, optimal dose not been established and data on Chinese population are available. We conducted a study to assess responses sorafenib at low 200 mg twice daily progressive radioiodine-refractory pulmonary metastases from papillary carcinoma (PTC). Patients Methods: Eligible received orally daily. Responses were assessed using Response Evaluation Criteria Solid Tumors...
Platelet to lymphocyte ratio (PLR) is a prognostic factor for various tumors, but the current opinion on value of PLR in liver transplantation (LT) hepatocellular carcinoma (HCC) still controversial. The aim this study was investigate pre-transplant predicting post-LT HCC recurrence and further evaluate correlation with tumor-related characteristics.The clinical data 343 LT retrospectively analyzed. receiver operating characteristic (ROC) curve used determine optimal cut-off predict after...
Abstract While the intrauterine environment is essential for health of offspring, impact high maternal serum estradiol (E 2 ) on lipid metabolism in offspring and mechanisms are unknown. We found that ovarian stimulation (OS) could result E levels women throughout pregnancy. Strikingly, their newborns showed elevated total cholesterol (TC) low-density lipoprotein (LDL-C) were positively related with newborns. In vitro , dose-dependently stimulated TC LDL-C secretion increased expression...
Glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes are administered by daily injection because short plasma half-lives, which result partly from biochemical instability these peptides. There is a medical need GLP-1 analogues that can be less frequently patient convenience.We synthesized series human (hGLP-1(7-36)NH(2) ) derivatives containing α-aminoisobutyric acid (Aib) substitutions, analysed their enzymatic stabilities and evaluated secondary structures...
Background: Sorafenib has shown promise in the treatment of patients with advanced or metastatic thyroid carcinoma. However, its therapeutic effect not been assessed brain metastases from follicular carcinoma (FTC). Here, we report a patient whom this was employed relatively favorable response. Patient and Methods: A 56-year-old woman had thyroidectomy 8 years previously for FTC. She subsequently developed lung metastases, which she received seven courses radioiodine (131I) therapy. right...