A5026259096- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- Medical Imaging and Pathology Studies
- Pituitary Gland Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Adrenal and Paraganglionic Tumors
- Drug Transport and Resistance Mechanisms
- Cell Adhesion Molecules Research
- Bone health and treatments
- Lung Cancer Research Studies
- Protease and Inhibitor Mechanisms
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
University of Naples Federico II
2016-2025
Federico II University Hospital
2014-2024
Princess Alexandra Hospital
2019
National Research Council
2006-2019
Institute of Biostructure and Bioimaging
2006-2019
The University of Queensland
2019
Fiona Stanley Hospital
2017
National Academies of Sciences, Engineering, and Medicine
2000-2015
SDN Istituto di Ricerca Diagnostica e Nucleare
1989-2015
Istituti di Ricovero e Cura a Carattere Scientifico
2015
New imaging techniques have been introduced to assess the extent and severity of disease in multiple myeloma (MM) patients. The aim our study was compare newer modalities—such as <sup>18</sup>F-FDG PET/CT, <sup>99m</sup>Tc-methoxyisobutylisonitrile (<sup>99m</sup>Tc-MIBI) scintigraphy, MRI—to their relative contribution evaluation MM patients at diagnosis. <b>Methods:</b> Thirty-three newly diagnosed with were prospectively studied. Diagnosis staging made according standard criteria. All...
<sup>18</sup>F-FDG PET/CT allows the direct measurement of metabolic tumor burden in a variety different malignancies. The aim this study was to assess whether volume (MTV) determined by could be used prediction progression-free and overall survival multiple myeloma patients. <b>Methods:</b> Forty-seven patients (18 women, 29 men; mean age ± SD, 63 11 y) with stage IIIA disease who had undergone whole-body were retrospectively evaluated. Images underwent 3-dimensional region-of-interest...
One of the hallmarks cancer cells is excessive conversion glucose to lactate under normoxic conditions, also known as Warburg effect. Here, we tested whether targeted inhibition EGFR may revert this effect and reactivate mitochondrial oxidative phosphorylation in non-small cell lung (NSCLC).Sensitive (HCC827) resistant (H1975 H1993) NSCLC were treated with a panel or MET inhibitors, then for changes signaling, glycolytic cascade, function. Silencing key enzymes was performed siRNAs....
PURPOSE Since we have previously shown that the efflux rate of technetium 99m (99mTc) sestamibi, a transport substrate P-glycoprotein (Pgp), is directly correlated with Pgp levels in untreated breast carcinoma, tested whether tumor clearance 9mTc-sestamibi may be predictive therapeutic response to neoadjuvant chemotherapy patients locally advanced cancer. PATIENTS AND METHODS Thirty-nine stage III disease, median diameter 5.8 cm (range, 3 10) were enrolled onto this prospective clinical...
Although the anti-EGF receptor (EGFR) monoclonal antibody cetuximab is an effective strategy in colorectal cancer therapy, its clinical use limited by intrinsic or acquired resistance. Alterations "sphingolipid rheostat"-the balance between proapoptotic molecule ceramide and mitogenic factor sphingosine-1-phosphate (S1P)-due to sphingosine kinase 1 (SphK1) overactivation have been involved resistance anticancer-targeted agents. Moreover, cross-talks SphK1 EGFR-dependent signaling pathways...
The aim of our study was to predict the occurrence distant metastases in non-small-cell lung cancer (NSCLC) patients using machine learning methods and texture analysis 18F-labeled 2-deoxy-d-glucose Positron Emission Tomography/Computed Tomography {[18F]FDG PET/CT} images. In this retrospective single-center study, we evaluated 79 with advanced NSCLC who had undergone [18F]FDG PET/CT scan at diagnosis before any therapy. Patients were divided into two independent training (n = 44) final...
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play relevant role thrombus formation and metastatic dissemination of cancer cells. Here we screened different cell lines endogenously expressing variety integrins for ability bind NETs. To this end, used NETs isolated from neutrophil-like cells substrate adhesion assays HT1080, U-87 MG, H1975, DU 145, PC-3 A-431 Levels α5, αIIb, αv, β1, β3 β5 chains were determined by western blot analysis all...
Neutrophil extracellular traps (NETs), originally recognized as a host defense mechanism, were reported to promote thrombosis and metastatic dissemination of cancer cells. Here we tested the role integrins α5β1 ανβ3 in adhesion cells NETs. Neutrophil-like stimulated with calcium ionophore (A23187) used stable source cell-free NETs-enriched suspensions. Using NETs an substrate, two human K562 cell lines, differentially expressing integrins, subjected assays presence or absence DNAse 1,...
SUMMARY A number of trials have demonstrated that IFN-α is effective in chronic hepatitis C virus infection. It known, however, a patients experience, after an initial response to IFN, disease reactivation or relapse (also called ‘breakthrough’) while IFN therapy still ongoing. Since clinical conditions significant correlation between development antibodies and failure has been established, we addressed the possibility may take part occurring during recombinant (rIFN-α) therapy. The...