A5002797400- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Nuclear Structure and Function
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Management of metastatic bone disease
- Cancer Cells and Metastasis
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Spine and Intervertebral Disc Pathology
- Protein Degradation and Inhibitors
- Radiomics and Machine Learning in Medical Imaging
- Endometriosis Research and Treatment
- Vascular Tumors and Angiosarcomas
Union Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
Yangzhou University
2025
Hainan Medical University
2024
Hainan General Hospital
2024
Third Affiliated Hospital of Southern Medical University
2014-2023
Southern Medical University
2012-2020
Southwest Minzu University
2018
Huawei Technologies (China)
2012
Objective: To evaluate the safety and efficacy of mitoxantrone liposome (MIT-LIP) combined chemotherapy in treating mixed phenotype acute leukemia (MPAL) . Methods: December 2021 to November 2024, MPAL patients who underwent MAED (MIT-LIP + cytarabine etoposide dexamethasone) regimen were retrospectively analyzed. Data on clinical characteristics, adverse reactions, therapeutic outcomes, long-term prognoses collected. Results: A total 7 received admitted. Among them, two initially diagnosed...
Pseudorabies (PR) remains one of the most important swine diseases in China. Live attenuated vaccines have been widely deployed and proven highly effective controlling PR field. However, recent concerns regarding evolution recombination events involving pseudorabies virus (PRV) vaccine strains raised substantial attention. In present study, a novel recombinant PRV strain named HN2201 was isolated from stillbirth case Henan province 2022. To assess genetic evolutionary features, major...
Circulating tumor cells (CTCs) have been identified as a prognostic biomarker of tumors such breast cancer and nasopharyngeal carcinoma, because they are obtained through simple noninvasive blood draw or liquid biopsy, but its clinical significance in osteosarcoma is still unclear. In this study, we analyzed the relationship between CTCs clinicopathological features discussed whether could be used for metastasis osteosarcoma.We enrolled 50 patients with Enneking Stage IIB III detected 5 ml...
Hypoxia is associated with poor response to treatment in various cancers. inducible factor 1 (HIF-1) a major transcription that mediates adaptation of cancer cells hypoxic environment and regulates many genes are involved key cellular functions, including cell immortalization, stem maintenance, autocrine growth/survival, angiogenesis, invasion/metastasis, resistance chemotherapy. HIF-1α has been considered as an attractive therapeutic target for treatment, but there limited success this...
Abstract Geranylgeranylacetone (GGA), an inducer of heat shock proteins, exerts anticancer activity in some tumours. However, the effect GGA on human osteosarcoma (OS) has not been reported. This work is designed to evaluate proliferation and apoptosis OS cells explore underlying mechanisms. It was found that markedly inhibited induced U‐2 a dose‐dependent manner also up‐regulated expression protein 70 (Hsp70). The degradation ubiquitination arginine N‐methyltransferase 1 (PRMT1) were...
Karyopherin α (KPNA) proteins are involved in nucleocytoplasmic trafficking and critical for protein subcellular localization. Recent studies have suggested that KPNA abnormally expressed various solid tumors. The objective of this study was to investigate the expression KPNA1 KPNA2 cervical cancer tissue with different histologic grades cell lines, as well effects level on Hela proliferation. We collected medical data 106 patients investigated by immunohistochemistry western blot. results...
Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles transforming growth factor- (TGF-) α interaction between and BMSCs BM. Clinical cases with (BMBC), without (Non-BM-BC), benign fibroadenoma (Benign) were enlisted a retrospective study. TGF- was found obviously overexpressed BM lesion BMBC compared primary both...
Glycine decarboxylase (GLDC) is one of the core enzymes for glycine metabolism, and its biological roles in prostate cancer (PCa) are unclear. First, we found that GLDC plays a central role glycolysis 540 TCGA PCa patients. Subsequently, metabolomic microarray showed enhanced aerobic cells, enzyme activity glucose uptake, lactate production dehydrogenase (LDH) cells. Next, was highly expressed PCa, directly regulated by hypoxia-inducible factor (HIF1-α) downstream LDHA expression. In...
Abstract Background Karyopherin α2 (KPNA2), a member of the karyopherin α family, has been studied in several cancers but not yet substantially investigated malignant bone tumors. The purpose current study was to evaluate KPNA2 expression level and its utility as novel diagnostic biomarker osteosarcomas tumor mimics, such chondrosarcomas Ewing sarcomas (ESs). Method We protein by immunohistochemistry on paraffin-embedded surgical specimens from 223 patients with benign tumors, including 81...
<b><i>Objective:</i></b> To investigate the optimal age for baseline serum prostate-specific antigen (PSA) test and repeat screening its economic burden in a single center China. <b><i>Materials Methods:</i></b> 35,533 men with PSA were retrospectively enrolled this study. Follow-ups conducted 1,586 &#x3e;4 ng/mL, receiver-operating characteristic (ROC) curves employed to cutoffs. <b><i>Results:</i></b> ROC analysis...
The aim of our study was to the relationship blastospores and pseudohyphae in Papanicolaou (Pap) smears Nugent scores for bacterial vaginosis (BV).A total 471 Pap with Candida albicans were reviewed. presence established. restained Gram stain method evaluate flora according scoring system.Of smears, observed 62.8% (296/471) 37.2% (175/471) displayed symptoms 4.4% (13/296) 43.4% (76/175), respectively. A significant difference found between these 2 groups (p < 0.0001). positive BV score (≥ 7)...
Inflammation is implicated in both hepatic cirrhosis development and hepatocellular carcinogenesis, treatment with long-acting glucocorticoid dexamethasone prevented liver carcinogenesis mice. However, it unclear whether glucocorticoids have anti-inflammatory effect on carcinoma (HCC) if short-acting (with fewer adverse effects) inhibit paraneoplastic inflammation HCC progression.To investigate different types of agents attenuate progression, the current study compared effects treatments...
Insulin‑like growth factor II mRNA‑binding protein 3 (IMP3) is an oncofetal upregulated in tumor cells during carcinogenesis. The aim of the present study was to investigate expression status IMP3 colorectal cancer (CRC) tissues and its clinical significance. Immunostaining performed 130 CRC samples, association with clinicopathological characteristics assessed 58 patients were selected for survival analysis. To best our knowledge, describes first time stromal components CRC. Stromal...
To evaluate the diagnostic value and compare morphological features of cell block sections high-grade squamous intraepithelial lesions (HSIL) carcinomas (SCC).A total 135 blocks were prepared from residual Liqui-PREP samples. Of these, 43 biopsy-confirmed cases (24 HSIL 19 SCC) reviewed. Morphological determined included clusters, epithelial-stromal interface, stromal invasion tumor necrosis.Ninety-three percent (40/43) diagnoses consistent with histological diagnoses, which was better than...