A5100399707- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Sexuality, Behavior, and Technology
- Eicosanoids and Hypertension Pharmacology
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Calcium signaling and nucleotide metabolism
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Cancer-related Molecular Pathways
- Lysosomal Storage Disorders Research
First Hospital of Shanxi Medical University
2015-2025
Shanxi Medical University
2015-2025
Third Affiliated Hospital of Southern Medical University
2012-2025
First Hospital of Shijiazhuang
2025
Kunming Medical University
2014-2023
Jilin University
2023
First Hospital of Jilin University
2023
Second Affiliated Hospital of Kunming Medical College
2014-2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Massive loss of cardiac myocytes after myocardial infarction (MI) is a common cause heart failure. The present study was designed to investigate the improvement function in MI rats embryonic stem (ES) cell transplantation. induced by ligation left anterior descending coronary artery. Cultured ES cells used for transplantation were transfected with marker green fluorescent protein (GFP). Animals treated group received intramyocardial injection injured myocardium. Compared control injected an...
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and fourth lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little mutational processes responsible. To identify genome-wide signatures, performed either whole-genome sequencing (WGS) or whole-exome (WES) on 104 ESCC individuals combined our data those 88 previously reported samples. An APOBEC-mediated signature 47% 192 tumors suggests...
Centromere Protein F (CENPF) associates with the centromere-kinetochore complex and influences cell proliferation metastasis in several cancers. The role of CENPF breast cancer (BC) bone remains unclear.Using ONCOMINE database, we compared expression normal tissues. Findings were confirmed 60 BC patients through immunohistochemical (IHC) staining. Microarray data from GEO Kaplan-Meier plots used analyze overall survival (OS) relapse free (RFS). Using databases, primary lesions, lung lesions...
The prognosis for hepatocellular carcinoma (HCC) remains dismal in terms of overall survival (OS), and its molecular pathogenesis has not been completely defined. Here, we report that expression deubiquitylase ubiquitin‐specific protease 7 (USP7) is higher human HCC tissues than matched peritumoral tissues. Ectopic USP7 promotes growth cells vivo vitro . Mechanistically, overexpression fosters cell by forming a complex with stabilizing thyroid hormone receptor‐interacting protein 12...
Angiogenesis is one of the important factors related to tumorigenesis, invasion, and metastasis. Cancer-secreted exosomes are essential mediators intercellular cross-talk participate in angiogenesis Unveiling mechanism an way develop anti-angiogenesis therapeutic strategies against cancer progression. miR-1825 expression relationship with microvascular density were validated colorectal (CRC) by situ hybridization (ISH) staining immunohistochemistry (IHC). Sequential differential...
Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic inflammation response index (SIRI), and immune (SII) for early recurrence after liver resection in patients with hepatitis B-related hepatocellular carcinoma. Methods A retrospective study was conducted on 162 who underwent carcinoma (HCC) between January 2013 April 2016. The Youden utilized to calculate optimal cut-off value. Pearson Chi-square test...
Hypoxia-inducible factor 1 (HIF-1) is a transcription that controls vascular responses to hypoxia and ischemia. In this study, mice were heterozygous (HET) for null allele at the locus encoding HIF-1α subunit (HET mice) their wild-type (WT) littermates subjected thermal injury involving 10% of body surface area. protein levels increased in burn wounds WT but not HET on day 2. The serum stromal-derived 1α, which binds CXCR4, 2 mice. Circulating angiogenic cells also included CXCR4+Sca1+...
Endothelial cells are known to contribute kidney fibrosis via endothelial-mesenchymal transition (EndoMT). Matrix metalloproteinase 9 (MMP-9) is be profibrotic. However, whether MMP-9 contributes EndoMT unknown.Primary mouse renal peritubular endothelial (MRPECs) were isolated and treated by recombinant human transforming growth factor beta 1 (rhTGF-β1) with or without inhibitor (rhMMP-9) alone. Kidney was induced unilateral ureteral obstruction (UUO) in knockout (KO) wide-type (WT) control...
Tumor-associated macrophage (TAM) is a major component of tumor microenvironment (TME) and plays critical role in the progression cancer metastasis. However, TAM-mediated regulation gallbladder (GBC) has not been fully characterized. Here, we found that exosomes derived from GBC cell polarized to M2 phenotype, which then facilitated invasion migration cells. We discovered leptin was enriched cell-derived exosomes. Exosomal levels promoted GBC-SD The inhibition only attenuated polarization...
Colon adenocarcinoma (COAD) is a serious public health problem, the third most common cancer and second deadly in world. About 9.4% of cancer-related deaths 2020 were due to COAD. Anoikis specialized form programmed cell death that plays an important role tumor invasion metastasis. The presence anti-anoikis factors associated with aggressiveness drug resistance. Various bioinformatic methods, such as differential expression analysis, functional annotation machine learning, used this study....
Background and Aims An immune imbalance in the cytokine profile exerts a profound influence on progression of hepatitis B virus (HBV) infections hepatocellular carcinoma (HCC). The present study evaluated status T helper (Th) 17 Th1 cells patients with HBV-related non-HBV-related HCC. Methods We randomly enrolled 150 Blood samples tissue were obtained. distributions phenotypic features Th17 determined by flow cytometry and/or immunohistochemistry. Results Compared to corresponding non-tumor...
Abstract Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as negative regulator T cells and then promotes progression. However, its expression role intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, ICC peritumoral tissues was determined at the level mRNA protein, bioactivity studied after modification expression. Then, mechanism related to progression induced by explored. Finally, clinical significance patients further analyzed....
The gut microbiome has been recognized as a significant contributor to primary hepatocellular carcinoma (HCC), with mounting evidence indicating associations between bacterial components and cancers of the digestive system.Here, characterize signature in patients HCC assess diagnostic potential taxa for HCC, 21 healthy first-degree relatives (control group) were enrolled this study. Bacterial DNA fecal samples was quantified by 16S rRNA gene sequencing. We found that 743 operational...
Highlights•miR-1825 is upregulated in CRC and associated with progression•circTBC1D22A functions as an efficient miR-1825 sponge cells•ATG14 functional target of cells•circTBC1D22A regulates autophagy via miR-1825/ATG14 axisSummaryDistant metastasis the main cause death patients colorectal cancer (CRC). A better understanding mechanisms can greatly improve outcome CRC. Accumulating evidence suggests that circRNA plays pivotal roles progression metastasis, especially acting a miRNA to...
The immunoproteasome is a multicatalytic protease complex in all eukaryotic cells, which plays key role regulating essential cellular processes. However, the of subunit β2i regulation cardiac fibrosis and inflammation deoxycorticosterone-acetate (DOCA)/salt mice remains unknown. Wild-type (WT) knockout (KO) were subjected to uninephrectomy DOCA/salt treatment for 21 days. Blood pressure was measured by tail-cuff system. Cardiac function remodeling examined echocardiography, hematoxylin-eosin...
Colorectal cancer liver metastases (CRLM) are the primary cause of mortality in colorectal (CRC) patients, highlighting importance understanding underlying mechanisms. The tumor microenvironment (TME) and its interaction with cells play a crucial role CRLM progression. Notably, stability peak levels tumor-derived exosomal miRNAs facilitate intercellular communication TME. Hepatic stellate (HSCs), key mesenchymal cells, constitute about 33% liver's nonsolid cell population exhibit plasticity....
Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is a key contributor to cancer-related deaths globally. However, HCC diagnosis solely based on blood biochemical markers lacks both sensitivity and specificity. To investigate alterations fecal metabolome intestinal bacteria reveal correlations among differential metabolites, distinct bacteria, serum indicators. uncover potentially effective therapeutic targets for HCC, we utilized non-targeted liquid...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence mortality rates are increasing worldwide. Mortalin a highly conserved chaperone protein involved in multiple pathological physiological processes, including anti-apoptosis, carcinogenesis metastasis. The Bcl-2 family proteins can be divided into pro-survival pro-apoptotic members, B-cell lymphoma 2 (Bcl-2) Bcl-2-like 4 (Bax). aim the present study was to investigate association between mortalin, Bax, as...
The aim of the present study was to investigate expression transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-<TEX>${\alpha}$</TEX> in tumor tissue patients with invasive ductal carcinoma(IDC); addition, we examined correlations between these markers. Two hundred sixteen IDC patients, who were not previously been treated chemo- or radiotherapy, included study. All tumors grade I-III. Expression molecular markers determined by immunohistochemical analysis on paraffin-embedded...
TRIP13 is a member of the large superfamily AAA + ATPase proteins and associated with variety activities. Emerging evidence has shown that may serve as an oncogene. However, function in breast cancer (BC) not yet been elucidated. Here, bioinformatic tools laboratory experiments were combined to analyse expression patterns, prognostic value functional network BC. Multiple databases immunohistochemistry (IHC) indicated higher BC tissue compared normal tissue. was highly expressed lung...
The 14-3-3 proteins are highly conserved molecules that involved in many vital biologic processes and associated with the progression of cancer. role 14-3-3ζ, a dimeric isoform 14-3-3, intrahepatic cholangiocarcinoma (ICC) was investigated this study. expression 14-3-3ζ tumour samples from patients ICC examined by Western blot immunohistochemistry, correlation between its various clinicopathological features determined. Then, capacity for invasion, migration proliferation as well...