A5101772756- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- GDF15 and Related Biomarkers
- Musculoskeletal pain and rehabilitation
- Salivary Gland Disorders and Functions
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Oral microbiology and periodontitis research
- Osteoarthritis Treatment and Mechanisms
- Osteomyelitis and Bone Disorders Research
- Medicinal Plant Pharmacodynamics Research
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Biochemical effects in animals
- Liver Disease and Transplantation
- Oral Health Pathology and Treatment
- Hydrogen's biological and therapeutic effects
- Inflammasome and immune disorders
- Ziziphus Jujuba Studies and Applications
- Natural Compounds in Disease Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Cardiac Fibrosis and Remodeling
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Shanxi Medical University
2011-2023
Changzhi Medical College
2011-2023
Beijing University of Chinese Medicine
2020-2023
Weatherford College
2022
University of Calgary
2022
Shanxi Academy of Medical Sciences
2022
Jiangsu Food and Pharmaceutical Science College
2021
Affiliated Hospital of Hangzhou Normal University
2020
The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related 2 (Nrf2) is a redox-sensitive master switch that regulates expression antioxidant protective enzymes. This study investigated effects 2% H2 on intestinal injuries underlying mechanisms mouse model severe Male Nrf2 knockout mice (Nrf2-KO) wild-type (WT)...
Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic inflammation response index (SIRI), and immune (SII) for early recurrence after liver resection in patients with hepatitis B-related hepatocellular carcinoma. Methods A retrospective study was conducted on 162 who underwent carcinoma (HCC) between January 2013 April 2016. The Youden utilized to calculate optimal cut-off value. Pearson Chi-square test...
To examine the therapeutic effects of tocilizumab, an antibody against interleukin-6 receptor, on experimental severe acute pancreatitis and associated lung injury. The optimal dose tocilizumab activation inflammatory signaling were also investigated.Randomized experiment.Research laboratory at a university hospital.Experimental in rats.Severe was induced by retrograde injection sodium taurocholate (50 mg/kg) into biliopancreatic duct. In dose-study, rats administered with different doses...
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Inhaled nitric oxide (NO) has been reported to ameliorate ALI. However, reactive nitrogen species produced by NO can injury. Because hydrogen gas (H2) eliminate peroxynitrite, it expected reduce the adverse effects NO. Moreover, we have found that H2 inhalation attenuate Therefore, hypothesized combination therapy with might afford more potent therapeutic strategies for In present study,...
Alzheimer’s disease (AD) is the most common cause of dementia, and effective therapeutics are lacking. Colivelin (CLN), a novel, strong humanin derivative, in vitro preventing cell death induced by AD-causative genes amyloid-β protein (Aβ) even at low concentration. We recently demonstrated that intrahippocampal injection CLN prevents Aβ 25–35 -induced deficits spatial memory synaptic plasticity normal rats. Here, we further observed effects chronically intranasally (i.n.) administered on...
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity. However, it is still unclear whether Rattin can Aβ-induced deficits cognition and synaptic plasticity rats. In present study, we observed effects Aβ31-35 on spatial reference memory vivo hippocampal Long-term potentiation rats by using Morris water maze test field potential recording. Furthermore, probable molecular mechanism underlying...
To assess the clinical effect of astragalus polysaccharide in preventing cardiotoxicity induced by chemotherapy epirubicin. Two hundred forty-eight patients with breast cancer or malignant lymphoma were randomly divided into experimental group (EG) (n = 124) and control (CG) 124). The EG received regimen containing anthracycline epirubicin injection, while CG only We detected myocardial function (cardiac troponin I [cTnI], creatine kinase isoenzyme [CK-MB], left ventricular ejection fraction...
ABSTRACT Amyloid β protein (Aβ) plays a critical role in pathogenesis of Alzheimer's disease (AD). Our previous studies indicated that the sequence 31–35 Aβ molecule is an effective active center responsible for neurotoxicity vivo and vitro . In present study, we prepared novel antibody specifically targeting amyloid protein, investigated neuroprotection anti‐Aβ against 1–42 ‐induced impairments neuronal viability, spatial memory, hippocampal synaptic plasticity rats. The results showed...
Acute lung injury is one of the critical complications acute pancreatitis (AP). Tumor necrosis factor-associated factor 6 (TRAF6) a key adaptor that regulates various inflammatory signaling pathways, including those mediated by Toll-like receptors (TLRs). This study was performed to investigate potential role TRAF6 in pathogenesis AP and pancreatitis-associated using mouse model caerulein-induced (CAP). CAP induced intraperitoneal injection caerulein hourly for 7 times (50μg/kg), control...
The effects of the periodontal intervention on rats with type-II diabetes mellitus (T2DM) and chronic periodontitis (CP) were explored through observing changes in carotid artery pathology interleukin-6 (IL-6) levels. randomly divided into 5 groups, i.e. group A (the normal control group), B T2DM C CP D + E group). Blood samples collected from angular veins respectively at following time nodes: 1 week before (T1), after (T2), 3 weeks (T3), (T4), 7 (T5); IL-6 concentrations determined by...
Corrosion of duplex stainless steels (DSS) usually initiates at a specific phase, causing preferential phase-dissolution in aqueous environments. Although the scanning Kelvin probe force microscopy (SKPFM) can characterise phase-corrosion micro- or even nanoscale, conventional data-processing methods are insufficient to analyse massive data derive mechanistic information, and sometimes, cause misunderstanding corrosion evolution. Here we utilised root mean square, power spectral density...
Objective: The study of ossification posterior longitudinal ligament (OPLL) is attracting increasing attention. This aims to investigate the global status and trends in this field. Methods: Web Science-Science Citation Index Expanded searched number publications published by OPLL from January 1, 1900 March 2023. Source data were studied indexed using bibliometric methods. For visualization studies, use VOSviewer version 1.6.19 software for co-authorship, co-occurrence analysis, bibliographic...