A5024940456- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Cutaneous Melanoma Detection and Management
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
- Eosinophilic Esophagitis
- Lung Cancer Treatments and Mutations
- Reproductive System and Pregnancy
- Reproductive tract infections research
Tongji University
2011-2025
Shanghai Pulmonary Hospital
2011-2025
University of Arizona
2015-2024
University of Arizona Cancer Center
2014-2024
Shanxi Medical University
2024
Ministry of Public Security of the People's Republic of China
2024
Third Affiliated Hospital of Southern Medical University
2018-2024
Guangxi Medical University
2024
Hebei Academy of Agriculture and Forestry Sciences
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2021-2024
Summary Background: Recent reports suggest that patients with non‐erosive reflux disease (NERD) treated anti‐reflux medications show lower symptom improvement rates than erosive oesophagitis the same medications. Aim: To determine acid and patterns of NERD in comparison those Barrett's oesophagus, to identify different subgroups. Methods: One hundred forty‐nine consecutive seen for classic heartburn symptoms were evaluated study. Oesophageal mucosal injury was assessed by upper endoscopy...
While high-risk human papillomavirus (HPV) infection is a well-established risk factor for cervical cancer, there are likely other factors within the local microenvironment that contribute to carcinogenesis. Here we investigated relationships between HPV, vaginal pH, microbiota (VMB) composition, level of genital immune mediators and severity neoplasm. We enrolled women with low- high-grade dysplasia (LGD, HGD), invasive carcinoma (ICC), healthy controls. HPV16, HPV45, HPV58, HPV31 were most...
Persistent human papillomavirus (HPV) infection is the vital factor driving cervical carcinogenesis; however, other features of local cervicovaginal microenvironment (CVM) may play a critical role in development precancerous dysplasia and progression to invasive carcinoma (ICC). Here we investigated relationships between locally secreted cancer biomarkers CVM better understand complex interplay host, virus vaginal microbiota (VMB). We enrolled women with ICC, high- low-grade squamous...
Airway epithelial injury in response to allergens such as toluene diisocyanate (TDI) leads persistent airway inflammation. Pyroptosis is recognized a strong proinflammatory cell death process. However, the role of pyroptosis bronchial and inflammation TDI-induced asthma remains unknown. In this study, cytotoxic effect TDI on 16HBE cells (a human line) was detected. Then experimental mouse model established for vivo study. Here we found that induced cells, evidenced by enhanced expressions...
Background: To identify the optimal sequencing and timing of immunotherapy (IT) stereotactic radiosurgery (SRS) for melanoma brain metastases (MBMs).Methods: The elapsed days between IT SRS were correlated with local control (LC), regional (RBC), time to CNS progression (TTPCNS), overall survival (OS), radiation necrosis (RN). Logistic regression Cox proportional models used statistical analysis.Results: Twenty-five patients 58 MBMs underwent IT. Median follow-up was 22.7 mo (3.1–77.9 mo). A...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB unaccounted for additional susceptibility loci most likely exist. We perform multistage genome-wide association study on 2949 pulmonary patients 5090 healthy controls (833 cases 1220 were genotyped) from Han Chinese population....
We determine the impact of nerve sparing techniques on quality life after radical retropubic prostatectomy for prostate cancer.The RAND/UCLA Prostate Cancer Index and several questions about surgical outcomes, including sexual function, were sent to 170 consecutive patients at least 1 year prostatectomy. Statistical analysis was performed data entire group as well subgroups nonnerve surgery.Nonnerve surgery in 83 129 responders (nonnerve group) remaining 46 treated with unilateral (nerve...
Clopidogrel decreases recurrent ischemic events and improves intracoronary stent patency. There are scarce data on the effect of short-term long-term clopidogrel symptom recurrence adverse cardiac following off-pump coronary artery bypass graft surgery (OPCAB).Postoperative antiplatelet medication use was prospectively evaluated in 591 OPCAB patients. administered for 30 days 186 patients 139 received (mean 33.6+/-12.0 months) addition to aspirin. Follow-up 37.7+/-13.4 months. Symptom...
Background and Objectives This study was performed to investigate recent trends factors associated with immediate breast reconstruction (IBR) using a large population-based registry. We hypothesized that rates of IBR have increased since passage the Women's Health Cancer Rights Act 1998. Methods The SEER (surveillance, epidemiology end results) database used evaluate Stage I–III cancer (BC) patients who underwent total mastectomy from 1998 2008. Univariate multivariate analyses were...
Lung cancer is one of the leading causes cancer-related mortality, and responds badly to existing treatment. Thus, it urgent need identify novel diagnostic markers therapeutic targets. Increasing evidences have indicated that long non-coding RNAs (lncRNAs) play an important role in initiation progression lung cancer. However, lncRNA Taurine upregulated 1 (TUG1) adenocarcinoma (LAD) not well known. In this study, we determined value TUG1 LAD patients, further uncovered underlying functional...
BACKGROUNDGastric cancer is a prevalent malignant with high incidence and significantly affects the health of modern people globally.Cisplatin (DDP) one most common effective chemotherapies for patients gastric cancer, but DDP resistance remains severe clinical challenge. AIMTo explore function M2 polarized macrophages-derived exosomal microRNA (miR)-588 in modulation cells. METHODSM2 macrophages were isolated identified by specific markers using flow cytometry analysis.The exosomes from...
Summary Background : Empirical trial with high‐dose omeprazole has been shown to be a sensitive tool for diagnosing patients gastro‐oesophageal reflux disease‐related non‐cardiac chest pain. Aim To determine the clinical value of an empirical lansoprazole in detecting Methods Patients who were referred by cardiologist after comprehensive evaluation, at least three episodes per week unexplained pain as predominant symptom, enrolled into study. Oesophageal mucosal disease was determined upper...
Abstract Purpose: Barrett’s esophagus (BE) is a common premalignant lesion of the distal part that arises as consequence chronic duodenogastroesophageal reflux. Interleukin (IL)-6 pleiotropic cytokine regulates immune defense mechanisms and hematopoiesis. In addition, IL-6 may also be involved in malignant transformation tumor progression. has been shown to inhibit apoptosis. The major aim this study was evaluate expression BE at protein mRNA levels. we tested whether proteins are associated...
Abstract Purpose: This phase II trial evaluated bevacizumab plus erlotinib in platinum-resistant ovarian cancer; exploratory biomarker analyses, including that of tumor vascular endothelial growth factor A (VEGF-A), were also done. Experimental Design: Forty heavily pretreated patients received (150 mg/d orally) and (10 mg/kg i.v.) every 2 weeks until disease progression. Primary end points objective response rate duration; secondary included progression-free survival (PFS), toxicity,...
MicroRNAs (miRNAs) may function as tumor suppressor or onco‑miRNAs and have critical roles in the pathogenesis of gastric cancer (GC). The exact mechanism miRNA (miR)‑320a GC remains to be elucidated. present study performed gain‑ loss‑of‑function analyses by transfecting cells with mimics inhibitors subsequently performing colony formation, proliferation cisplatin‑sensitivity assays. Additionally, vivo xenograft models were also performed. Bioinformatics algorithms, luciferase reporter...
Exposure of humans to organophosphate flame retardants (OPFRs) and the consequent health risk have increased owing latter's widespread application. Although triphenyl phosphate (TPP), an OPFR, is a potential chemical determinant liver function damage, its effects on kidney in mice under high fructose/fat (HFF) diet are still unclear. In this study, C57BL/6J were fed HFF generate obesity model exposed low dose (0.01 mg/kg/day; TPP-L) (1 TPP-H) TPP for 12 weeks. Results showed that TPP-L TPP-H...
Immunotherapy based on immune checkpoint inhibitors (ICIs) have demonstrated remarkable survival benefits and gained regulatory approval in non-small cell lung cancer (NSCLC) patients without an actionable driver mutation, but currently there is no well-established standard for how to screen the most suitable population ICIs treatment. Here, we conducted a comprehensive analysis of somatic mutation landscape adenocarcinoma (LUAD) samples. After stepwise screening high-frequency mutated...
New economic, rapid, and efficient diagnostic methods are desirable for the control of tuberculosis. This study aimed to evaluate performance a dual-gene qPCR melting curve assay (DGPMC) in detecting tuberculosis among patients with suspected pulmonary The DGPMC based on rpoB IS6110 gene sequences has been established detection Mycobacterium A prospective was conducted adult from June 2021 September 2023 at Shanghai Pulmonary Hospital, China. All received symptom assessment, high-resolution...
The distribution of alpha6/alpha3 integrin in adhesion complexes at the basal membrane human normal and cancer prostate glands was analyzed 135 biopsies from 61 patients. levels polarized expression tumor were determined by quantitative immunohistochemistry. compared with Gleason sum score, pathological stage, preoperative serum prostate-specific antigen (PSA). associations assessed statistical methods. Eighty percent tumors expressed alpha6 or alpha3 20% integrin-negative. but not PSA,...
We evaluated the efficacy of cold knife urethrotomy for anastomotic stricture after radical retropubic prostatectomy.We contacted all patients who underwent a symptomatic from May 1, 1992 through January 2000 at our institution. A control group prostatectomy but did not complain decreased urine stream was similarly evaluated. Maximum urinary flow rate, post-void residual volume, American Urological Association (AUA) symptom index benign prostatic hyperplasia, and continence status with...