A5103169839- HIV Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Axon Guidance and Neuronal Signaling
- Gastric Cancer Management and Outcomes
- Tumors and Oncological Cases
- PI3K/AKT/mTOR signaling in cancer
- Oral and Maxillofacial Pathology
- Reproductive System and Pregnancy
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Quinazolinone synthesis and applications
- Peripheral Nerve Disorders
- Teratomas and Epidermoid Cysts
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
Tata Main Hospital
2023-2024
Tata Memorial Hospital
2023
National Institute of Technology Jamshedpur
2022
Beth Israel Deaconess Medical Center
2011-2021
Harvard University
2009-2021
University of Arizona
2003-2012
Onconova Therapeutics (United States)
2012
University of Saint Mary
2012
Georgetown University
2010
Georgetown University Medical Center
2010
Cannabidiol (CBD), a major nonpsychoactive constituent of cannabis, is considered an antineoplastic agent on the basis its in vitro and vivo activity against tumor cells. However, exact molecular mechanism through which CBD mediates this yet to be elucidated. Here, we have shown CBD-induced cell death breast cancer cells, independent cannabinoid vallinoid receptor activation. Electron microscopy revealed morphologies consistent with coexistence autophagy apoptosis. Western blot analysis...
Barrett's oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to ADCA.To test hypothesis bile acids and gastric acid, two components refluxate, can induce stress DNA damage.Oxidative was evaluated by staining tissues different degrees dysplasia 8-hydroxy-deoxyguanosine (8-OH-dG) antibody. The levels 8-OH-dG were also ex vivo in incubated 10 min control...
Abstract Non–small cell lung cancer (NSCLC) is the leading cause of deaths worldwide; however, only limited therapeutic treatments are available. Hence, we investigated role cannabinoid receptors, CB1 and CB2, as novel targets against NSCLC. We observed expression (24%) CB2 (55%) in NSCLC patients. Furthermore, have shown that treatment lines (A549 SW-1573) with CB1/CB2- CB2-specific agonists Win55,212-2 JWH-015, respectively, significantly attenuated random well growth factor-directed vitro...
Slit, which mediates its function by binding to the Roundabout (Robo) receptor, has been shown regulate neuronal and CXCR4-mediated leukocyte migration. Slit-2 was be frequently inactivated in lung breast cancers because of hypermethylation promoter region. Furthermore, CXCR4/CXCL12 axis reported recently actively involved cancer metastasis target organs such as lymph nodes, lung, bone. In this study, we sought characterize effect Slit (=Slit-2) on CXCL12/CXCR4-mediated metastatic properties...
Abstract Slit, which mediates its function by binding to the Roundabout (Robo) receptor, has been shown regulate neuronal, dendritic, and leukocyte migration. However, molecular mechanism Slit/Robo complex inhibits migration of cells is not well defined. Here, we showedthat Slit-2 can inhibit CXCL12-induced chemotaxis transendothelial T monocytes. We observed that CXCR4 associates with Robo-1 treatment enhances this association receptor. a single-pass transmembrane receptor whose...
Abstract Exosomes are membrane enclosed nano-sized vesicles actively released into the extracellular milieu that can harbor genomic, proteomic and lipid cargos. Functionally, they shown to regulate cell-cell communication transmission of pathogens. Though studies have implicated a role for exosomes in HIV-1 pathogenesis, their mechanisms not well defined. Here, we characterized derived from uninfected or infected T-cells DCs. We demonstrate substantial differences morphological, molecular...
Abstract Background.—We have previously studied the immunoreactivity of 3 novel smooth muscle–specific proteins, α-smooth muscle actin, myosin heavy chains, and calponin, to assess myoepithelial differentiation in pleomorphic adenomas. Objective.—To further expand our knowledge other benign malignant salivary gland tumors. Design.—Formalin-fixed paraffin sections 135 tumors with associated normal glands were stained monoclonal antibodies using avidin-biotin complex immunoperoxidase method...
Salivary duct carcinoma is a relatively uncommon aggressive neoplasm, typically found in the parotid glands of older men. The histologic appearance that an situ and invasive high-grade adenocarcinoma, it closely resembles ductal breast. Several variants latter are very well known, but only papillary, sarcomatoid, low-grade subtypes have so far been reported salivary carcinoma. This study describes clinicopathologic immunohistochemical findings four examples additional previously undescribed...
Abstract Background.—We have previously studied the immunoreactivity of 3 novel smooth muscle–specific proteins, α-smooth muscle actin, myosin heavy chains, and calponin, to assess my...
Abstract Objectives: The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear. Our previous studies showed that BE tissues secrete interleukin-6 (IL-6) and express proteins associated with IL-6 signaling, including receptor, activated signal transducer activators transcription 3 (STAT3), antiapoptotic Bcl-xL Mcl-1. Here, we test hypothesis bile acids gastric acids, two components refluxate gastresophageal reflux disease, activate IL-6/STAT3 pathway....
Abstract Purpose: Barrett’s esophagus (BE) is a common premalignant lesion of the distal part that arises as consequence chronic duodenogastroesophageal reflux. Interleukin (IL)-6 pleiotropic cytokine regulates immune defense mechanisms and hematopoiesis. In addition, IL-6 may also be involved in malignant transformation tumor progression. has been shown to inhibit apoptosis. The major aim this study was evaluate expression BE at protein mRNA levels. we tested whether proteins are associated...
Objective To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation. Design Immunohistochemical evaluation 25 basal cell and canalicular adenomas. Setting Archival pathology material from the files Henry Ford Hospital, Detroit, Mich, University California at San Francisco. Results All adenoma variants exhibit some degree participation with periductal,...
Cancers often arise within an area of cells (e.g. epithelial patch) that is predisposed to the development cancer, i.e. a "field cancerization" or defect." Sporadic colon cancer characterized by elevated mutation rate and genomic instability. If field defect were deficient in DNA repair, damages would tend escape repair give rise carcinogenic mutations.To determine whether reduced expression proteins Pms2, Ercc1 Xpf (pairing partner Ercc1) are early steps progression cancer.Tissue biopsies...
Abstract Methamphetamine (Meth) exacerbates HIV-1 pathobiology by increasing virus transmission and replication accelerating clinical progression to AIDS. Meth has been shown alter the expression of co-receptors impair intrinsic resistance mechanisms immune cells. However, exact molecular involved in augmenting T-cells are still not yet clear. Here, we demonstrate that pretreatment with CD4 + enhanced replication. We observed upregulation T-cell activation markers miR-34c-5p miR-155 these...
Abstract Objective.—To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation. Design.—Immunohistochemical evaluation 25 basal cell and canalicular adenomas. Setting.—Archival pathology material from the files Henry Ford Hospital, Detroit, Mich, University California at San Francisco. Results.—All adenoma variants exhibit some degree participation with...
Barrett's esophagus (BE) is a premalignant lesion of the distal in which squamous epithelial cells are replaced by metaplastic intestinal-like columnar epithelium that contains goblet cells. The factors contribute to progression from normal mucosa BE, dysplasia, and adenocarcinoma not well understood at molecular level. Since reflux bile acids associated with BE development, we speculate an apoptosis-resistant phenotype selected after long-term repeated exposure pulses acids. This will...
S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well squamous cell tumors of the skin, lung and breast. Although its expression correlated HER+ high-grade high risk progression, molecular mechanisms these S100A7-mediated tumorigenic effects are not known. Here, we showed for first time that epidermal growth factor (EGF) induces both MCF-7 MDA-MB-468 lines. We also observed decrease EGF-directed migration...