A5100642990- Liver physiology and pathology
- Tuberculosis Research and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Mycobacterium research and diagnosis
- Cerebrospinal fluid and hydrocephalus
- Diagnosis and treatment of tuberculosis
- RNA modifications and cancer
- Spinal Dysraphism and Malformations
- Liver Disease Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Meningioma and schwannoma management
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Traumatic Ocular and Foreign Body Injuries
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Facial Trauma and Fracture Management
- Parasites and Host Interactions
- Pancreatic function and diabetes
- Spinal Fractures and Fixation Techniques
- Fetal and Pediatric Neurological Disorders
- Folate and B Vitamins Research
Peking University First Hospital
2015-2024
Peking University
2015-2024
Nantong University
2014-2024
Affiliated Hospital of Nantong University
2014-2024
Shanghai Maritime University
2023
Capital Medical University
2011-2022
Second People's Hospital of NanTong
2015-2022
Shanghai University
2022
Northeast Agricultural University
2022
Institute of Clinical Research
2020
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB unaccounted for additional susceptibility loci most likely exist. We perform multistage genome-wide association study on 2949 pulmonary patients 5090 healthy controls (833 cases 1220 were genotyped) from Han Chinese population....
In the process of hepatic fibrosis, stellate cells (HSCs) can be activated by many inflammatory cytokines. The transforming growth factor-β1 (TGF-β1) is one main profibrogenic mediators. Recently, some studies have also shown that microRNAs (miRNAs) play essential roles in progress liver fibrosis being involved differentiation, fat metabolism and ECM production HSCs. expression miR-454 LX-2 treated with TGF-β1 fibrotic livers Schistosoma japonicum infection was detected qRT-PCR. role on then...
Background The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression liver fibrosis. Previous studies have demonstrated ability soluble egg antigens (SEA) from schistosomes inhibit HSC activation and induce in vitro. In this study, we aimed explore mechanism SEA-induced HSCs. Methodology/Principal Findings found that SEA could upregulate p53 DR5 downregulate p-Akt. HSCs induced by be reduced were treated with p53-specific siRNA...
Abstract Background Long non-coding RNA growth arrest specific 5 (GAS5) is a regulator in non-small cell lung cancer (NSCLC) progression. Nonetheless, the mechanism by which GAS5 exerts its biological function NSCLC cells remains unclear. Methods GAS5, miR-221-3p relative expression levels tissues and were examined qPCR. After gain-of-function loss-of-function models established, viability of H1299 A549 CCK-8 EdU assays. Cell migration invasion Transwell experiment. The binding sequence for...
Abstract Background Tuberculosis (TB) and type 2 diabetes mellitus (DM) are global health diseases with high morbidity mortality. Few studies have focused on platelet indices in TB-DM coinfection patients. The objective of this work was to analyze the TB, DM patients assess predictive value index for risk these diseases. Methods In total, 246 admitted our hospital were distributed into three groups (113 59 74 TB + DM). A total 133 individuals also recruited as healthy controls (HC). Platelet...
Endoplasmic reticulum (ER) chaperone Prolyl 4-hydroxylase, beta polypeptide (P4HB) has previously been identified as a novel target for chemoresistance in glioblastoma multiforme (GBM). Yet its functional roles glioma carcinogenesis remain elusive. In clinical analysis using human specimens and Gene Expression Omnibus (GEO) profiles, we found that aberrant expression of P4HB was correlated with high-grade malignancy an angiogenic phenotype glioma. Furthermore, upregulation conferred...
Background: Dexamethasone (DEXA) is commonly used to reduce brain swelling during neurosurgical procedures. DEXA, however, has many side-effects that can increase the risks of post-operative complications. In contrast, progesterone (PRO) fewer and been found be neuroprotective on traumatic injury (TBI). Whether PRO may as an alternative DEXA routine procedures not fully explored.Object: To compare effects surgical (SBI).Methods: Seventy-five adult male Sprague Dawley rats were randomized...
Abstract RADA16‐I is a synthetic type I self‐assembling peptide nanofiber scaffold (SAPNS) which may serve as novel biocompatible hemostatic agent. Its application in neurosurgical hemostasis, however, has not been explored. Although nontoxic and nonimmunogenic, its intrinsic acidity potentially provoke inflammation the surgically injured brain. We conducted an animal study to compare with fibrin sealant, commonly used agent, hypothesis that former would be comparable alternative. Using...
AbstractPrimary objective: Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events result protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect against oxidative damage modulate capacity of to cope with synaptic cognitive impairment.Research design: To date, however, no studies have investigated effects procyanidins (PC) on deficits after TBI. Methods Procedures: In present study, rats controlled cortical impact (CCI)...
Abstract Background There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB LTBI). CD27 has been suggested to play direct role active TB. Little known about individuals. Here, we tried investigate whether it populations. The expression of MTB-specific CD4 + T cells (“CD27 − ” “CD27 IFN-γ ”) was evaluated MTB-unexposed controls (HC), TB contacts (TB-C) SN-TB individuals by flow cytometry. sensitivity, specificity AUC (area under...
We established an aptamer fluorescence microscopy approach for rapid detection of MTB in clinical sputum samples. The use probes was proven to significantly increase the sensitivity smear microscopy.
Background: Post-operative volume of subdural fluid is considered to correlate with recurrence in chronic haematoma (CSDH). Information on the applications computer-assisted volumetric analysis patients CSDHs lacking.
Background: Penetrating orbital injuries constitute a significant threat to ocular and cerebral structures. The incidence of central nervous system damage from injury is related the anatomy characteristics penetrating object. involving brain stem are extremely rare.Objectives: To present an uncommon case discuss surgical management.Case study: A patient suffered by Bakelite comb which extended his left orbit through cavernous sinus pons. Complete occlusion segment internal carotid artery was...
Drinking is a risk factor for traumatic brain injury (TBI), and ethanol can aggravate the outcome by promoting edema. The mechanism involved not fully understood. It has been confirmed that aquaporin-4 (AQP4) vascular endothelial growth (VEGF) play pivotal roles in cytotoxic/vasogenic edema individually, both of these proteins are downstream regulatory factors hypoxia-inducible factor-1α (HIF-1α). In this study, we used fluid percussion (FPI) model rats to determine effects acute intake on...
Short-term folate deficiency has been linked to cognitive defects. Given folate's role in regulating nucleotide synthesis and DNA histone methylation, these changes are often altered gene expression might be controlled by specific regulatory networks. In our study we examined the effects of folic acid deficient or replete diets mice, containing either no source normal intake, beginning post-weaning persisting through end adult life at 18 mos. Our goal was assess levels cognition mice using...
Objective To retrospectively analyze the clinical characteristics and surgical experience of 10 adults with spinal extradural meningeal cysts (SEMCs) in thoracolumbar spine which may further provide evidence for decision-making. Methods Ten SEMCs were surgically treated enrolled this study. Clinical manifestations, imaging data, intraoperative findings postoperative outcome recorded. Results manifestations included motor sensory dysfunction lower limbs urination defecation disturbance. The...
Abstract Upon chronic damage to the liver, multiple cytokines stimulate hepatic stellate cells (HSCs), causing alterations of gene expression profiles and thus leading HSC activation, a key step in liver fibrogenesis. Activated HSCs are dominant contributors fibrosis. Bromodomain containing protein 4 (BrD4), an important epigenetic reader, was demonstrated concentrate on hundreds enhancers associated with genes involved profibrotic pathways, thereby directing activation fibrotic responses....