A5015197495- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Cell death mechanisms and regulation
- Viral gastroenteritis research and epidemiology
- Esophageal Cancer Research and Treatment
- Infant Nutrition and Health
- Cutaneous lymphoproliferative disorders research
- DNA Repair Mechanisms
- Lymphoma Diagnosis and Treatment
- Art History and Market Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Clinical Nutrition and Gastroenterology
- Nail Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Cancer, Lipids, and Metabolism
- Polyamine Metabolism and Applications
- Library Science and Administration
- Cancer Research and Treatments
- Redox biology and oxidative stress
- Cancer-related Molecular Pathways
- Eosinophilic Esophagitis
- Amino Acid Enzymes and Metabolism
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
University of Michigan
2021-2022
Michigan United
2021-2022
Stony Brook University
2021
University of Arizona
2003-2012
Arizona Oncology
2000-2012
Université du Québec
2012
CS Diagnostics
2011
Erlanger Health System
2011
Institute of Cell Biology and Neurobiology
2007-2009
Southern Arizona VA Health Care System
1983-2009
High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since deoxycholic (DOC) suggested to be important in cancer etiology, this study investigated whether DOC, at a high physiologic level, could carcinogen. Addition of 0.2% DOC for 8-10 months diet 18 wild-type mice induced colonic tumors 17 mice, including 10 cancers. antioxidant chlorogenic 0.007% DOC-supplemented significantly reduced tumor formation. These results...
Abstract Apoptosis has long been considered to be the prevailing mechanism of cell death in response chemotherapy. Currently, a more heterogeneous model tumor therapy is acknowledged wherein multiple modes combine generate overall response. The resulting mechanisms are likely determined by action drug, dosing regimen used, and genetic background cells within tumor. This study describes nonapoptotic docetaxel human breast cancer increasing progression (MCF-10A, MCF-7, MDA-mb-231). Docetaxel...
Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role against NEC development and major source epidermal growth factor (EGF) for neonates. The aim this study was to examine effect orally administered EGF on incidence in a neonatal rat model. Newborn rats were artificially fed either with factor-free substitute (RMS) or RMS supplemented 500 ng/ml (RMS+EGF). Experimental induced by exposure...
An essential element of successful e‐commerce is building relationships with consumers. All are based upon trust and in the online B2C environment absence physical cues increases reliance other elements to convey integrity engender trust. Isolates examines three components identified earlier studies as areas consumer concern. Within these parameters a number characteristics potentially might affect levels; this initial exploratory study whether appears vary by gender, it authors’ intention...
Abstract Epidemiological studies have suggested that the concentration and composition of fecal bile acids are important determining factors in etiology colon cancer. However, mechanism by which these compounds influence tumor development is not understood. To begin to elucidate their action, four acids, cholic acid, chenodeoxycholic deoxycholic acid (DCA), ursodeoxycholic were examined for effects on growth several different cell lines. We found incubating cells with or DCA caused...
Necrotizing enterocolitis (NEC) is a devastating intestinal disease of premature infants. Although end-stage NEC characterized histopathologically as extensive necrosis, apoptosis may account for the initial loss epithelium before full development disease. We have previously shown that epidermal growth factor (EGF) reduces incidence in rat model. EGF has been to protect enterocytes from apoptosis, mechanism EGF-mediated protection against not known. The aim this study was investigate if...
The presence of intracellular keratin was examined in 230 human neoplasms using indirect immunofluorescence on fresh frozen, acetone-fixed sections. use antikeratin antibodies raised rabbits against callus and purified by affinity chromatography proved to be a rapid, sensitive, reliable method demonstrating keratin. Epithelial tissues epithelial-derived were found contain keratin, whereas mesenchymal, lymphoreticular, or neural crest origin did not This technic is useful adjunct for the...
Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile acids as a focus of this review since high levels hydrophobic accompany Western-style diet, and play key role in carcinogenesis. describe how acid-induced stresses cause cell death susceptible cells, contribute to genomic instability surviving impose Darwinian selection on survivors enhance initiation progression cancer. The most likely major mechanisms which induce cells (DNA damage, endoplasmic...
The present study provides experimental data which indicate that the neutrophil is ideal for studying programmed cell death or apoptosis in vitro. Neutrophils can be obtained from human peripheral blood large numbers with minimal manipulation and are easily separated other leukocytes, providing nearly pure suspensions. life span vitro sufficiently short to allow observations made within eight hours after manipulation. also maintained serum-free, chemically defined media systematically...
The efficacy of dietary selenium supplementation is currently being evaluated in intervention trials. However, the biological mechanisms underlying cancer chemopreventive effects have yet to be elucidated. Selenium metabolism and polyamine biosynthesis are linked their common requirement for S-adenosylmethionine. Selenomethionine was predominant form supplement, therefore we anti-tumorigenic selenomethionine. We found that selenomethionine inhibited tumor growth (both A549 lung HT29 colon...
Of the 42 Merkel cell carcinomas that we studied, two showed numerous tubular structures within sheets and nests of small cells. The cells stained for both neuron-specific enolase keratin. keratin decorated a dot-like paranuclear structure. ducts positively carcinoembryonic antigen (CEA) CF-1 (cystic fibrosis-1, monoclonal antibody only stains eccrine duct acrosyringium). Electron microscopy performed on one case cytoplasmic dense-core neurosecretory granules intercellular lumina lined by...
Abstract Objectives: The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear. Our previous studies showed that BE tissues secrete interleukin-6 (IL-6) and express proteins associated with IL-6 signaling, including receptor, activated signal transducer activators transcription 3 (STAT3), antiapoptotic Bcl-xL Mcl-1. Here, we test hypothesis bile acids gastric acids, two components refluxate gastresophageal reflux disease, activate IL-6/STAT3 pathway....
Abstract In a postmortem study of patient with adult‐onset acid maltase deficiency (AMD), morphological abnormalities were confined to skeletal muscle and consisted vacuolar myopathy. Acid activity, however, was approximately 6% normal in muscle, liver, brain, 3% heart. Kinetic characteristics, inhibition by antibodies Zn++, showed that the residual activity “authentic” maltase. Neutral but decreased brain (55% normal) heart (19% normal). Although relative decrease similar different tissues,...