A5007635759- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Long-Term Effects of COVID-19
- TGF-β signaling in diseases
- RNA regulation and disease
- Hedgehog Signaling Pathway Studies
- Immune cells in cancer
- Muscle Physiology and Disorders
- COVID-19 Clinical Research Studies
- Genomics and Chromatin Dynamics
- Nerve injury and regeneration
- Immune Response and Inflammation
- Developmental Biology and Gene Regulation
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Axon Guidance and Neuronal Signaling
Montefiore Health System
2023-2024
Albert Einstein College of Medicine
2015-2024
John F. Kennedy Center for the Performing Arts
2012-2022
The Bronx Defenders
1985-2021
Montefiore Medical Center
2020
Neurological Surgery
2020
Kennedy Center
2010-2019
Institute for Stem Cell Biology and Regenerative Medicine
2018-2019
Institute of Behavioral Sciences
2005-2019
Stem Cell Institute
2018
Microglia are the resident macrophages of central nervous system and associated with pathogenesis many neurodegenerative brain inflammatory diseases; however, origin adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to homeostasis in brain. In contrast macrophage populations, we develop mice lack colony stimulating factor-1 (CSF-1) but absent CSF-1 receptor-deficient mice. vivo lineage tracing studies established derive...
Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability appropriately expand subcutaneous adipose tissue may be an reason for resistance and β cell failure. Mice lacking leptin while overexpressing adiponectin showed normalized glucose levels dramatically improved as well positively affected serum triglyceride levels. Therefore, modestly increasing of...
A major proportion of the mammalian transcriptome comprises long RNAs that have little or no protein-coding capacity (ncRNAs). Only a handful such transcripts been examined in detail, and it is unknown whether this class transcript generally functional merely artifact. Using situ hybridization data from Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) are expressed adult mouse brain found majority were associated with specific neuroanatomical regions, cell types, subcellular...
We compared neuropsychological findings in 28 longitudinally evaluated elderly subjects with their postmortem neuropathology, including senile plaque and neurofibrillary tangle counts from standardized sections. Nine of the were not demented when just prior to death. Numerous cortical plaques other changes Alzheimer9s disease (AD) occurred six nine nondemented old-old subjects. Five these had shown decline on yearly tests but cognitive impairment was too mild meet clinical criteria for...
Abstract Background Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and widely expressed in the brain. Results Here we show that many long ncRNAs exhibit dynamic expression patterns during neuronal oligodendrocyte (OL) lineage specification, neuronal-glial fate transitions, progressive stages OL elaboration including myelination. Consideration genomic context these dynamically regulated showed they were part complex transcriptional loci...
Abstract In the amyloidogenic pathway associated with Alzheimer disease ( AD ), amyloid precursor protein APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) that then γ‐secretase β‐amyloid (Aβ) found in senile plaques. previous reports, we and others have shown activity enriched mitochondria‐associated endoplasmic reticulum ER membranes MAM –mitochondrial connectivity function are upregulated . We now show C99, addition its localization endosomes, can also be ,...
Abstract Objective Acute encephalopathy may occur in COVID‐19‐infected patients. We investigated whether medically indicated EEGs performed acutely ill patients under investigation (PUIs) for COVID‐19 report epileptiform abnormalities and these are more prevalent positive than negative Methods In this retrospective case series, adult inpatient PUIs underwent acute and/or seizure‐like events. had 8‐channel headband (Ceribell; 20 positive, 6 negative); 2 routine EEGs. Overall, 26 Ceribell...
We have used bipotent postnatal cortical oligodendroglial-astroglial progenitor cells (O-2As) to examine the role of inductive signals in astroglial lineage commitment. O-2A undergo progressive oligodendroglial differentiation when cultured serum-free medium, but differentiate into astrocytes medium supplemented with FBS. now report that bone morphogenetic proteins (BMPs), a major subclass transforming growth factor β (TGFβ) superfamily, promote selective, dose-dependent O-2As concurrent...
The expression and functional properties of connexin36 (Cx36) were examined in two communication-deficient cell lines (N2A-neuroblastoma PC-12 cells) transfected with Cx36 hippocampal neurons that express the connexin endogenously. Transfected cells expressed expected 2.9 kb transcript immunoreactivity, whereas nontransfected devoid Cx36. relationship between steady-state junctional conductance ( g j ) transjunctional voltage was well described by a two-state Boltzmann equation....
Members of the bone morphogenetic protein (BMP) family have been implicated in multiple aspects neural development both CNS and peripheral nervous system. BMP ligands receptors, as well antagonist noggin, are expressed developing cerebral cortex, making BMPs likely candidates for regulating cortical development. To define role these factors we examined effects BMP2 BMP4 on cells vitro. Cells were cultured from embryonic day 13 (E13) E16 rat cortex absence or presence different concentrations...
Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones brain throughout embryonic, postnatal adult life, different neural cell types generated discrete temporospatial developmental windows. This might suggest that encounter signals during each stage, thus accounting for separate waves lineage commitment cellular differentiation. study demonstrates, however, responses to same class signals, bone morphogenetic...