A5024542798- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Immune cells in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Ultrasound and Hyperthermia Applications
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Photoacoustic and Ultrasonic Imaging
- COVID-19 and healthcare impacts
- Chemokine receptors and signaling
- Erythropoietin and Anemia Treatment
- Blood transfusion and management
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Immunotherapy and Immune Responses
- Cardiac Health and Mental Health
- Pregnancy and preeclampsia studies
Presbyterian Hospital
2020-2022
New York Hospital Queens
2019-2022
Cornell University
2020-2022
Texas Health Dallas
2018-2022
Weill Cornell Medicine
2021
Coney Island Hospital
2020
University of North Carolina at Chapel Hill
2010-2020
St. John's University
2020
NewYork–Presbyterian Hospital
2019
University of California, Los Angeles
2019
The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes clinical trials aimed at augmenting growth highlight the need for greater understanding of biology.The role endothelial nitric oxide synthase (eNOS) forming native (preexisting) collaterals remodeling disease are unknown or controversial issues, respectively.We compared healthy tissue after femoral artery ligation (FAL) wild-type eNOS-knockout (KO) mice. Perfusion FAL fell further...
Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment acute thrombo-occlusive diseases. Here we report the development an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing required dose drugs. We hypothesize that sub-megahertz, forward-looking ultrasound transducer with integrated microbubble injection tube is more advantageous efficient thrombolysis by enhancing cavitation-induced...
Abstract Background There are limited data on the characteristics of 30‐day readmission after hospitalization with coronavirus disease 2019 (COVID‐19). Objectives To examine rate, timing, causes, predictors and outcomes COVID‐19 hospitalization. Methods From 13 March to 9 April 2020, all patients hospitalized discharged alive were included in this retrospective observational study. Multivariable logistic regression was used identify readmission, a restricted cubic spline function utilized...
Rationale: Collaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass vessels when the trunk of 1 tree becomes narrowed vascular disease. The number and diameter (“extent”) native (preexisting) collaterals, plus their amount lumen enlargement (growth/remodeling) in occlusive disease, show remarkably wide variation among inbred mouse strains (eg, C57BL/6 BALB/c), resulting large differences models...
Abstract Studies of the influence osteoclast on bone development, in particular mineralization and formation highly organized lamellar architecture cortical by osteoblasts, have not been reported. We therefore examined micro- ultrastructure developing bones osteoclast-deficient CSF-1R-nullizygous mice (Csf1r−/− mice). Introduction: Colony-stimulating factor-1 receptor (CSF-1R)-mediated signaling is critical for osteoclastogenesis. Consequently, primary defect osteopetrotic Csf1r−/− severe...
Abstract CSF-1 is the major regulator of tissue macrophage development and function. A GM-CSF-dependent, receptor (CSF-1R)-deficient F4/80hiMac-1+Gr1–CD11c+ bone marrow (BMM) line (MacCsf1r−/−) was developed to study roles eight intracellular CSF-1R tyrosines phosphorylated upon activation. Retroviral expression wild-type rescued CSF-1-induced survival, proliferation, differentiation, morphological characteristics primary BMM. Mutation all failed rescue, whereas individual Y → F mutants...
Reperfusion times for ST-elevation myocardial infarction (STEMI) occurring in outpatients have improved significantly, but quality improvement efforts largely ignored STEMI hospitalized patients (inpatient-onset STEMI).To define the incidence and variables associated with treatment outcomes of who develop during hospitalization conditions other than acute coronary syndromes (ACS).Retrospective observational analysis STEMIs between 2008 2011 as identified California State Inpatient...
Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most patients. Mice deficient for the transcription factors E2F1 and E2F2 suffer from a chronic pancreatitis-like syndrome become diabetic. Surprisingly, onset can be prevented through bone marrow transplantation. The goal described studies was determine hematopoietic cell type responsible maintaining islets associated mechanism...
Major advances have been made in the treatment of ST-elevation myocardial infarction (STEMI) outpatients. In contrast, little is known about outcomes STEMI that occur patients hospitalized for a noncardiac condition.This was retrospective, single-center study inpatient STEMIs from January 1, 2007, to July 31, 2011. Forty-eight cases were confirmed be total 139 410 adult discharges. These older and more often female had higher rates chronic kidney disease prior cerebrovascular events compared...
The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) directly regulates the development of Paneth cells (PC) and influences proliferation cell fate in small intestine (SI). In present study, we have examined role CSF-1 CSF-1R large intestine, which lacks PC, steady state response to acute inflammation induced by dextran sulfate sodium (DSS). As previously shown mouse, immunohistochemical (IHC) analysis expression showed that is baso-laterally expressed on epithelial human colonic...