A5070128299- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Lymphatic System and Diseases
- Blood Pressure and Hypertension Studies
- Diagnosis and Treatment of Venous Diseases
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Erythropoietin and Anemia Treatment
- Heart Failure Treatment and Management
- Blood transfusion and management
- Inflammatory mediators and NSAID effects
University of Chicago
2016-2025
Atrium Health Wake Forest Baptist
2015-2024
University of Chicago Medical Center
2010-2023
Baylor College of Medicine
2022
Clinical Research Institute
2022
Agostino Gemelli University Polyclinic
2022
Institut Pasteur de Lille
2022
Centre Hospitalier Universitaire de Lille
2022
Cedars-Sinai Medical Center
2022
University of Illinois Chicago
2017-2020
The coronary artery calcium score (CACS) has been shown to predict future heart disease (CHD) events. However, the extent which adding CACS traditional CHD risk factors improves classification of is unclear.To determine whether a prediction model based on risk.CACS was measured by computed tomography in 6814 participants from Multi-Ethnic Study Atherosclerosis (MESA), population-based cohort without known cardiovascular disease. Recruitment spanned July 2000 September 2002; follow-up...
<h3>Context</h3>Risk markers including coronary artery calcium, carotid intima–media thickness, ankle-brachial index, brachial flow–mediated dilation, high-sensitivity C-reactive protein (CRP), and family history of heart disease (CHD) have been reported to improve on the Framingham Risk Score (FRS) for prediction CHD, but there are no direct comparisons these risk in a single cohort.<h3>Objective</h3>We compared improvement incident CHD/cardiovascular (CVD) 6 within intermediate-risk...
The appropriate dose of aspirin to lower the risk death, myocardial infarction, and stroke minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject controversy.Using an open-label, pragmatic design, we randomly assigned strategy 81 mg or 325 per day. primary effectiveness outcome was composite death from any cause, hospitalization for stroke, assessed time-to-event analysis. safety bleeding, also analysis.A total 15,076 were followed median...
<h3>Importance</h3> Clinical practice guidelines support home-based exercise for patients with peripheral artery disease (PAD), but no randomized trials have tested whether an intervention without periodic medical center visits improves walking performance. <h3>Objective</h3> To determine a consisting of wearable activity monitor and telephone coaching ability over 9 months in PAD. <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted at 3 US centers. Patients PAD were...
<h3>Importance</h3> Supervised high-intensity walking exercise that induces ischemic leg symptoms is the first-line therapy for people with lower-extremity peripheral artery disease (PAD), but adherence poor. <h3>Objective</h3> To determine whether low-intensity home-based at a comfortable pace significantly improves ability in PAD vs and nonexercise control. <h3>Design, Setting, Participants</h3> Multicenter randomized clinical trial conducted 4 US centers including 305 participants....
A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from higher level.
Background: The most appropriate score for evaluating the pretest probability of obstructive coronary artery disease (CAD) is unknown. We sought to compare Diamond-Forrester (DF) with 2 CAD consortium scores recently recommended by European Society Cardiology. Methods: included 2274 consecutive patients (age, 56±13 years; 57% male) without prior referred computed tomographic angiography. Computed angiography findings were used determine presence or absence (≥50% stenosis). compared DF...
Abstract Whether initiation of statins could increase survival free dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled randomized pragmatic clinical trial, will compare high‐intensity statin therapy (atorvastatin 40 mg) with placebo 20,000 community‐dwelling without cardiovascular disease, disability, or at baseline. Exclusion criteria include use the prior year for >5 inability to take statin. Potential participants are identified...
Background Few adults have ideal cardiovascular health ( CVH ). We studied associations of an overall score with subclinical disease and events. assessed whether varied by race/ethnicity. Methods Results Among 5961 participants in the Multi‐Ethnic Study Atherosclerosis, components were measured at baseline, 2000‐2002: systolic blood pressure, total cholesterol, fasting glucose, smoking, physical activity, diet, body mass index. Levels classified as (2 points), intermediate (1 point), poor (0...
In the general population, majority of cardiovascular events occur in people at low to moderate end population risk distribution. The 2013 American College Cardiology/American Heart Association guideline on treatment blood cholesterol recommends consideration statin therapy for adults with an estimated 10-year atherosclerotic disease (ASCVD) ≥7.5% based traditional factors. Whether use nontraditional markers can improve assessment those below this threshold is unclear.Using data from...
<h3>Importance</h3> Trans-fatty acids (TFAs) have deleterious cardiovascular effects. Restrictions on their use were initiated in 11 New York State (NYS) counties between 2007 and 2011. The US Food Drug Administration plans a nationwide restriction 2018. Public health implications of TFA restrictions are not well understood. <h3>Objective</h3> To determine whether NYS associated with fewer hospital admissions for myocardial infarction (MI) stroke compared without restrictions. <h3>Design,...
<h3>Importance</h3> Benefits of granulocyte-macrophage colony-stimulating factor (GM-CSF) for improving walking ability in people with lower extremity peripheral artery disease (PAD) are unclear. Walking exercise may augment the effects GM-CSF PAD, since exercise-induced ischemia enhances progenitor cell release and promote homing to ischemic calf muscle. <h3>Objectives</h3> To determine whether combined supervised treadmill improves 6-minute walk distance, compared alone alone; more than...
<h3>Importance</h3> Research shows that resveratrol, a sirtuin activator in red wine, improves exercise endurance and skeletal-muscle oxidative metabolism animals may enhance vascular function humans. Resveratrol supplement sales exceed $30 million annually the United States, but few data are available regarding its efficacy <h3>Objective</h3> To determine whether 125 mg/d or 500 mg/d, 6-minute walk performance patients with peripheral artery disease (PAD). <h3>Design, Setting,...
Cocoa and its major flavanol component, epicatechin, have therapeutic properties that may improve limb perfusion increase calf muscle mitochondrial activity in people with lower extremity peripheral artery disease (PAD).In a phase II randomized clinical trial, to assess whether 6 months of cocoa improved walking performance PAD, compared placebo.Six-month double-blind, trial which participants PAD were either beverage versus placebo beverage. The contained 15 g 75 mg epicatechin daily....