A5087872615- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Heart rate and cardiovascular health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Neonatal Respiratory Health Research
- Muscle Physiology and Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- TGF-β signaling in diseases
Columbia University Irving Medical Center
2016-2023
Memorial Sloan Kettering Cancer Center
2022-2023
NewYork–Presbyterian Hospital
2017-2022
Cardiovascular Research Foundation
2016-2022
Columbia University
2018-2022
Los Angeles Clinical Trials
2022
Cornell University
2022
New York Hospital Queens
2017-2021
Presbyterian Hospital
2020-2021
Texas Health Dallas
2021
Patients with obstructive left main coronary artery disease are usually treated coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients disease.
Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared coronary-artery bypass grafting (CABG), in patients left main artery disease are not clearly established.
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Capillary leakage and alveolar edema are hallmarks of acute lung injury (ALI). Neutrophils serum macromolecules enter alveoli, promoting inflammation. Vascular endothelial growth factor (VEGF) causes plasma in extrapulmonary vessels. Angiopoietin (Ang)-1 -4 stabilize vessels, attenuating capillary leakage. We hypothesized that VEGF Ang-1 modulate vessel the lung, contributing to pathogenesis ALI. examined a murine model lipopolysaccharide (LPS)-induced C57BL/6 129/J mice were studied at...
Abstract Aims The prognostic implications of periprocedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI) and artery bypass grafting (CABG) remain controversial. We examined the 3-year rates mortality among patients with without PMI undergoing left main randomized to PCI everolimus-eluting stents vs. CABG in large-scale, multicentre, prospective, EXCEL trial. Methods results By protocol, was defined using an identical threshold for [creatinine kinase-MB (CK-MB)...
Background: Atrial fibrillation (AF), mitral regurgitation (MR), and left ventricular (LV) ejection fraction have a complex interplay. We evaluated the role of AF in patients with heart failure moderate-to-severe or severe secondary MR enrolled randomized COAPT trial (Cardiovascular Outcomes Assessment MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) its impact on mechanisms outcomes MitraClip. Methods: were stratified by presence (n=327)...
The author recently reported ∼50% excess early mortality in patients with first-presentation ST-segment elevation myocardial infarction (STEMI) without standard modifiable cardiovascular risk factors (SMuRFs); the cause of this is not clear. aim study was to examine differences infarct characteristics and clinical outcomes versus SMuRFs (dyslipidemia, hypertension, diabetes mellitus, smoking). Individual-level data were pooled from 10 randomized percutaneous intervention (PCI) trials which...
Objective— Statins have been shown to increase endothelial nitric oxide synthase expression via enhanced mRNA stability. Because the poly(A) tail is an important determinant of transcript stability, we sought characterize effect statins on eNOS 3′ polyadenylation. Methods and Results— Endothelial cells treated with had a time- dose-dependent in transcripts long tails (75 160 adenosines). This was dependent 3-hydroxy-3-methylglutaryl (HMG)-coenxyme A (CoA) reductase inhibition observed both...
Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulus, the expression of which increases in skeletal muscle after exercise. Because exercise also accompanied by increased intramuscular reactive oxygen species (ROS) generation, we tested hypothesis that ROS stimulate VEGF production from myotubes. Differentiated C 2 12 myotubes exposed to ROS-producing agents exhibited concentration-dependent increase production, whereas undifferentiated myoblasts did not respond oxidants....
Abstract Objectives We sought to assess in‐hospital and long‐term outcomes of retrograde compared with antegrade‐only percutaneous coronary intervention for chronic total occlusion (CTO PCI). Background Procedural clinical following CTO PCI remain unknown. Methods Using the core‐lab adjudicated OPEN‐CTO registry, we PCI. Primary endpoints included were major adverse cardiac cerebrovascular events (MACCE) (all‐cause death, stroke, myocardial infarction [MI], emergency surgery, or clinically...
In the COAPT trial (Cardiovascular Outcomes Assessment of MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation), treatment heart failure (HF) patients with moderate-severe or severe secondary mitral regurgitation transcatheter valve repair (TMVr) using plus guideline-directed medical therapy (GDMT) reduced 2-year rates HF hospitalization and all-cause mortality compared GDMT alone. Whether benefits extend to previously implanted cardiac...