A5086458150- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Frailty in Older Adults
- Sodium Intake and Health
- Cardiovascular and exercise physiology
- Dementia and Cognitive Impairment Research
- Healthcare Systems and Public Health
- Cardiovascular Syncope and Autonomic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmaceutical Practices and Patient Outcomes
- Hormonal Regulation and Hypertension
- Geriatric Care and Nursing Homes
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Muscle Physiology and Disorders
- Aging and Gerontology Research
University of Utah
2016-2025
American Geriatrics Society
2014-2025
Geriatric Research Education and Clinical Center
2014-2024
John Wiley & Sons (United States)
2019-2023
VA Salt Lake City Healthcare System
2012-2021
Park University
2017-2020
Moss Landing Marine Laboratories
2019-2020
Hudson Institute
2019-2020
Lake City VA Medical Center
2020
Hanover College
2017
<h3>Importance</h3> The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. <h3>Objective</h3> To evaluate the effects of intensive (<120 mm Hg) compared standard (<140 SBP targets persons aged 75 years or but without diabetes. <h3>Design, Setting, and Participants</h3> A multicenter, randomized clinical trial who participated Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010,...
There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.To evaluate effect intensive blood pressure control on dementia.Randomized clinical trial conducted at 102 sites in United States Puerto Rico among adults aged 50 years or older with hypertension but without diabetes history stroke. Randomization began November 8, 2010. The was stopped early for benefit its primary outcome (a composite cardiovascular events) all-cause mortality August 20,...
The effect of intensive blood pressure lowering on brain health remains uncertain.To evaluate the association treatment with cerebral white matter lesion and volumes.A substudy a multicenter randomized clinical trial hypertensive adults 50 years or older without history diabetes stroke at 27 sites in United States. Randomization began November 8, 2010. overall was stopped early because benefit for its primary outcome (a composite cardiovascular events) all-cause mortality August 20, 2015....
The previously published results of the Systolic Blood Pressure Intervention Trial showed that among participants with hypertension and an increased cardiovascular risk, but without diabetes, rates events were lower those who assigned to a target systolic blood pressure less than 120 mm Hg (intensive treatment) 140 (standard treatment). Whether such intensive treatment affected patient-reported outcomes was uncertain; from trial are reported here.We randomly 9361 blood-pressure or Hg....
The Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk developing dementia. However, an insufficient number probable dementia cases stemming from trial's early termination made results inconclusive. goal this study was to estimate effect vs standard SBP on longer term incidence cognitive impairment leveraging extended follow-up for status. This is a prespecified secondary analysis randomized clinical trial. Between...
Importance The patient portal has a growing role in health care. Many systems have implemented shared access functionality which patients may register care partner with unique identity credentials to their portal. Uptake of been limited. Objective To examine the outcomes multisite demonstration involving organizational strategies associated registration and use access. Design, Setting, Participants This quality improvement study was conducted diverse sites within 3 US: (1) geriatric...
A number of methods exist for the estimation abdominal obesity, ranging from waist-to-hip ratio to computed tomography (CT). Although dual-energy X-ray absorptiometry (DXA) was originally used measure bone density and total body composition, recent improvements in software allow it determine fat mass. Sixty-five men women aged 18-72 yr participated a series studies examine validity reliability DXA accurately fat. Total regional were measured by using Lunar DPX-IQ. Multislice CT scans...
The Systolic Blood Pressure Intervention Trial (SPRINT) is testing whether a lower systolic blood pressure (BP) target of 120mm Hg leads to reduction in cardiovascular morbidity and mortality among hypertensive, nondiabetic adults. Because there may be detrimental effects intensive BP control, particularly older, frail adults, we sought characterize frailty within SPRINT address ongoing questions about the ability large-scale trials enroll representative samples noninstitutionalized,...
Four hundred and eighty-nine independent Nif- strains containing 260 point, 130 millimicron-induced, 99 deletion mutations in nif the Klebsiella pneumoniae chromosome were isolated. Three ninety insertion point mapped with millimicron-induced deletions carried on 44 plasmids derived from pTM4010, a recombinant R factor his-nif region of K. pneumoniae. The chromosomal 69 derivatives pTM4010 carrying nif. Complementation analysis between 84 Rec- 390 mutants identified 14 genes. ordered into 49...
The Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure control reduced cardiovascular morbidity and mortality. However, the legacy effect of treatment is unknown.To evaluate long-term effects randomization to with incidence all-cause mortality approximately 4.5 years after trial ended.In this secondary analysis a multicenter randomized clinical trial, began on November 8, 2010, intervention ended August 20, 2015, close-out visits occurred through July...
Abstract Whether initiation of statins could increase survival free dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled randomized pragmatic clinical trial, will compare high‐intensity statin therapy (atorvastatin 40 mg) with placebo 20,000 community‐dwelling without cardiovascular disease, disability, or at baseline. Exclusion criteria include use the prior year for >5 inability to take statin. Potential participants are identified...
This study examined medical students' interest in geriatrics: Are knowledge, positive attitudes, and prior experience with older adults associated an geriatric medicine?Entering University of Michigan students completed three surveys: the Revised Facts on Aging Quiz, California at Los Angeles Geriatric Attitudes Scale, Maxwell-Sullivan Scale. The were also asked questions about their medicine.The results indicate that incoming have minimal knowledge aging, moderately attitudes toward adults,...
We tested the hypotheses that 1) there is an age-associated decrease in arterial alpha-adrenergic responsiveness and 2) upregulation of this response during suppression sympathetic nervous system (SNS) activity. measured forearm blood flow (FABF) by plethysmography brachial artery infusions agonist norepinephrine (NE) nonadrenergic angiotensin II (ANG II) 15 young 14 older healthy human subjects. Among old (O) relative to (Y) we identified greater plasma NE levels (Y: 1.29 +/- 0.07 nM vs. O:...
In subjects with type 2 diabetes in whom an impaired response to endothelial-dependent vasodilator has been characterized, the populations have also at least moderately obese. Obesity characterized as independent predictor of endothelial dysfunction nondiabetic subjects. We hypothesized that normotensive compared age-matched control subjects, 1) endothelium-dependent vasodilation, demonstrated by forearm blood flow (FABF) intraarterial acetylcholine, would be decreased; 2)...
In the peripheral circulation, nitric oxide (NO) is released in response to shear stress across vascular endothelial cells. We sought assess degree which NO contributes exercise-induced vasodilation brachial artery (BA) and determine potential of this approach noninvasively evaluate bioavailability. eight young (25 ± 1 yr) healthy volunteers, we used ultrasound Doppler examine BA handgrip exercise (4, 8, 12, 16, 20, 24 kg) with without synthase blockade [intra-arterial N G...
Objective To determine predictors of serious adverse events ( SAE s) involving syncope, hypotension, and falls, with particular attention to age, in the Systolic Blood Pressure Intervention Trial. Design Randomized clinical trial. Setting Academic private practices across United States (N = 102). Participants Adults aged 50 older a systolic blood pressure SBP ) 130 180 mmHg at high risk cardiovascular disease events, but without diabetes, history stroke, symptomatic heart failure or ejection...
Abstract Dysregulated inflammation is implicated in the pathobiology of aging, yet platelet–leukocyte interactions and downstream cytokine synthesis aging remains poorly understood. Platelets monocytes were isolated from healthy younger (age &lt;45, n = 37) older ≥65, 30) adults incubated together under autologous nonautologous conditions. Synthesis inflammatory cytokines by monocytes, alone or presence platelets, was examined. Next-generation RNA-sequencing allowed for unbiased...
The learning health care system promotes development and application of evidence generated within the to enhance quality patient care. purpose this study was understand resident attitudes about improvement (QI) in Accreditation Council for Graduate Medical Education-approved programs.Four focus groups were conducted with 45 residents at University Utah School Medicine during September October 2014. Residents discussed perceived value QI their experiences QI. Qualitative analysis iteratively,...
Background.Aging-related changes in platelet and monocyte interactions may contribute to adverse outcomes sepsis but remain relatively unexamined. We hypothesized that differential platelet–monocyte aggregate (PMA) formation older septic patients alters inflammatory responses mortality.
To evaluate the effect of intensive systolic blood pressure (SBP) control in older adults with hypertension, considering cognitive and physical function.Secondary analysis.Systolic Blood Pressure Intervention Trial (SPRINT) PARTICIPANTS: Adults 80 years or older.Participants hypertension but without diabetes (N = 1167) were randomized to an SBP target below 120 mm Hg (intensive treatment) vs a 140 (standard treatment).We measured incidence cardiovascular disease (CVD), mortality, changes...