A5016566914- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- Antiplatelet Therapy and Cardiovascular Diseases
- Polymer Surface Interaction Studies
- Protein Interaction Studies and Fluorescence Analysis
- Hemodynamic Monitoring and Therapy
- Angiogenesis and VEGF in Cancer
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Pharmaceutical industry and healthcare
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Healthcare Operations and Scheduling Optimization
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Health and Disease Prevention
- MicroRNA in disease regulation
- Pharmaceutical Economics and Policy
- Ultrasound and Hyperthermia Applications
- Mesenchymal stem cell research
- Healthcare Policy and Management
- Hippo pathway signaling and YAP/TAZ
- Antioxidant Activity and Oxidative Stress
Kyung Hee University
2024
Johns Hopkins University
2008-2022
Johns Hopkins Medicine
2015-2022
Clinical Trial Investigators
2022
Alabama College of Osteopathic Medicine
2022
Renmin University of China
2021
Johns Hopkins Bayview Medical Center
2018
National Institutes of Health
2016
Harvard–MIT Division of Health Sciences and Technology
1999-2009
Brigham and Women's Hospital
2001-2009
The mechanism of action the Vacuum Assisted Closure Therapy (VAC; KCI, San Antonio, Texas), a recent novel innovation in care wounds, remains unknown. In vitro studies have revealed that cells allowed to stretch tend divide and proliferate presence soluble mitogens, whereas retracted remain quiescent. authors hypothesize application micromechanical forces wounds vivo can promote wound healing through this cell shape-dependent, mechanical control mechanism. created computer model (finite...
Background The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, yet they have failed to stop restenosis clinically. More recent compounds, paclitaxel, are a different sort, being hydrophobic in nature, their effects after local release seem far more profound. This dichotomy raises question whether drugs that an effect when released from stent do so because differences biology or physicochemical...
Endovascular drug-eluting stents have changed the practice of medicine, and yet it is unclear how they so dramatically reduce restenosis to distinguish between different formulations available. Biological drug potency not sole determinant biological effect. Physicochemical properties also play important roles. Historically, two classes therapeutic compounds emerged: hydrophobic drugs, which are retained within tissue dramatic effects, hydrophilic rapidly cleared ineffective. Researchers now...
Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as whether thrombi affect drug elution and uptake.Paclitaxel transport retention were assessed in clots of different blood components. Diffusivity, affected by organization, is fastest fibrin (approximately 347 microm2/s), slower fibrin-red cell (34.98 slowest whole-blood (3.55 microm2/s). Blood cells bind retain paclitaxel such that levels increase linearly...
An incomplete understanding of the transport forces and local tissue structures that modulate drug distribution has hampered pharmacotherapies in many organ systems. These issues are especially relevant to arteries, where stent-based delivery allows fine control locally directed release. Local produces tremendous concentration gradients although these part derived from forces, differences deposition imply ultrastructure also plays an important role. We measured equilibrium uptake penetration...
The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized angiogenic therapies powerfully self-regulate by dynamically altering tissue characteristics. Induced neocapillaries increase drug clearance and limit retention subsequent even the face delivery.We quantified how capillary flow clears fibroblast growth factor after local epicardial delivery. Fibroblast spatial loading was...
Background Prevention of adverse remodeling after myocardial infarction ( MI) is an important goal stem cell therapy. Clinical trial results vary, however, and poor retention survival delivery likely limit the opportunity to exert beneficial effects. To overcome these limitations, we built implantable intravascular bioreactor IBR ) designed protect contained cells from washout, dilution, immune attack while allowing sustained release paracrine factors. Methods Results s were constructed...
Exosomes are extracellular nanovesicles secreted by cells that efficiently deliver therapeutic cargo for cancer treatment. However, because exosomes present in low quantities and have limited target specificity, internal external stress stimulation has been studied to increase exosome efficiency. Inspired these studies, the uptake efficiency of cobalt chloride-induced hypoxic cell-secreted was evaluated. Western blotting RT-PCR data revealed increased secretion different protein compositions...
Age-related differences in stem-cell potency contribute to variable outcomes clinical stem cell trials. To help understand the effect of age on potency, bone marrow-derived mesenchymal cells (MSCs) were isolated from young (6 weeks) and old (18-24 months) mice. HUVEC tubule formation (TF) induced by MSCs ELISA conditioned media compared one another, after 7 d indirect co-culture with MSCs. Old less TF than did (1.56 ± 0.11 vs 2.38 0.17, p = 0.0003) released lower amounts VEGF (p 0.009) IGF1...
Radiolabeled drug-eluting stents have been proposed recently as a novel method to potentially reduce restenosis in coronary arteries. A P-32 labeled oligonucleotide (ODN) loaded on polymer coated stent is slowly released the arterial wall deliver therapeutic dose target tissue. However, relatively low proportion of drugs transferred typically) raises questions about degree which radiolabeled eluted from can contribute total radiation delivered tissues. three-dimensional diffusion-convection...
Problem Definition: Among the most vexing issues in U.S. healthcare ecosystem is inappropriate usage of percutaneous coronary intervention (PCI) procedures, also known as “overstenting.” A key driver overstenting physician subjectivity “eyeballing” a angiogram. Advanced tests such fractional flow reserve (FFR) provide more precise and objective measures PCI appropriateness, yet decision to perform these endogenous not immune clinical ambiguity associated with “eyeballing.” Additionally,...
Objectives To compare bivalirudin to heparin during non-primary percutaneous coronary intervention (PCI). Background The optimal anticoagulant support PCI remains uncertain. Methods We performed a propensity score-based analysis comparing clinical outcomes of patients receiving those PCI. Results Of 18,867 in the Cardiovascular Patient Outcomes Research Team Non-Primary (CPORT-E) trial, we selected 7,913 undergoing non-staged whom 57.3% received and 42.7% bivalirudin. In-hospital myocardial...
Local growth factor (GF) delivery is an attractive mode of vascular regenerative therapy for ischemic tissues. Yet, local release proangiogenic GFs does not produce a sustained angiogenic response in clinical trials. We hypothesize that therapies are self-regulated by dynamically altering tissue transport characteristics. Induced neocapillaries increase drug clearance rates, limiting levels and induced vessel growth. examined the interdependence FGF distribution angiogenesis rabbit heart...
Abstract Cardiovascular diseases (CVDs) are the leading cause of death and disability both in United States worldwide. Despite high morbidity, mortality, cost global healthcare systems, cardiovascular care has been understudied operations management literature. In this paper, we identify research opportunities for scholars to aid improving care. We focus on three burdensome conditions, including (1) coronary artery disease, (2) stroke, (3) heart failure, which, collectively, lead vast...
Problem definition: Among the most vexing issues in U.S. healthcare ecosystem is inappropriate use of percutaneous coronary intervention (PCI) procedures, also known as overstenting. A key driver overstenting physician subjectivity eyeballing a angiogram. Advanced tests such fractional flow reserve (FFR) provide more precise and objective measures PCI appropriateness, yet decision to perform these endogenous not immune clinical ambiguity associated with eyeballing. Additionally, conflicts...
Background: Results of stem cell studies for cardiomyopathy and peripheral artery disease are promising, but benefits remain modest in part due to washout immune attack. Evidence suggests that many effects paracrine-mediated, wherein secreted factors activate intrinsic repair. We now describe a impregnated nanofiber (NF) stent sleeve which biodegradable NF is electrospun around with large number cells. The porous nanostructure prevents attack, allows sustained local production secretion...