A5029547026- Immune Cell Function and Interaction
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- Reproductive System and Pregnancy
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Erythrocyte Function and Pathophysiology
- Advanced Radiotherapy Techniques
- Fibroblast Growth Factor Research
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
Jinan University
2025
Southern University of Science and Technology
2025
Beijing Friendship Hospital
2018-2024
Capital Medical University
2018-2024
Southern Medical University
2024
Nanfang Hospital
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2021
Abcombi Biosciences (United States)
2020-2021
Sun Yat-sen University
2020
Shantou University
2018
To understand the system of secreted proteins and receptors involved in cell-cell signaling, we produced a comprehensive set recombinant extracellular domains transmembrane proteins, which constitute most protein components space. Each was tested suite assays that measured metabolic, growth, or transcriptional responses diverse cell types. The pattern across analyzed for degree functional selectivity each protein. One highly selective previously undescribed ligand, designated interleukin-34...
CSF-1 is broadly expressed and regulates macrophage osteoclast development. The action expression of IL-34, a novel CSF-1R ligand, were investigated in the mouse. As expected, huIL-34 stimulated proliferation via huCSF-1R, equivalently to huCSF-1, but was much less active at stimulating mouse than huCSF-1. Like muCSF-1, muIL-34 isoform lacking Q81 proliferation, tyrosine phosphorylation, signaling synergized with other cytokines generate macrophages osteoclasts from cultured progenitors....
Abstract Purpose The objective of this study was to identify potential predictors immune-related adverse events (irAEs) in cancer patients receiving immune checkpoint inhibitor therapy among serum indexes, case data, and liquid biopsy results. Methods We retrospectively analyzed 418 treated with anti-programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) inhibitors from January 2018 May 2022 our center. identified factors that correlated the occurrence irAEs evaluated associations between...
The interleukin-1 (IL-1) family members play an important role in the process of inflammation and host defense. We describe here identification characterization a novel member IL-1 family, IL-1HY2. human IL-1HY2 protein shares significant amino acid sequence similarity (37%) with receptor antagonist has predicted three-dimensional structure similar to that antagonist. TheIL-1HY2 gene is located close proximity other genes on chromosome 2, genomic organization theIL-1HY2 highly conserved...
CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, pharmacological inhibition is beneficial in animal models arthritis. The objective this study was to determine the relative contributions signaling RA. were detected by immunohistochemical digital image analysis synovial tissue from 15 biological-naïve rheumatoid arthritis (RA) , psoriatic (PsA) 7 osteoarthritis (OA) patients . Gene expression CSF-1- IL-34-differentiated human...
Background Uveal melanoma (UVM) is a form of eye cancer with poor prognosis, particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity within UVM and identify prognostic biomarkers. Methods We performed single-cell RNA sequencing (scRNA-seq) on primary samples. A UVM-specific gene signature was constructed using LASSO regression validated via ROC curve analysis TCGA-UVM GSE84976 cohorts. AlphaFold 3 used predict 3D structures key proteins. T-cell...
Abstract Traditional observational research has revealed an association between severe COVID-19 and chronic kidney disease (CKD). It is unclear whether there a causative connection them. Our goal was to determine genetically predicted CKD associated with the risk of critical COVID-19. We aimed investigate potential underlying genetic mechanisms that could explain this relationship, paving way for personalized assessment targeted interventions mitigate effects on individuals CKD. Using...
Abstract Radiation‐induced intestinal injury (RIII) is a common complication after radiation therapy in patients with pelvic, abdominal, or retroperitoneal tumours. Recently, the model of DSS (Dextran Sulfate Sodium Salt) ‐induced inflammatory injury, it has been found study that transgenic mice expressing hVDR IEC (Intestinal Epithelial Cell) manifest highly anti‐injury properties colitis, suggesting activated VDR epithelial cells intestine may inhibit colitis by protecting mucosal barrier....
The quail fast skeletal troponin I (TnI) gene is a member of the contractile protein set and expressed exclusively in differentiated muscle cells. TnI transcription controlled by an internal regulatory element (IRE), located within first intron, that functions as muscle-specific enhancer. Recent studies have shown IRE may interact directly with factors MyoD, myogenin, Myf-5 to produce expression pattern, since these trans-activate cotransfected constructs C3H10T1/2 fibroblasts. In this...
Background: Radiotherapy is a standard treatment for significant fraction of cancer patients. Nonetheless, to this day radiation resistance key impediment in gastric (GC) treatment. Moreover, GC characterized by its substantial neo-angiogenesis, driven high levels vascular endothelial growth factor (VEGF) correlated with the presence stomach cancer. The aim our study was address if VEGFR inhibitors treatments impact negative effect radiotherapy regiments Materials and methods: Isolation...
KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play central role in transcriptional repression. C-Jun proto-oncogene promotes cell proliferation when ectopically accumulated, but can be ubiquitinated by SCF (FBXW7), leading its degradation. FBXW7 an E3 ubiquitin ligase of c-Jun, exhibits carcinostasis colon cancer. Here, we report overexpression human cancer cells results attenuated transcription accumulated c-Jun protein, increased...
Objective: Cancer stem cells play a crucial role in tumor multidrug resistance and metastasis, which can produce heterogeneous have self-renewal ability. The related literature reported that PRMT8 was overexpressed pluripotent cells. However, it's unclear how acts on the stemness of colon This study is designed to detect functions by transfecting with plasmid cancer Methods: In this we investigated cell sphere its differential expression compared grown static adherence. RKO Sphere formation...
Abstract Esophageal cancer (ESCA) is one of the most fatal gastrointestinal cancers worldwide. ESCA often diagnosed in its middle or late stages since first symptoms are not identifiable. The use radiotherapy, either alone conjunction with surgical intervention and chemotherapy, essential to achieve a positive prognosis. Radiotherapy an component treatment for ESCA. Autophagy, prevalent biological phenomenon, has twofold impact on incidence, progression, response malignant tumors. This...
BACKGROUND Lin28 is a gene involved in many biological processes, including development, glucose metabolism, and tumorigenesis. Let-7 miRNA tumor-suppressor that frequently inactivated cancer cells. The role of c-Myc (a target let-7) the Lin28-let-7-c-Myc pathway growth malignancy thyroid unclear. purpose present study was to evaluate expression Lin28A, let-7a, human papillary carcinoma (PTC) investigate their potential mechanisms progression PTC. MATERIAL AND METHODS Lin28A were assessed...
Aims: Pyrotinib is a newly developed irreversible pan-ErbB receptor tyrosine kinase inhibitor for treatment of human epidermal growth factor 2 (HER2)-positive cancers, and clinic trials pyrotinib in HER2-positive gastric cancer (GC) are underway. Exosomes tiny vesicles secreted by cells take essential roles the progression carcinoma. Whether application has any effect on cell-released exosomes not been studied. The aim our work was to address if impacts GC cell-derived endothelial cell (EC)...