A5101810550- Ubiquitin and proteasome pathways
- Radio Frequency Integrated Circuit Design
- TGF-β signaling in diseases
- Microwave Engineering and Waveguides
- Electromagnetic Compatibility and Noise Suppression
- Acute Ischemic Stroke Management
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Melanoma and MAPK Pathways
- HER2/EGFR in Cancer Research
- Biochemical and Molecular Research
- Synthesis and biological activity
- Cerebrovascular and Carotid Artery Diseases
- Enzyme Structure and Function
- Plant Stress Responses and Tolerance
- Phytochemistry and Biological Activities
- Advancements in PLL and VCO Technologies
- Protein Structure and Dynamics
- Protein purification and stability
- Immune Cell Function and Interaction
- Muscle activation and electromyography studies
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
Sichuan Agricultural University
2025
State Forestry and Grassland Administration
2025
National University of Defense Technology
2025
Zhejiang Chinese Medical University
2025
Xiamen University
2014-2024
Jilin Medical University
2020-2024
Jilin University
2020-2024
Heilongjiang Bayi Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Shaanxi University of Chinese Medicine
2024
The transition of cells from an epithelial to a mesenchymal phenotype is critical event during morphogenesis in multicellular organisms and underlies the pathology many diseases, including invasive associated with metastatic carcinomas. Transforming growth factor beta (TGFbeta) key regulator epithelial-to-mesenchymal (EMT). However, molecular mechanisms that control dissolution tight junctions, early EMT, remain elusive. We demonstrate Par6, cell polarity tight-junction assembly, interacts...
The Rho family of small guanosine triphosphatases regulates actin cytoskeleton dynamics that underlie cellular functions such as cell shape changes, migration, and polarity. We found Smurf1, a HECT domain E3 ubiquitin ligase, regulated polarity protrusive activity was required to maintain the transformed morphology motility tumor cell. Atypical protein kinase C zeta (PKCzeta), an effector Cdc42/Rac1-PAR6 complex, recruited Smurf1 protrusions, where it controlled local level RhoA. thus links...
Abstract Fatty acids (FAs) are essential nutrients, but how they transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers adipocytes. During the process, binding of to activates its downstream kinase LYN, phosphorylates DHHC5, palmitoyl acyltransferase CD36, at Tyr91 and inactivates it. then gets depalmitoylated by APT1 recruits another tyrosine SYK phosphorylate JNK VAVs initiate endocytic uptake FAs. Blocking...
A wideband noise-cancelling low-noise amplifier (LNA) without the use of inductors is designed for low-voltage and low-power applications. Based on common-gate-common-source (CG-CS) topology, a new approach employing local negative feedback introduced between parallel CG CS stages. The moderate gain at source cascode transistor in stage utilized to boost transconductance transistor. This leads an LNA with higher lower noise figure (NF) compared conventional CG-CS LNA, particularly under low...
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss Mst1/2, mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably enlarged endoplasmic reticulum (ER) size-associated UPR. Intriguingly, attenuation UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis promoting nuclear exit degradation downstream effector Yap. Yap is required for activity ER expansion...
Fatty acid uptake is the first step in fatty utilization, but it remains unclear how process regulated. Protein palmitoylation a acyl modification that plays key regulatory role protein targeting and trafficking; however, its function regulating metabolism unknown. Here, we show two of Asp-His-His-Cys (DHHC) motif-containing palmitoyl acyltransferases, DHHC4 DHHC5, regulate uptake. DHHC5 at different subcellular localizations to control palmitoylation, plasma membrane localization, activity...
Triple-negative breast cancer (TNBC) is a subtype of with poor outcome and lacks approved targeted therapy. Overexpression epidermal growth factor receptor (EGFR) found in more than 50% TNBC suggested as driving force progression TNBC; however, targeting EGFR using antibodies to prevent its dimerization activation shows no significant benefits for patients. Here we report that monomer may activate signal transducer activator transcription-3 (STAT3) the absence transmembrane protein TMEM25,...
Acute ischemic stroke (AIS) remains to be a challenging cerebrovascular disease. The mainstay of AIS management is endovascular reperfusion therapy, including thrombectomy and thrombolysis. However, ineffective (futile) (FR) or injury (RI) can seen in significant number patients undergoing strategy. In this article, we discuss two clinically relevant concepts known as "time window" "tissue that impact the clinical outcome therapy. We also explore patient risk factors, leading FR RI well an...
Multiple myeloma is an incurable hematologic cancer characterized by the clonal proliferation of malignant plasma cells within bone marrow. Numerous studies suggest that occupy and alter stromal tissue marrow as a means enhancing their survival growth. However, nature magnitude changes to cell remain be determined. In this study, we used mesenchymal osteoblast-related surface marker expression (STRO-1 alkaline phosphatase, respectively) flow cytometry enumerate osteoblast numbers in...
RAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving E3 ligase Nedd4-1, Ras, and PTEN. We found that signaling stimulates expression of which turn acts as an ubiquitin regulates levels. Importantly, activation, either by oncogenic mutations or epidermal growth factor (EGF) signaling, prevents Nedd4-1-mediated ubiquitination. This leads to Ras-induced Nedd4-1...
Abstract Aberrant activation of EGFR due to overexpression or mutation is associated with poor prognosis in many types tumors. Here we show that blocking the sorting system directs plasma membrane a potent strategy treat EGFR-dependent We find palmitoylation by DHHC13 critical for its localization and identify ARF6 as key factor this process. N-myristoylated recognizes palmitoylated via lipid-lipid interaction, recruits exocyst complex promote budding from Golgi, facilitates transporting...