A5070506894- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Clinical Laboratory Practices and Quality Control
- Cardiovascular Effects of Exercise
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Meta-analysis and systematic reviews
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Healthcare cost, quality, practices
- Lipoproteins and Cardiovascular Health
- Prostate Cancer Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Prostate Cancer Treatment and Research
McMaster University
2016-2025
Hamilton Health Sciences
2016-2025
Hamilton Regional Laboratory Medicine Program
2010-2025
Juravinski Hospital
2014-2024
Galveston College
2023
Société Française de Cardiologie
2023
Walter de Gruyter (Germany)
2023
St Vincent's Hospital Sydney
2023
Mirpur University of Science and Technology
2023
Azienda Ospedaliera di Padova
2023
Abstract Background: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial due to ischemia that occurs during or within 30 days surgery. The study’s four objectives were determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS. Methods: In this international, prospective cohort study 15,065 patients aged 45 yr older who underwent in-patient surgery, troponin T measured first 3 postoperative days. Patients with a...
Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality myocardial injury after noncardiac surgery (MINS).To determine association hsTnT potential diagnostic criteria for MINS (ie, due to ischemia associated with mortality).Prospective cohort study of patients aged 45 years or older who underwent inpatient had a postoperative measurement. Starting in October 2008, participants were recruited at 23 centers 13...
Abstract This document is an essential companion to the third iteration of National Academy Clinical Biochemistry [NACB,8 now American Association for Chemistry (AACC) Academy] Laboratory Medicine Practice Guidelines (LMPG) on cardiac markers. The expert consensus recommendations were drafted in collaboration with International Federation and Task Force Applications Bio-Markers (IFCC TF-CB). We determined that there sufficient clinical guidance use troponin (cTn) testing from practice...
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful determining probability and subsequent 30-day outcomes.
Inflammation has an integral role in the pathophysiology of AKI. We investigated associations two biomarkers inflammation, plasma IL-6 and IL-10, with AKI mortality adults undergoing cardiac surgery. Patients were enrolled at six academic centers (n=960). was defined as a ≥50% or ≥0.3-mg/dl increase serum creatinine from baseline. Pre- postoperative IL-10 concentrations categorized into tertiles evaluated for outcomes in-hospital postdischarge all-cause median 3 years after Preoperative not...
Consensus recommendations regarding the threshold levels of cardiac troponin elevations for definition perioperative myocardial infarction and clinically important periprocedural injury in patients undergoing surgery range widely (from >10 times to ≥70 upper reference limit assay). Limited evidence is available support these recommendations.
BACKGROUND In recent years, there has been increasing focus on the use of cardiac biomarkers in patients undergoing noncardiac surgery. AIMS The aim this focused guideline was to provide updated guidance regarding pre-, post- and combined pre-and postoperative troponin B-type natriuretic peptides adult METHODS guidelines were prepared using Grading Recommendations Assessment Development Evaluation (GRADE) methodology. This included definition critical outcomes, a systematic literature...
The American Heart Association (AHA) case definition for acute myocardial infarction (AMI) requires an "adequate set" of biomarkers: 2 measurements the same marker at least 6 h apart. A sensitive troponin assay might detect significant changes in concentration earlier. We determined AMI prevalence, using protocols with shorter intervals between measurements, and without incorporating time from onset symptoms.The AHA was used to retrospectively assign a diagnosis 258 patients presenting...
Abstract Background: Improvements in cardiac troponin (cTn) assays have increased the rapidity with which clinicians can identify patients changing cTn concentrations (rise or fall) indicative of acute myocardial injury. The aim present study was to characterize a new, high-sensitivity cTnI (hs-cTnI) assay and examine whether sensitivity result still earlier detection evolving Methods: We determined limit detection, precision profiles, preliminary estimates 99th percentile for Beckman...
Background: Preliminary data suggest that preoperative N-terminal pro–B-type natriuretic peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac surgery. Objective: To determine whether NT-proBNP has additional predictive value beyond a clinical score for the composite of vascular death and myocardial injury after surgery (MINS) within 30 days Design: Prospective cohort study. Setting: 16 hospitals 9 countries. Patients: 10 402 aged 45 years or older having...
Background: The new European Society of Cardiology guidelines to rule-in and rule-out acute myocardial infarction (AMI) in the emergency department include a rapid assessment algorithm based on high-sensitivity cardiac troponin sampling at 0 1 hour. Emergency physicians require high sensitivity confidently AMI, whereas cardiologists aim minimize false-positive results. Methods: High-sensitivity I T assays were used measure concentrations patients presenting with chest-pain symptoms being...
<h3>Objective</h3> International guidelines to rule-in acute myocardial infarction (AMI) in patients presenting with chest pain the emergency department (ED) recommend an algorithm using high-sensitivity cardiac troponin (hs-cTn) sampling on presentation and 3 h following presentation. We tested diagnostic accuracy of this by pooling data from five distinct cohorts three countries prospectively recruited independently adjudicated outcomes. <h3>Method</h3> measured I (hs-cTnI) T (hs-cTnT) (0...
Abstract The International Federation of Clinical Chemistry Committee on Application Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization cardiac biomarkers in clinical laboratories practice. committee’s goals are improve the understanding certain key analytical aspects how these may interplay Measurement high-sensitivity troponin (hs-cTn) assays is a cornerstone evaluation patients with symptoms and/or signs acute ischemia....
Abstract Objectives Clinical practice guidelines endorse the stratification of prostate cancer (PCa) risk according to individual total prostate-specific antigen (tPSA) values and age enhance risk-benefit ratio. We defined two nomograms predict high low grade PCa by combining assay tPSA %free/tPSA (%f/tPSA) in patients with a pre-biopsy between 2 10 μg/L. Methods The study cohort consisted 662 that had fPSA, tPSA, biopsy performed (41.3% final diagnosis PCa). Logistic regression including...
Past investigations regarding the utility of high-sensitivity cardiac troponin I (cTnI) assays have been focused primarily on acute coronary syndrome setting. We assessed whether such can predict future ischemic cardiovascular events in a stable high-risk population.We quantified serum cTnI using an investigational assay (hs-cTnI IUO, Beckman Coulter) 2572 participants from Heart Outcomes Prevention Evaluation (HOPE) study. The derived ROC curve cutoff and 99th percentile for hs-cTnI were by...
Clinical AKI, measured by serum creatinine elevation, is associated with long-term risks of adverse cardiovascular (CV) events and mortality in patients after cardiac surgery. To evaluate the relative contributions urine kidney injury biomarkers plasma events, we conducted a multicenter prospective cohort study 968 adults undergoing On postoperative days 1-3, five (IL-18, NGAL, KIM-1, L-FABP, albumin) (NT-proBNP, H-FABP, hs-cTnT, cTnI, CK-MB). The primary outcome was composite CV or death,...