A5101933322- Renal cell carcinoma treatment
- Renal and related cancers
- Atrial Fibrillation Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Cardiac Arrhythmias and Treatments
- Epigenetics and DNA Methylation
- Schizophrenia research and treatment
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- BRCA gene mutations in cancer
- Iron Metabolism and Disorders
- Genetic factors in colorectal cancer
- Genetic and Kidney Cyst Diseases
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Prenatal Screening and Diagnostics
- Cancer Cells and Metastasis
- Tryptophan and brain disorders
- Cardiac electrophysiology and arrhythmias
- Lymphatic System and Diseases
- Viral gastroenteritis research and epidemiology
- Bone health and treatments
- Neonatal Health and Biochemistry
Shanghai Chest Hospital
2018-2024
West China Hospital of Sichuan University
2021-2024
Central South University
2014-2024
Shanghai Jiao Tong University
2013-2024
Guangzhou Medical University
2024
Second Xiangya Hospital of Central South University
2016-2024
Sichuan University
2021-2024
Inner Mongolia Medical University
2024
Nanjing University
2014-2022
Second Military Medical University
2017-2022
Weight gain, a common adverse effect of antipsychotic medications, is associated with medical comorbidities in psychiatric patients.To test the efficacy lifestyle intervention and metformin alone combination for antipsychotic-induced weight gain abnormalities insulin sensitivity.A randomized controlled trial (October 2004-December 2006) involving 128 adult patients schizophrenia Mental Health Institute Second Xiangya Hospital, Central South University, China. Participants who gained more...
Sentinel lymph node (SLN) metastasis is the first step in spreading of cancer many malignancies. Tumor-reactive lymphadenopathy SLNs has been observed for decades, but alterations lymphatic channels and vasculature these nodes before arrival metastatic tumor cells remain unexplored. Using animal models, we show here that, establishment SLN, there are reorganizations vasculature. The becomes a functional blood vessel-enriched vessel/sinus-enriched organ metastasis. enlargement sinuses...
Objective: The purpose of this study was to assess the efficacy metformin in preventing olanzapine-induced weight gain. Method: Forty patients with schizophrenia were randomly assigned treatment for 12 weeks olanzapine, 15 mg/day, plus metformin, 750 mg/day (N=20), or placebo (N=20). This investigation conducted a double-blind fashion. Planned assessments included body weight, mass index, proportion who gained more than 7% their baseline at end 12-week treatment, waist circumference,...
The Birt-Hogg-Dubé (BHD) disease is a genetic cancer syndrome. responsible gene, BHD, has been identified by positional cloning and thought to be novel tumor suppressor gene. BHD mutations cause many types of diseases including renal cell carcinomas, fibrofolliculomas, spontaneous pneumothorax, lung cysts, colonic polyps/cancers. By combining Gateway Technology with the Ksp-Cre gene knockout system, we have developed kidney-specific mouse model. BHD(flox/flox)/Ksp-Cre mice enlarged kidneys...
Context: Antipsychotic drugs are limited in their ability to improve the overall outcome of schizophrenia.Adding psychosocial treatment may produce greater improvement functional than does medication alone.Objective: To evaluate effectiveness antipsychotic alone vs combined with intervention on outcomes early-stage schizophrenia.Design: Randomized controlled trial.Setting: Ten clinical sites China.Participants: Clinical sample 1268 patients earlystage schizophrenia treated from January 1,...
Abstract Papillary renal cell carcinoma (RCC) represents 10% to 15% of adult neoplasms; however, the molecular genetic events that are associated with development and progression sporadic papillary RCC remain largely unclear. RCCs can be divided into two subtypes based on histologic, cytogenetic, gene expression differences. Type 1 tumors (∼60–70%) generally low grade favorable outcome, whereas type 2 (∼30–40%) increased cytogenetic complexity, high tumor grade, poor prognosis. In this...
Parafibromin, a transcription factor associated with the PAF complex, is encoded by HRPT2 gene, mutations of which cause hyperparathyroidism-jaw tumor syndrome (OMIM145001).To elucidate function parafibromin, we generated conventional and conditional Hrpt2 knockout mice found that ؊/؊ were embryonic lethal day 6.5 (E6.5).Controlled deletion after E8.5 resulted in apoptosis growth retardation.Deletion adult led to severe cachexia death within 20 days.To explore mechanism underlying lethality...
Abstract Background Germline mutations in the folliculin ( FLCN ) gene are associated with development of Birt-Hogg-Dubé syndrome (BHDS), a disease characterized by papular skin lesions, high occurrence spontaneous pneumothorax, and renal neoplasias. The majority tumors that arise BHDS-affected individuals histologically similar to sporadic chromophobe cell carcinoma (RCC) oncocytoma. However, most lack extent which BHDS-derived share genetic defects has not been well studied. Methods BHDS...
Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on set human tumors this type and identified phosphatidylinositol 3-kinase (PI3K)/AKT activation signature in 76.9% (n = 13) our samples. Sequence analysis found both activating mutations PIK3CA (13.6%, n 22) loss heterozygosity at PTEN locus (25%, 8). In contrast, none other subtypes kidney neoplasms (e.g., clear-cell cell carcinoma) harbored 87; P <...
In Brief Study Design. We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study histopathological features and connective tissue growth factor (CTGF) expressions. Objective. To expression role CTGF in fibrosis degeneration painful disc tissue. Summary Background Data. Previous studies have demonstrated that degenerative commonly showed histology. CTGF, a downstream effector mediated by transforming factor–β1 (TGF-β1), is related...
Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity paclitaxel to FLCN-deficient kidney cell line, UOK257. In this report, we investigate the cellular and molecular mechanism paclitaxel-induced autophagy renal cells with without FLCN expression. Two pairs lines were used: siRNA-silenced ACHN line (ACHN-5968) scrambled (ACHN-sc); FLCN-null UOK257 UOK257-2 restored ectopic expression FLCN. Autophagy...
Thalassemia is a common monogenic disease in southwestern China, especially Guizhou province. In this study, 18 309 neonates were examined for thalassemia. The thalassemia carrier rate was 12.90%, which associated with geographical regions, frequencies significantly differing between regions (p < 0.0001). rates α-thalassemia and β-thalassemia 8.91% 3.36%, respectively. There are 22 genotypes identified among 1632 cases, detected 615 cases. birthrates of individuals intermediate major 0.153%...
Background: The key active component(s) in an anti-tumor preparation used traditional Chinese medicine, Xihuang Pills, remains unclear. Methods: We a network pharmacology analysis to construct component-disease-target diagram and this determine quercetin as critical ingredient Pills. Subsequently, human hepatocellular carcinoma (HCC) cell lines, H22 HepG2 cells, were treated with quercetin, BALB/c mice injected cells different concentrations of quercetin. Tumor volume weight determined these...