A5102710453- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- RNA Research and Splicing
- Immune cells in cancer
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- HVDC Systems and Fault Protection
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
Hunan University of Traditional Chinese Medicine
2020-2023
Objective: The use of immune checkpoint inhibitors (ICIs) provides promising strategies for hepatocellular carcinoma (HCC) treatment. This study aimed to explore impact and underlying mechanism the combination therapy quercetin anti-programmed cell death 1 (anti-PD-1) antibody on HCC. Methods: Orthotopically transplanted HCC tumors in mice were treated with quercetin, anti-PD-1 antibody, or a both therapies. Histopathological changes programmed ligand (PD-L1) expression characterized by...
LncRNA plays a pivotal role in the stemness and drug resistance of lung cancer. Here, we found that lncRNA-AC026356.1 was upregulated stem spheres chemo-resistant cancer cells. Our fish assay also shows AC026356.1 predominantly located cytoplasm cells does not have protein-coding potential. Silencing significantly inhibited proliferation migration but increased apoptosis A549-cisplatin (DDP) Additionally, IGF2BP2 positively regulated stem-like Further mechanistic investigation revealed...
Background: The key active component(s) in an anti-tumor preparation used traditional Chinese medicine, Xihuang Pills, remains unclear. Methods: We a network pharmacology analysis to construct component-disease-target diagram and this determine quercetin as critical ingredient Pills. Subsequently, human hepatocellular carcinoma (HCC) cell lines, H22 HepG2 cells, were treated with quercetin, BALB/c mice injected cells different concentrations of quercetin. Tumor volume weight determined these...
Background: Nasopharyngeal carcinoma (NPC) is a usual head and neck malignancy. Guggulsterone (GS) has potential in cancer chemoprophylaxis treatment, but its therapeutic effect on NPC unknown. We aimed to explore whether GS could promote the secretion of exosomal circFIP1L1 from cells regulatory mechanism. Methods: tissues adjacent were collected patients. Human nasopharyngeal epithelial cell lines (NP69) (5-8F, CNE1, HNE1) used for vitro experiments. HNE1 treated with (20, 40, 60 μmol/L)....
Calculus Bovis (CB) has been employed to treat diseases for a long time. It identified play significant anti-inflammatory and anti-tumor roles. However, the mechanism of treating primary liver cancer (PLC) remains be revealed. This study aims clarify molecules mechanisms CB in PLC.After oral bioavailability (OB) drug-likeness (DL) screening, 15 small were as potential ingredients against PLC. Following this, related targets network constructions pathways applied An vitro experiment was...
Lung adenocarcinoma (LUAD) cells could escape from the monitoring of immune and metastasize rapidly through escape. Therefore, we aimed to develop a method predict prognosis LUAD patients based on checkpoints their associated genes, thus providing guidance for treatment. Gene sequencing data were downloaded Cancer Genome Atlas (TCGA) analyzed by R software Bioconductor package. Based checkpoint kmdist clustering in ConsensusClusterPlus package was utilized classify LUAD. CIBERSORT used...
Cisplatin (CDDP) has been successfully used in chemotherapy for liver cancer. However, the development of CDDP resistance HepG2 cells usually leads to relapse and a worsening prognosis. MiR-340-5p attracted much attention because its ability affect cell resistance. This project is intended explore role miR-340-5p CDK6 CDDP-R provide new ideas treatment A dual-luciferase reporter assay was confirm targeting relationship between CDK6. We constructed CDDP-resistant model examine effect on drug...