A5070737489- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Bioenergy crop production and management
- Plant responses to water stress
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Plant Pathogens and Resistance
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
- Plant Reproductive Biology
- Photosynthetic Processes and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Curcumin's Biomedical Applications
- Plant tissue culture and regeneration
- Cancer Immunotherapy and Biomarkers
- GABA and Rice Research
- Plant-Microbe Interactions and Immunity
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
Institute of Genetics and Developmental Biology
2010-2025
Chinese Academy of Sciences
2010-2025
University of South China
2007-2025
State Key Laboratory of Plant Genomics
2010-2024
Second People Hospital of Hunan
2023
Hunan Institute of Mental Health
2020
Institute of Botany
2018
First Affiliated Hospital of University of South China
2007-2017
Tufts University
2016-2017
United States Department of Agriculture
2016
Seed dormancy is an important economic trait for agricultural production. Abscisic acid (ABA) and Gibberellins (GA) are the primary factors that regulate transition from to germination, they this process antagonistically. The detailed regulatory mechanism involving crosstalk between ABA GA, which underlies seed dormancy, requires further elucidation. Here, we report ABI4 positively regulates while negatively regulating cotyledon greening, by mediating biogenesis of GA. Seeds Arabidopsis abi4...
Abstract Plants modify their growth and development to protect themselves from detrimental conditions by triggering a variety of signaling pathways, including the activation ubiquitin-mediated protein degradation pathway. Endoplasmic reticulum (ER)-associated (ERAD) is an important aspect ubiquitin-proteasome system, but only few active ERAD components have been reported in plants. Here, we report that Arabidopsis thaliana ubiquitin-conjugating enzyme, UBC32, stress-induced functional...
The use of alkaline salt lands for crop production is hindered by a scarcity knowledge and breeding efforts plant tolerance. Through genome association analysis sorghum, naturally high-alkaline-tolerant crop, we detected major locus, Alkaline Tolerance 1 (AT1), specifically related to alkaline-salinity sensitivity. An at1 allele with carboxyl-terminal truncation increased sensitivity, whereas knockout AT1 tolerance alkalinity in millet, rice, maize. encodes an atypical G protein γ subunit...
Abscisic acid (ABA) and gibberellins (GAs) are plant hormones which antagonistically mediate numerous physiological processes, their optimal balance is essential for normal development. However, the molecular mechanism underlying ABA GA antagonism still needs to be determined. Here, we report that ABA-INSENSITIVE 4 (ABI4) a central factor in GA/ABA homeostasis post-germination stages. ABI4 overexpression Arabidopsis (OE-ABI4) leads developmental defects including decrease height poor seed...
Abstract The plant hormone abscisic acid (ABA) regulates many aspects of development and the stress response. intracellular E3 ligase SDIR1 (SALT- AND DROUGHT-INDUCED REALLY INTERESTING NEW GENE FINGER1) plays a key role in ABA signaling, regulating ABA-related seed germination In this study, we found that is localized on endoplasmic reticulum membrane Arabidopsis thaliana. Using cell biology, molecular biochemistry approaches, demonstrated interacts with ubiquitinates its substrate, SDIRIP1...
During the life cycle of a plant, one major biological processes is transition from vegetative to reproductive stage. In Arabidopsis, flowering time precisely controlled by extensive environmental and internal cues. Gibberellins (GAs) promote flowering, while abscisic acid (ABA) considered as suppressor. However, detailed mechanism through which ABA inhibits floral poorly understood. Here, we report that ABSCISIC ACID-INSENSITIVE 4 (ABI4), key component in signalling pathway, negatively...
Significance Auxin signaling components participate in ethylene-mediated inhibition of root elongation. However, the interplay between TIR1/AFB2-auxin-Aux/indole acetic acid (IAA) and ethylene response remains to be elucidated detail. In this study, we report an E3 ubiquitin ligase soil-surface rooting 1 (SOR1), which targets a noncanonical Aux/IAA protein OsIAA26 for 26S proteasome-mediated degradation. The activity SOR1 can repressed by canonical OsIAA9, is target OsTIR1/AFB2. Our study...
Early epidemiologic studies have reported that tobacco smoking, which is causally associated with liver cancer, an independent risk factor for non‐alcoholic fatty diseases (NAFLD). Lycopene from tomatoes has been shown to be a potential preventive agent against NAFLD and hepatocellular carcinoma (HCC). In the present study, we investigated whether carcinogen 4‐( N ‐methyl‐ ‐nitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) induces lesions in both lungs livers of ferrets or without lycopene...
Sorghum, the fifth largest cereal crop, has high value as a staple food and raw material for liquor vinegar brewing. Due to its biomass quality, it is also used second most planted silage resource. No fragrant sorghums are currently on market. Through CRISPR/Cas9-mediated knockout of SbBADH2, we obtained sorghum lines with extraordinary aromatic smell in both seeds leaves. Animal feeding experiments showed that leaves were attractable. We believe this advantage will produce great market...
Abstract One of the most critical steps in cereal threshing is ease with which seeds are detached from sticky glumes. Naked grains low glume coverage have dramatically increased efficiency and seed quality. Here, we demonstrate that GC1 ( Glume Coverage 1 ), encoding an atypical G protein γ subunit, negatively regulates sorghum coverage. Naturally truncated variations C-terminus accumulate at higher levels affect stability a patatin-related phospholipase SbpPLAII-1. A strong positive...
Summary Powdery mildew is one of the most devastating wheat fungal diseases. A diploid relative, Haynaldia villosa L., highly resistant to powdery mildew, and its genetic resource resistances, such as Pm21 locus, now widely used in breeding. Here we report cloning a resistance gene from H. , designated CMPG 1–V that encodes U–box E3 ubiquitin ligase. Expression was induced leaf stem upon inoculation with Blumeria graminis f. sp. tritici ( Bgt ) fungus, presence essential for rapid induction...
Abstract Background Gastric cancer (GC) is a malignant tumour originating from the gastric mucosa epithelium that seriously threatens human health. DCLK1, miR-15b and lncRNA SNHG1 play potential roles in occurrence of GC, but mechanism remains unclear. Methods Gene expression was investigated by qRT-PCR. Protein detected Western blotting. Migration invasion cells tested Transwell assay wound healing assay. Cell proliferation measured an MTT Finally, correctness prediction results confirmed...
Sweet sorghum is a C4 crop that can be grown for silage forage, fiber, syrup and fuel production. It generally considered salt-tolerant plant. However, the salt tolerance ability varies among genotypes, mechanism not well known. To further uncover mechanism, we performed comparative transcriptome analysis with RNA samples in two sweet genotypes showing different abilities (salt-tolerant line RIO salt-sensitive SN005) upon treatment. These response processes mainly focused on secondary...
3152 Background: This study aimed to evaluate the efficacy and safety of drug-loaded vesicle (DLV) intrapleural perfusion combined with systemic therapy in patients lung or breast cancer malignant pleural effusion (MPE). Methods: multicenter, randomized, controlled, open-label clinical trial included pathologically confirmed MPE requiring thoracentesis. In total, 96 were randomised 1:1 arm 1 receiving DLV (50 mL daily for four consecutive days) plus (ST) 2 interleukin-2 (IL-2) every three...
High-fat diets (HFDs) and excess adiposity increase proinflammatory cytokines in the colon, altering gene expression a manner that promotes development of colorectal cancer (CRC). Thus, compounds reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), dietary polyphenol, salsalate (SAL), non-steroidal anti-inflammatory drug, both anti-inflammatories. We investigated inhibitory effects CUR with or without SAL on inflammatory procarcinogenic signaling...
Nasopharyngeal carcinoma (NPC) is a rare head and neck tumor that threatens people's health. Radiotherapy major treatment for NPC, however, radioresistance of the NPC cells may contribute to failure. LncRNA SNHG16 was upregulated in NPC; function radioresistant remains unexplored. RT-qPCR applied detecting SNHG16, miR-31-5p SFN levels. MTT assay colony formation were assess cell viability proliferation. Dual luciferase assessing relation among SFN. level examined by Western blot. The...