A5100624688- Hippo pathway signaling and YAP/TAZ
- Retinal Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Glaucoma and retinal disorders
- Intracranial Aneurysms: Treatment and Complications
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Retinal Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Medical Image Segmentation Techniques
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Surface Modification and Superhydrophobicity
- Cerebrovascular and Carotid Artery Diseases
- Tea Polyphenols and Effects
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Pelvic and Acetabular Injuries
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
Anhui Science and Technology University
2025
Anhui University of Science and Technology
2025
Liaoning Normal University
2025
Huaian First People’s Hospital
2025
East China University of Science and Technology
2017-2024
Zhejiang University
2024
Shaanxi University of Chinese Medicine
2021-2024
Southwest Jiaotong University
2024
Anhui Medical University
2023-2024
Southern Medical University
2008-2024
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor kinase MST1/2 provides therapeutic option for tissue injury repair.
Abstract Real‐time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for development biomaterial‐guided on‐site technology. In this study, multifunctional double colorimetry‐integrated polyacrylamide‐quaternary ammonium chitosan‐carbon quantum dots (CQDs)‐phenol red hydrogels are presented, aiming to simultaneously detect pH level, reduce bacterial infection, and promote healing. The hybridization CQDs indicator (phenol red) with enables...
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss Mst1/2, mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably enlarged endoplasmic reticulum (ER) size-associated UPR. Intriguingly, attenuation UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis promoting nuclear exit degradation downstream effector Yap. Yap is required for activity ER expansion...
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to promoter activates YAP transcription. depletion of downregulates YAP, resulting a G1/S cell-cycle block increased cell death, both which are substantially rescued by reconstituting YAP. can be inactivated oxidative mechanisms, acetaminophen-induced...
Tumor-associated macrophages (TAMs), one of the dominating constituents tumor microenvironment, are important contributors to cancer progression and treatment resistance. Therefore, regulation TAMs polarization from M2 phenotype towards M1 has emerged as a new strategy for immunotherapy. Herein, we successfully initiated antitumor immunotherapy by inhibiting via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles (PEG-AuNPs). PEG-AuNPs suppressed in both vitro vivo...
Injectable materials show their special merits in regeneration of damaged/degenerated bones minimally-invasive approach. calcium phosphate bone cement (CPC) has attracted broad attention for its bioactivity, as compared to non-degradable polymethyl methacrylate cement. However, brittleness, poor anti-washout property and uncontrollable biodegradability are the main challenges limit further clinical application mainly because stone-like dense structure fragile inorganic-salt weakness. Herein,...
The application of gelatin hydrogels is hampered by their poor mechanical properties, which are unfavorable for debridement and diabetic wound healing. Herein, bovine serum albumin (BSA)-bridged biopotentiated bone marrow mesenchymal stem cell (BMSC)-derived nanovesicles (NV), named [email protected], were fabricated reinforcement with genipin BSA in a one-pot, low-cost green approach based on amide bonding-guided crosslinking. Genipin introduction endowed the crosslinking weak properties...
Facing the high incidence of skin diseases, it is urgent to develop functional materials with bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in healing process mainly
Many artificial intelligence (AI) studies have focused on development of AI models, novel techniques, and reporting guidelines. However, little is understood about clinicians' perspectives applications in medical fields including ophthalmology, particularly light recent regulatory The aim for this study was to evaluate the ophthalmologists regarding 4 major eye conditions: diabetic retinopathy (DR), glaucoma, age-related macular degeneration (AMD) cataract.This a multi-national survey...
The treatment of osteoporotic bone defect remains a big clinical challenge because osteoporosis (OP) is associated with oxidative stress and high levels reactive oxygen species (ROS), condition detrimental for formation. Anti-oxidative nanomaterials such as selenium nanoparticles (SeNPs) have positive effect on osteogenesis owing to their pleiotropic pharmacological activity which can exert anti-oxidative functions prevent loss facilitate regeneration in OP. In the current study strategy...