Xun� Li

ORCID: 0000-0001-6862-7692
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About
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Research Areas
  • Kidney Stones and Urolithiasis Treatments
  • Gallbladder and Bile Duct Disorders
  • Pediatric Urology and Nephrology Studies
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pancreatic and Hepatic Oncology Research
  • Liver Disease Diagnosis and Treatment
  • RNA modifications and cancer
  • Liver Disease and Transplantation
  • Heavy Metal Exposure and Toxicity
  • Liver physiology and pathology
  • Cancer-related molecular mechanisms research
  • Esophageal and GI Pathology
  • MicroRNA in disease regulation
  • SARS-CoV-2 and COVID-19 Research
  • Extracellular vesicles in disease
  • Pancreatitis Pathology and Treatment
  • Ureteral procedures and complications
  • Gut microbiota and health
  • Organ Transplantation Techniques and Outcomes
  • COVID-19 Clinical Research Studies
  • Paleopathology and ancient diseases
  • Helicobacter pylori-related gastroenterology studies
  • Trace Elements in Health
  • Biliary and Gastrointestinal Fistulas

First Hospital of Lanzhou University
2015-2024

Lanzhou University
2015-2024

Guangzhou Medical University
2009-2024

Tianjin Huanhu Hospital
2023-2024

First Affiliated Hospital of Xiamen University
2019-2024

First Affiliated Hospital of Chengdu Medical College
2024

Eastern Hepatobiliary Surgery Hospital
2017-2024

Second Military Medical University
2017-2024

Shandong Sport University
2022-2024

Northwest Normal University
2024

Abstract Evidence for the involvement of N 6 -Methyladenosine (m A) modification in etiology and progression liver fibrosis has emerged holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) mRNA-binding protein (IGF2BP2) is newly identified m A-binding that functions to enhance mRNA stability translation. However, its role an remains elusive. Here, we observed IGF2BP2 highly expressed activated hepatic stellate cells (HSCs), inhibition protects against HSCs activation...

10.1038/s41419-024-06509-9 article EN cc-by Cell Death and Disease 2024-03-05

Objective: High renal pelvic pressure brings systemic absorption of irrigation fluid containing bacteria or endotoxins, which leads to postoperative fever. We inspected the (RPP) in vivo during minimally invasive percutaneous nephrolithotomy (MPCNL) investigate whether a 14- 18-French tract and perfusion would bring high RPP

10.1089/end.2008.0001 article EN Journal of Endourology 2008-09-01

Background: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about clinical characteristics of patients with SARS-CoV-2 infection high-altitude region China. We reported disease 2019 (COVID-19) Gansu province, Methods: In this retrospective study, laboratory-confirmed were consecutively enrolled from January 21, 2020 to February 11, 2020. information on epidemiological, characteristics, laboratory tests,...

10.21037/apm-20-887 article EN Annals of Palliative Medicine 2020-07-01

The programmed death-1 (PD-1)/B7-H1 pathway acts as an important negative regulator of immune responses. We herein investigated the role PD-1/B7-H1 in establishing immunological spontaneous tolerance status mouse liver allografting. B7-H1 is highly expressed on donor-derived tissue cells and it also associated with apoptosis infiltrating T allografts. Strikingly, a blockade via anti-B7-H1mAb or using knockout mice donor led to severe cell infiltration well hemorrhaging necrosis, thus...

10.1111/j.1600-6143.2009.02859.x article EN cc-by-nc-nd American Journal of Transplantation 2009-11-04

Transfer of noncoding microRNAs (miRNAs) by extracellular vesicles (EVs) promotes the development chemoresistance in many tumor types. Additionally, restoration or depletion several miRNAs has been observed multiple cancer types including gastric (GC). In this present study, we aimed to investigate mechanism miR-130b-3p M2 macrophage-derived EVs GC through regulation mixed lineage leukemia 3 (MLL3) and grainyhead-like 2 (GRHL2).Expression GRHL2 was quantified 63 pairs cancerous noncancerous...

10.1186/s13046-020-01626-7 article EN cc-by Journal of Experimental & Clinical Cancer Research 2020-07-13
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