A5100408789- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Acute Ischemic Stroke Management
- Cancer Research and Treatments
- Pancreatic function and diabetes
- Cerebrovascular and Carotid Artery Diseases
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Metal complexes synthesis and properties
- Virus-based gene therapy research
- Congenital gastrointestinal and neural anomalies
- Acute Kidney Injury Research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
Chengdu University of Traditional Chinese Medicine
2024
Mianyang Central Hospital
2021-2024
Qilu Hospital of Shandong University
2013-2024
Guangzhou University of Chinese Medicine
2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
China Medical University
2018-2024
First Hospital of China Medical University
2018-2024
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma ( RCC ). Tumor‐infiltrating immune cells TIIC s) regulate cancer progression and are appealing therapeutic targets. The purpose this study was to determine the composition s further reveal independent prognostic values s. CIBERSORT , an established algorithm, applied estimate proportions 22 types based on gene expression profiles 891 tumors. Cox regression used evaluate association checkpoint...
Long noncoding RNAs (lncRNAs), a recently discovered class of cellular RNAs, play important roles in the regulation many developmental processes. Although lncRNAs have been systematically identified various systems, most them not functionally characterized vivo animal models. In this study, we 128 testis-specific Drosophila and knocked out 105 using an optimized three-component CRISPR/Cas9 system. Among lncRNA knockouts, 33 (31%) exhibited partial or complete loss male fertility, accompanied...
Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial the mechanisms underlying these remain largely unknown. This study aimed to investigate potential relationship between regulation by dietary alterations gut microbiota in obese diabetic ob/ob mice. Methods: mice were subjected a normal, low-capsaicin (0.01%), or high-capsaicin (0.02%) diet for 6 weeks, respectively. Obesity phenotypes, homeostasis, structure composition, short-chain fatty acids,...
Abstract Knowledge about the impact of altitude and ethnicity on human gut microbiota is currently limited. In this study, fecal from 12 Tibetans (T group), 11 Chinese Han living in Tibet (HH group) Shaanxi province (LH were profiled by 454 pyrosequencing. Analysis UniFrac principal coordinates showed significant structural changes among three groups. There differences composition groups at phylum genus levels. At level, samples HH T had higher relative abundances Firmicutes , whereas LH...
Accumulating data indicated that circRNA plays important roles in regulating many biological processes of the tumor, present study is designated for exploring circ-ZEB1.33-miR-200a-3p-CDK6 axis human hepatocellular carcinoma (HCC).The regulation as predicted by using online tool circNet, expression and correlation was verified HCC. The diagnostic value both tumor serum circ-ZEB1.33 estimated clinical samples. cell cycle were explored vitro studies.Overexpression CDK6, downregulation...
Background: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about clinical characteristics of patients with SARS-CoV-2 infection high-altitude region China. We reported disease 2019 (COVID-19) Gansu province, Methods: In this retrospective study, laboratory-confirmed were consecutively enrolled from January 21, 2020 to February 11, 2020. information on epidemiological, characteristics, laboratory tests,...
Objective . This study was to screen for the miRNAs differently expressed in peripheral blood mononuclear cells (PBMC) of RA, further identify expression miR-155 RA PBMC and fibroblast-like synoviocytes (FLS), evaluate function RA-FLS. Methods Microarray used differentially PBMC. FLS were identified by real-time PCR. Enforced overexpression downexpression investigate Expression IKBKE which previously as actual target examined Western blot PCR Results levels increased both could be induced...
Salmonella infections in newly hatched chicks result enteric and systemic diseases with a high mortality. Probiotics can improve the health of host. The purpose present study was to investigate effect Lactobacillus plantarum LTC-113 on gut permeability presence or absence (Salmonella Typhimurium) infection. Newly were randomly allocated 4 treatments (i) NC (negative control); (ii) LAC (the L. LTC-113-treated group); (iii) SAL Salmonella-infected group), (iv) + group). Compared group,...
In this study, we first revealed a novel role of cGAS in the regulation pathological cardiac remodeling and dysfunction upon pressure overload. We found that cGAS/STING pathway was activated during Moreover, also demonstrated inhibition alleviated downregulated early inflammatory response overload-induced HF. Together, these findings will provide new therapeutic target for
// Tiemin Pei 1, * , Qinghui Meng Jihua Han Haobo Sun 1 Long Li Ruipeng Song Boshi Shangha Pan Desen Liang Lianxin Liu Key Laboratory of Hepatosplenic Surgery, Ministry Education, Department General the First Affiliated Hospital Harbin Medical University, Harbin, China These authors contributed equally to this work Correspondence to: Liu, email: liulx@ems.hrbmu.edu.cn Liang, liangdesen2015@163.com Keywords: hepatocellular carcinoma, (-)-Oleocanthal, tumor growth, metastasis, STAT3 Received:...
BackgroundGlioma is the most common primary malignant tumor in central nervous system with frequent hypoxia and angiogenesis. Limb-Bud Heart (LBH) a highly conserved transcription cofactor that participates embryonic development tumorigenesis.MethodsThe conditioned media from LBH regulated human glioma cell lines patient-derived stem cells (GSCs) were used to treat brain microvessel endothelial (hBMECs). The function of on angiogenesis examined through methods MTS assay, Edu TUNEL western...
BackgroundAs a neurotrophic factor, prosaposin (PSAP) can exert neuroprotective and effects. It is involved in the occurrence development of prostate breast cancer. However, there no research about role PSAP glioma.MethodsThe overexpressed or silenced glioma cells stem were established based on Lentiviral vector transfection. Cell viability assay, Edu neurosphere formation assay xenograft experiments used to detect proliferative ability. Western blot, Elisa luciferase reporter assays...
Abstract This study aimed to evaluate the protective effect of hydroxysafflor yellow A (HSYA) on ischemia/reperfusion (I/R)-induced acute kidney injury via TLR4/NF-κB pathway, both in vitro and vivo . Rats were subjected removal right I/R left kidney. renal treated with HSYA at 0.5 h prior injury. Renal function, histopathological analysis, cells apoptosis measured vivo. In , proximal tubular (HK-2) hypoxia/reoxygenation (H/R). Apoptotic cell death inflammatory cytokines, Toll-like receptor...
Cervical cancer (CC) is a major health threat to women worldwide. Long non-coding RNA (lncRNA) has been reported play crucial roles in regulating carcinogenesis, including CC.In this work, levels of lncRNA forkhead box P4 antisense 1 (FOXP4-AS1) CC cell lines and normal were analyzed with quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) method. Effects FOXP4-AS1 on cellular behaviors proliferation, migration, invasion explored. Bioinformatic prediction tools luciferase activity...
Abstract Background/Aims Evidence has shown that several microRNAs (miRNAs) may be involved in coronary plaque rupture and local thrombus. However, the diagnostic ability of these miRNAs acute myocardial infarction (AMI) is less known. The aim this study to explore value circulating patients presenting with chest pain emergency department. Methods results In a nested case–control study, 140 1,206 finally diagnosed AMI were matched 70 unstable angina noncardiac patients. Five candidate...
Abstract Over the last decade, more than 10 independent SNPs have been discovered to be associated with risk of renal cell carcinoma among different populations. However, biological functions them remain poorly understood. In this study, we performed eQTL analysis, ChIP-PCR, luciferase reporter assay, and Cox regression analysis identify functional role underlying mechanism rs67311347 in RCC. The ENCORI database, which contains lncRNA–miRNA–mRNA interactions, was used explore possible target...
Data are limited on the prevalence and vascular distribution of multiterritorial atherosclerotic plaque stenosis in community populations.To investigate older, community-dwelling populations China.This cross-sectional study was based baseline survey from Polyvascular Evaluation for Cognitive Impairment Vascular Events (PRECISE) study, a population-based prospective cohort that enrolled adults aged 50 to 75 years cluster sampling 6 villages 4 living communities Lishui city southeast China....
Mounting evidence has linked both obesity and metabolic disorders with dysbiosis of the gut microbiota. Dietary inulin is conducive to modulating this dysbiosis, represents a potential means improve glucose lipid metabolism. However, mechanisms underlying these improvements are largely unclear. Obese ob/ob mice were fed standard chow, low fiber diet (LFD) or high (HFD) for 4 weeks, body weight, fecal short chain fatty acids (SCFAs) level, plasma liver profiles analyzed. Oral tolerance...