A5017839135- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Breast Lesions and Carcinomas
- Cervical Cancer and HPV Research
- Plant Disease Resistance and Genetics
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Mindfulness and Compassion Interventions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- melanin and skin pigmentation
- COVID-19 and Mental Health
- PI3K/AKT/mTOR signaling in cancer
Jilin University
2015-2024
Nanjing Medical University
2013-2024
State Key Laboratory of Reproductive Medicine
2024
First Hospital of Jilin University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Peking Union Medical College Hospital
2017-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Weatherford College
2024
Yangtze University
2024
Accumulating data indicated that circRNA plays important roles in regulating many biological processes of the tumor, present study is designated for exploring circ-ZEB1.33-miR-200a-3p-CDK6 axis human hepatocellular carcinoma (HCC).The regulation as predicted by using online tool circNet, expression and correlation was verified HCC. The diagnostic value both tumor serum circ-ZEB1.33 estimated clinical samples. cell cycle were explored vitro studies.Overexpression CDK6, downregulation...
Summary Drought resistance (DR) is a complex trait that regulated by variety of genes. Without comprehensive profiling DR‐related traits, the knowledge genetic architecture for DR in cotton remains limited. Thus, there need to bridge gap between genomics and phenomics. In this study, an automatic phenotyping platform (APP) was systematically applied examine 119 image‐based digital traits (i‐traits) during drought stress at seedling stage, across natural population 200 representative upland...
Abstract This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in Chinese cohort. We prospectively analyzed IgG4-RD patients recruited Peking Union Medical College Hospital from January 2011 August 2018 identified diagnosed complicating malignancies. Data regarding demographics, clinical features, treatment were collected compared those age- sex-matched controls. Among 587 IgG4-RD, 17 identified. Ten...
Breast cancer displays high morbidity and mortality. Despite exerting certain effects, traditional treatments cannot eliminate every cell may kill normal cells due to inaccurate targeting. However, as a Chinese medicine, capsaicin, an active compound extracted from chili peppers, has displayed potent anticarcinogenic activities in vitro vivo, but the underlying mechanism is not completely understood. The pharmacological effects of capsaicin on tumors was evaluated MDA MB 231 breast cells....
Shell-isolated nanoparticle-enhanced Raman spectroscopy provides a powerful method for molecular examination of breast pathology enabling early detection cancer foci.
This study aimed to present evidence that miR-7 inhibited the metastasis of breast cancer stem cells (BCSCs) and elucidated mechanisms have remained unknown. The samples collected from agomir-treated, BCSC-driven tumors were subjected a protein array analyze expression profiles. A dual-luciferase reporter chromatin immunoprecipitation-PCR used validate evaluate molecular expressions interest in tissues cell lines. overexpression affecting BCSCs was further evaluated mice. endothelial...
Breast cancer is the most prevalent malignancy occurring in females. In recent years, emerging evidence has suggested that circular RNAs are involved development of multiple cancers. Circ-PRMT5 recently attracted attention as a tumor-promoting RNA. present study, we focused on exploring biological effects circ-PRMT5 breast cancer.A quantitative real-time polymerase chain reaction was used to determine expression cancer. vitro experiments, including cell-counting kit-8,...
Long noncoding RNA (lncRNA) MAF BZIP transcription factor G antisense 1 (MAFG‑AS1) has been demonstrated to serve an important role in the progression of various types cancer, whereas its breast cancer not fully elucidated. The present study aimed explore potential and underlying mechanism MAFG‑AS1 cancer. To achieve this, expression MAFG‑AS1, microRNA (miR)‑150‑5p MYB was detected by reverse transcription‑quantitative PCR. binding between miR‑150‑5p or verified using a luciferase reporter...
The thyroid gland is susceptible to chemical exposure such as organophosphate insecticides (OPIs). With the ubiquitous nature of these products, humans are simultaneously exposed a multitude chemicals. This study aimed evaluate association between an individual and mixture OPI metabolites changes in serum hormone (TH) concentrations. analyzed data were 1,434 participants from United States National Health Nutrition Examination Surveys (NHANES) cycle 2007‐2008. Generalized linear model (GLM)...
Abstract The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is convergence of numerous nerve and glial cells. Previous work showed dynamic changes GnRH-glial-capillary network eminence under different physiological conditions. Because aging rats associated with diminution responsiveness to estradiol feedback, we examined effects age treatment on these anatomical interactions. Rats were...
To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features prognosis HCC patients.A total 128 patients who received radical resection were enrolled from Wenling Maternal Child Health Care Hospital between May 2005 December 2008, tumor adjacent tissue samples collected. Expression PDK1 was detected by immunohistochemistry method. Correlation clinicopathological...
Circular RNA 0000511 (circ_0000511) has been observed to be dysregulated in breast cancer (BC). However, the functions of circ_0000511 remain unknown. The expression levels circ_0000511, ribonuclease P component H1, microRNA‑326 (miR‑326) and transcriptional co‑activator with PDZ‑binding motif (TAZ) were examined by reverse transcription‑quantitative PCR. Colony formation MTT assays conducted analyze cellular proliferative ability. apoptotic rate was assessed flow cytometry. Western blot...
Abstract Background Pucotenlimab is a novel recombinant humanized anti-PD-1 (Programmed death-1) monoclonal antibody, which belongs to the human IgG4/kappa subtype, and can selectively block binding of PD-1 with its ligands PD-L1 PD-L2. Methods In this phase 2 trial, patients locally advanced or metastatic melanoma who had failed conventional treatment (chemotherapy, targeted therapy, interferon, IL-2, et al.) were recruited. The administrated 3 mg/kg every weeks until disease progression,...
To assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.A case-control study was conducted to investigate the relation between PCOS.In this study, 335 patients PCOS 354 controls were recruited. The genotypes detected by TaqMan method.We found that genotypic frequencies rs1937845 polymorphism different subjects compared control, CT genotype being more commonly...
Sarcomatoid hepatocellular carcinoma (SHC) is a rare malignant hepatic tumor. Recurrent interventional therapies such as transcatheter arterial chemo-embolization (TACE), radiofrequency ablation (RFA), and percutaneous ethanol injection have been reported previously utilized in majority of SHC cases. To date, the exact pathogenic mechanisms underlying sarcomatoid transformation (HCC) remain unknown. In this study, we report 68-year-old female patient admitted to our hospital due discrete...
Triple-negative breast cancer (TNBC) is a common with increasing incidence and mortality in female. Increasing studies have revealed that long noncoding RNAs (lncRNAs) are novel molecules regulating tumors. Long intergenic non-protein coding RNA 1234 (LINC01234) has been demonstrated to function as an oncogene several However, the role of LINC01234 TNBC remains unelucidated. Herein, RT-qPCR showed expression was upregulated both tissues cell lines. Functionally, knockdown suppressed...
Postoperative endocrine therapy is known to reduce recurrence and mortality in patients with estrogen receptor (ER)- or progestogen (PR)-positive breast cancer. Correlates determinants of compliance among Chinese cancer are not known. The aim this study was elucidate the efficacy adherence China suggest effective improvements on adherence.We analyzed survival 1,110 eligible for 699 therapy. Kaplan-Meier curves, log-rank tests Cox proportional hazard models were used evaluate survival,...
Published data on the association between GST genes polymorphisms and male infertility risk are inconclusive. We investigated in a large sample size case-control study conducted literature-based meta-analysis of 6934 individuals. Our showed GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while GSTT1 normozoospermia azoospermia. Additionally, elevated expression levels were observed present compared genotype. In meta-analysis, increased infertility....