A5090372554- Extracellular vesicles in disease
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Microfluidic and Bio-sensing Technologies
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Nanopore and Nanochannel Transport Studies
- Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Ocular Surface and Contact Lens
- Urologic and reproductive health conditions
- Lung Cancer Research Studies
- Bacteriophages and microbial interactions
- Bone and Dental Protein Studies
- Reconstructive Surgery and Microvascular Techniques
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
First Affiliated Hospital of GuangXi Medical University
2025
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Troy Gastroenterology
2025
Guangxi Medical University
2025
Sun Yat-sen University
2018-2024
Sun Yat-sen University Cancer Center
2018-2024
State Key Laboratory of Oncology in South China
2007-2024
Peking University First Hospital
2007-2024
Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as promising biomarker source for cancer diagnosis via less invasive procedure. Quantitatively pinpointing exosome markers is appealing, yet challenging. In this study, we developed simple microfluidic approach (ExoSearch) which provides preparation blood plasma exosomes in situ, multiplexed detection using immunomagnetic beads. The ExoSearch chip offers robust, continuous-flow design...
Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles circulating nucleic acids including DNA, RNA, miRNA their therapeutic use.
3D printing-based facile microfabrication of a microfluidic culture chip integrates harvesting, antigenic modification, and photo-release surface engineered exosomes in one workflow, which enables rapid real-time production therapeutic for advancing cancer immunotherapy.
We report a microfluidic assay to select active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral particles (VPs), which were defined as intact with an accessible angiotensin-converting enzyme receptor binding domain (RBD) on the spike (S) protein, from clinical samples. Affinity selection of SARS-CoV-2 was carried out using injection molded chips, allow for high-scale production accommodate large-scale screening. The contained surface-bound aptamer directed against virus's...
Endoscopic ultrasonography-guided gastroenterostomy offers distinctive benefits in the management of malignant gastric outlet obstruction [11] [22]. When faced with unusual obstruction, endoscopist must find an appropriate place to "build a bridge" [33]. Here, we report case EUS-guided duodenojejunostomy following placement duodenal stent horizontal part.
Endovascular aneurysm repair (EVAR) is widely used to treat abdominal aortic (AAA). However, it carries the risk of complications that often require further interventions. Endograft limb occlusion (ELO), though relatively rare, significantly affects patient outcomes. This study investigates factors influencing and predicting ELO after EVAR. All patients who underwent EVAR for AAA between 2013 2023 at First Affiliated Hospital Guangxi Medical University were examined. Patients followed up...
Abstract Metastasis is the main cause of laryngeal cancer-related death; its molecular mechanism remains unknown. Here we identify protein arginine methyltransferase 5 (PRMT5) as a new metastasis-promoting factor in carcinoma, and explore underlying action regulating cancer progression. We illustrated that PRMT5 expression was positively correlated with tumor stages, lymphatic metastasis, unfavorable outcome. Functional assays revealed promoted carcinoma cell proliferation, migration,...
We present a chip-based extended nano-Coulter counter (XnCC) that can detect nanoparticles affinity-selected from biological samples with low concentration limit-of-detection surpasses existing resistive pulse sensors by 2–3 orders of magnitude. The XnCC was engineered to contain 5 in-plane pores each an effective diameter 350 nm placed in parallel and provide high detection efficiency for single particles translocating both hydrodynamically electrokinetically through these pores. fabricated...
The tumor-targeting iLIP<sub>ICG</sub> provides a promising strategy to improve the precision imaging and effective phototherapy for treatment of laryngeal carcinoma.
6044 Background: Consensus on neoadjuvant treatment strategies for resectable head and neck squamous cell carcinoma (HNSCC) is not proposed currently. Preclinical clinical findings suggested that PD-1/CTLA-4 bispecific antibodies may have synergistic anti-tumor activity. This study aimed to explore the safety activity of cadonilimab in combination with platinum-based dual-drug chemotherapy locally advanced, HNSCC. Methods: In this open-label phase II trial, eligible patients untreated HNSCC...
Contactin1 (CNTN1) has been shown to play an important role in the invasion and metastasis of several tumors; however, CNTN1 breast cancer not fully studied. The purpose this study is investigate regulating tumor growth, migration cancer. To its function, was expressed Hs578T cells. expression confirmed by western blot, immunohistochemistry real-time RT-PCR. effect overexpression on proliferation, cells assessed vitro vivo. Our results showed that promoted cell cycle progression, colony...
Neuroblastoma is the most common extracranial solid tumor in childhood which often acquires drug resistance and becomes aggressive phenotypes. The high-risk patients suffer from high mortality due to limitation of treatment strategies. ARID1A (AT-rich interactive domain-containing protein 1A), a subunit SWI/SNF complexes, considered as suppressor many cancers. aim present study was investigate effect on migration invasion neuroblastoma cells. shRNA targeting designed delivered into SK-N-SH...
To evaluate the auxiliary effectiveness of periprostatic fat thickness (PPFT) on multi-parametric magnetic resonance imaging (mp-MRI) to Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) in predicting presence prostate cancer (PCa) high-grade (HGPCa, Gleason Score ≥ 7).Overall, there were 371 patients (54.3%) with PCa 292 (42.8%) HGPCa. The mean value PPFT was 4.04 mm. Multivariate analysis revealed that age, prostatic specific antigen (PSA), volume, PI-RADS score,...
Importance: Successful needle puncture of the renal collecting system is a critical but difficult procedure in percutaneous nephrolithotomy (PCNL). Although fluoroscopy and ultrasound are standard imaging techniques to guide during PCNL, both have known limitations. Objective: To assess feasibility safety new navigation for ultrasound-guided PCNL. Design: This study employed single-center randomized controlled trial (RCT) design Conducted between May 2021 November 2021, utilized...
In this study we demonstrate that in corneal epithelium there is cell-cell contact-regulated expression of a 145-kDa glycoprotein (GP) bearing the glycan determinant Lewisx (Lex) (Galβ(1,4)[Fucα(1,3)]GlcNAc). This (Lex-GP) was expressed confluent/contact-inhibited cultures but not sparse epithelium. contrast, 135-kDa precursor, unfucosylated, lactosamine-containing glycans (Galβ1–4GlcNAcβ1-R) cultures. Immunofluorescence staining and confocal microscopy confluent revealed epithelium, Lex...
Objective To present a DDD scoring system in assessing the complexity and outcomes of retroperitoneoscopic nephron‐sparing surgery for kidney tumor. Methods We retrospectively evaluated 232 patients who underwent between January 2013 September 2017 renal Both score RENAL were used to classify tumors. The consisted maximal tumor diameter inside kidney, depth into medulla or collecting minimal distance from main vessels. Results systems significantly associated with warm ischemia time ( P =...