A5053107411- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Diabetes and associated disorders
- Renal and related cancers
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- RNA regulation and disease
- Mesenchymal stem cell research
- Land Use and Ecosystem Services
- Immune Response and Inflammation
- Hepatocellular Carcinoma Treatment and Prognosis
Hainan University
2025
Huazhong University of Science and Technology
2025
Central Hospital of Wuhan
2025
Peking University First Hospital
2013-2024
Peking University
2014-2024
Peking University Third Hospital
2024
Nanjing Agricultural University
2022-2024
University of Missouri
2024
University of California, Merced
2023
Central South University
2008-2022
Adult non-insulin requiring diabetes includes latent autoimmune of adults (LADA), distinguished from type 2 by the presence islet autoantibodies. LADA China determined characteristics Chinese LADA. This nationwide, multicenter, clinic-based cross-sectional study was conducted in 46 university-affiliated hospitals 25 cities. All 4,880 ketosis-free diabetic patients (<1 year postdiagnosis, without insulin therapy for >6 months, aged ≥30 years) had GAD antibody (GADA) and HLA-DQ genotype...
The preoperative selection of patients with intermediate-stage hepatocellular carcinoma (HCC) who are likely to have an objective response first transarterial chemoembolization (TACE) remains challenging.To develop and validate a clinical-radiomic model (CR model) for preoperatively predicting treatment TACE in HCC.A total 595 HCC were included this retrospective study. A tumoral peritumoral (10 mm) radiomic signature (TPR-signature) was constructed based on 3,404 features from 4 regions...
Sustainable development goals (SDGs) in the United Nations 2030 Agenda call for action by all nations to promote economic prosperity while protecting planet. Projection of future land-use change under SDG scenarios is a new attempt scientifically achieve SDGs. Herein, we proposed four scenario assumptions based on SDGs, including sustainable economy (ECO), grain (GRA), environment (ENV), and reference (REF) scenarios. We forecasted along Silk Road (resolution: 300 m) compared impacts urban...
To determine whether there have been any changes in the causes and management of urethral strictures China.The data from 4,764 men with stricture disease who underwent treatment at 13 medical centres China between 2005 2010 were retrospectively collected. The databases analysed for possible causes, site techniques stricture, as well strictures.The most common cause was trauma, which occurred 2,466 patients (51.76%). second iatrogenic injures, 1,643 (34.49%). to treat endourological surgery...
The incidence of lung cancer is extremely high. For treatment, the chemotherapy low, and drug resistance recurrence are frequently observed, in which hypoxic tumor microenvironments play a key role. We investigated upregulation long non-coding ribonucleic acid (lncRNA) H19 expression induction non-small cell (NSCLC) cells under conditions.We used cobaltous chloride (CoCl2) to create culture environments for A549 H1650 cells, they were divided into normoxia hypoxia groups. real-time...
Ischemia-reperfusion injury (IRI) is one of the leading causes mortality and disability worldwide. Owing to its complex pathogenesis, there still a lack effective therapeutic targets in clinical practice, exploring mechanism IRI major challenge. This study aimed explore genetic alterations leukocytes peripheral blood after ischemia-reperfusion, aiming discover new biomarkers potential targets. KAS-Seq (Kethoxal-assisted single-strand DNA sequencing) was used obtain gene expression profiles...
This retrospective cohort study was designed to examine the relationship between neutrophil-lymphocyte ratio (NLR) and 1-year risk of death in patients with acute heart failure (AHF) intensive care unit (ICU). We retrospectively analyzed 1,176 AHF from MIMIC-IV database. Cox regression used evaluate NLR mortality after adjusting for covariates. Nonlinear associations optimal cutoff values were determined using restricted cubic splines. Propensity score matching eliminate imbalances baseline...
Backgrounds Exosomes contain several types of transcripts, including long non-coding RNAs (lncRNAs), and have been shown to exert important effects in human diseases. However, the roles exosomal lncRNAs type 1 diabetes mellitus (T1DM) not well investigated. In present study, we characterized plasma-derived expression profiles T1DM predict their potential function pathogenesis T1DM. Material Methods Exosomal lncRNA were detected by Illumina Hiseq platform (T1DM subjects N=10; age-, sex-...
Prolyl 4-hydroxylase, beta polypeptide (P4HB) protein has been found to be associated with tumorigenesis in many types of tumor, However, the relationship between P4HB and clear cell renal carcinoma (ccRCC) not clarified. In this study, we focus on correlation expression ccRCC. Through Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) our database immunohistochemical (IHC) staining. Compared adjacent normal tissues, both mRNA levels ccRCC tissues were enhanced. The...
Introduction: Bladder cancer is a lethal human malignancy. Currently, treatment for bladder limited. The anti-tumor effects of leflunomide have attracted much more concern in multiple cancers. Materials and Methods: This study evaluated the on cell viability, colony formation, apoptosis, cycle two carcinoma lines, 5637 T24. Meanwhile, underlying mechanism including PI3K/Akt signaling pathway autophagy modulation was also identified. Results: Leflunomide markedly inhibited growth both lines...
In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared. Bacterial cellulose (BC) physically chemically modified by laser hole forming selective oxidation to obtain the (DMBC). The soybean (SPI) compounded on DMBC DMBC/SPI better biocompatibility. used repair damaged urethra in rabbits. results showed that beneficial heal did...
Urethral stricture and reconstruction are one of the thorny difficult problems in field urology. The continuous development tissue engineering biomaterials has given new therapeutic thinking to this problem. Bacterial cellulose (BC) is an excellent biomaterial due its accessibility strong plasticity. Moreover, adipose-derived stem cells (ADSCs) could enhance their wound healing ability through directional modification.
OBJECTIVES: Preoperative decision-making for differentiating malignant from benign lesions in the gallbladder remains challenging. We aimed to create a diagnostic nomogram identify cancer (GBC), especially incidental GBC (IGBC), before surgical resection. METHODS: A total of 587 consecutive patients with pathologically confirmed hospital were randomly assigned training cohort (70%) and an internal validation (30%), 287 other centers as external cohort. Radiological features developed by...
Human renal cell carcinoma (RCC) is the most common type of kidney cancer that arises from epithelium. Up to 33.3% RCC patients treated with local tumor resections will subsequently develop recurrence or metastases. Thus, optimized therapeutic regimes are urgently needed improve prognosis RCC. Reversine was recently reported exert critical roles in therapy.This study evaluated anti-tumor effects reversine on viability, colony formation, apoptosis, and cycle 786-O ACHN lines.It demonstrated...