A5012813072- Ocular Oncology and Treatments
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- interferon and immune responses
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Calcium signaling and nucleotide metabolism
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Hedgehog Signaling Pathway Studies
- TGF-β signaling in diseases
Beijing Institute of Technology
2020-2025
Ministry of Industry and Information Technology
2023-2025
Aerospace Center Hospital
2024-2025
Peking University First Hospital
2024
Peking University
2024
Beijing Proteome Research Center
2022
Emory University
2014-2021
Children's Healthcare of Atlanta
2016-2021
Center for Cancer and Blood Disorders
2015-2017
Tianjin Medical University
2017
CircRNA is a novel type of RNA molecule formed by covalently closed loop which have no 5'-3' polarity and possess polyA tail relatively stable due to the cyclic structure. Therefore, they may serve as potential targets diagnosis biomarkers for tumor therapy. cZNF292 an important circular oncogenic plays critical role in progression tube formation. This study aimed at exploring human glioma formation its mechanism action. We found that silencing suppresses inhibiting cell proliferation cycle...
Abstract The mitochondrial GTPase mitofusin-2 (MFN2) has previously been reported to play a role in regulating cell proliferation, apoptosis and differentiation number of types. Here, we report that breast cancer patients with low MFN2 expression are associated poor prognosis as compared high expression. We find knockout from MCF7 A549 cells via Crispr/Cas9 greatly promotes viability, colony formation, invasion vitro vivo , which were confirmed by formation assay, transwell tumor xenograft...
Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined importance of hypoxia UM growth tested antitumor effects arylsulfonamide 64B, an inhibitor hypoxia-induced factor (HIF) pathway animal models investigated related mechanisms.UM cells were implanted uvea mice eyes systemically treated with 64B. Drug effect on primary eye tumor growth, circulating cells, metastasis formation liver, survival examined. 64B cell invasion expression C-X-C...
Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation. However, regulatory mechanisms of biomolecular condensates by key adaptor protein p62 via liquid-liquid phase separation (LLPS) remain obscure.In this study, we showed that E3 ligase Smurf1 enhanced Nrf2 activation and promoted autophagy increasing capability. Specifically, Smurf1/p62 interaction improved formation material exchange liquid...
Cancer cells consistently utilize the unfolded protein response (UPR) to encounter abnormal endoplasmic reticulum (ER) stress induced by accumulation of misfolded proteins. Extreme activation UPR could also provoke maladaptive cell death. Previous reports have shown that NRF2 antioxidant signaling is activated and serves as noncanonical pathway defense reduce excessive ROS levels during ER stress. However, mechanisms regulating upon in glioblastoma not been fully elucidated. Here we identify...
The high-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. deletions mutations of the tumor suppressor PTEN (5%-40%) in patients are associated with worse survival therapeutic resistance. Characterization unique prognosis molecular signatures status still unclear. This study established a novel risk model, screened optimal prognostic signatures, calculated score for individual different status. Screening results revealed fourteen independent PTEN-wt...
Macroautophagy/autophagy is a homeostatic process in response to multiple signaling, such as the lysosome-dependent recycling of cellular components. Starvation-induced MTOR inactivation and PPP3/calcineurin activation were shown promote nuclear translocation TFEB. However, mechanisms via which signals from endomembrane damage are transmitted activate orchestrate autophagic responses remain unknown. This study aimed show that autophagy regulator SMURF1 controlled TFEB import for...
LncRNA-LET, a recently identified long noncoding RNA, has been shown to act as tumor suppressor; however, its biological function and mechanism have not fully investigated. Our research found that there was less expression of LET in nasopharyngeal carcinoma (NPC) tissues than normal might inhibit proliferation, adhesion invasion NPC vitro by enhancing expression. By contrast, decreased could promote the NPC. In addition, profiles related genes MAPK/ERK pathway were also regulated effectively...
Previous studies have demonstrated the in vitro oncogenic role of protein arginine methyltransferase 5 (PRMT5) gastric cancer cell lines. The vivo function PRMT5 tumorigenesis, however, is still unexplored. Here, we showed that Prmt5 deletion mouse epithelium resulted spontaneous tumorigenesis antrum. All Prmt5-deficient mice displayed intestinal-type within 4 months age. Of note, 20% (2/10) mutants finally developed into invasive by 8 Gastric caused loss exhibited increase Lgr5+ stem cells,...
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) has been implicated in intimal hyperplasia, atherosclerosis restenosis following percutaneous coronary intervention. Formononetin, a phytoestrogen extracted from the root Astragalus membranaceus, widely used Chinese tradition medicine due to its protective effects against certain symptoms cancer, hypertension, inflammation, hypoxia-induced cytotoxicity ovariectomy-induced bone loss. However, effect formononetin on...
K63-linked polyubiquitination of the neurodegenerative disease-associated misfolded protein copper-zinc superoxide dismutase 1 (SOD1) is associated with formation inclusion bodies. Highly expressed E3 ligase Smad ubiquitylation regulatory factor (Smurf1) promotes cellular homeostasis through enhanced capability aggregate degradation. However, it not well explored role Smurf1 in dynamics SOD1 aggresomes. In this study, we report that recruitment to form Mechanistically, interacts mutant...