A5100681608- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Financial Literacy, Pension, Retirement Analysis
- Primary Care and Health Outcomes
- interferon and immune responses
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Health, psychology, and well-being
- Epilepsy research and treatment
- Energy, Environment, Economic Growth
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Healthcare Systems and Reforms
- Neuroscience and Neuropharmacology Research
- Fiscal Policy and Economic Growth
- School Health and Nursing Education
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Cardiovascular Syncope and Autonomic Disorders
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
- Integrated Energy Systems Optimization
- S100 Proteins and Annexins
- Multiple Sclerosis Research Studies
Central South University
2013-2025
Second Xiangya Hospital of Central South University
2012-2025
Beijing Institute of Technology
2020-2024
Shihezi University
2023-2024
Taiyuan University of Science and Technology
2008-2024
Jiangsu University
2024
Army Medical University
2023
Southwest Hospital
2023
Xiangya Hospital Central South University
2015-2022
Guangdong University of Technology
2022
Melatonin is an indoleamine secreted by the pineal gland as well a plant-derived product that exerts potential anti-inflammatory properties, but mechanisms of action remain unclear. Here, we investigated roles melatonin in regulation proinflammatory mediators and identified underlying human vascular smooth muscle (VSM) cell line CRL1999 stimulated lipopolysaccharide (LPS). We found treatment with significantly inhibited production expression TNF-α interleukin (IL)-1β, cyclooxygenase-2...
Aims Epilepsy is a neurological disease occurring worldwide. Alterations in the gut microbial composition may be involved development of Epilepsy. The study aimed to investigate effects cannabidiol (CBD) on microbiota and metabolic profile epileptic rats. Materials methods results A temporal lobe epilepsy rat model was established using Li-pilocarpine. CBD increased incubation period reduced state Compared rats, M1/M2 ratio microglia group significantly decreased. expression IL-1β, IL-6,...
Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation. However, regulatory mechanisms of biomolecular condensates by key adaptor protein p62 via liquid-liquid phase separation (LLPS) remain obscure.In this study, we showed that E3 ligase Smurf1 enhanced Nrf2 activation and promoted autophagy increasing capability. Specifically, Smurf1/p62 interaction improved formation material exchange liquid...
In the face of increasing global unsustainable risks such as poverty, hunger, and pollution. Building sustainable agriculture (SA) in digital age is a fundamental task for human survival. Based on coupled coordination perspective, this paper constructs an SA system that takes into account more stakeholders by considering poverty alleviation income increase (PI), food security (FS), green (GA) subsystems. The impact technology systematically analyzed through data from 276 prefecture-level...
Background Increasing evidence has suggested that major depression ( MD ) is associated with an increased risk of ischemic heart disease IHD ). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million aged 30 to 79 years were followed baseline interview (2004–2008) until December 31, 2013. Past year was measured modified version Composite International Diagnostic Interview‐Short Form at baseline. Incident cases...
The high-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. deletions mutations of the tumor suppressor PTEN (5%-40%) in patients are associated with worse survival therapeutic resistance. Characterization unique prognosis molecular signatures status still unclear. This study established a novel risk model, screened optimal prognostic signatures, calculated score for individual different status. Screening results revealed fourteen independent PTEN-wt...
Abstract One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is lack understanding underlying mechanisms that are commonly associated with blood-brain barrier (BBB), which mainly consists brain microvascular endothelial cells (BMEC). Here, we hypothesized Glycoprotein 120 (gp120), methamphetamine (METH) nicotine (NT) can enhance amyloid-beta (Aβ) accumulation BMEC through Alpha7 nicotinic acetylcholine receptor (α7...
Background Dermatomyositis is an autoimmune disease characterized by damage to the skin and muscles. CD4 + T cells are of crucial importance in occurrence development dermatomyositis (DM). However, there few bioinformatics studies on potential pathogenic genes immune cell infiltration DM. Therefore, this study intended explore T-cell infiltration–associated key DM construct a new model predict level Methods GSE46239, GSE142807, GSE1551, GSE193276 datasets were downloaded. The WGCNA CIBERSORT...
After successful pilot projects, Zhejiang Province, China, decided to systematically scale-up health promoting schools (HPS) over the entire province of 47 million. This study describes interventions and self-reported changes in attitudes, knowledge behavior during first phase scaling-up. Group interviews were conducted with a sample 191 participants (school administrators, teachers, students parents) from nine total ∼15 200 students. Grounded theory guided data analysis. Schools implemented...
Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, effect of on process human osteoblasts (hOBs) apoptosis still unclear. In this study, we detected function serum-free-induced cell using ELISA TUNEL arrays then found mortality hOBs was significantly decreased after exposure 10(-10)-10(-6) M...
Cryptococcal meningitis is the most common fungal infection of central nervous system (CNS) in HIV/AIDS. HIV-1 virotoxins (e.g., gp41) are able to induce disorders blood-brain barrier (BBB), which mainly consists BMEC. Our recent study suggests that α7 nAChR an essential regulator inflammation, contributes regulation NF-κB signaling, neuroinflammation and BBB caused by microbial gp120) non-microbial [e.g., methamphetamine (METH)] factors. However, underlying mechanisms for multiple...