A5100361420- Retinoids in leukemia and cellular processes
- Autoimmune and Inflammatory Disorders
- Invertebrate Immune Response Mechanisms
- Forensic and Genetic Research
- Nanoparticles: synthesis and applications
- Inflammasome and immune disorders
- Advancements in Transdermal Drug Delivery
- Antifungal resistance and susceptibility
- Identification and Quantification in Food
- Bone Tissue Engineering Materials
- Psoriasis: Treatment and Pathogenesis
- Parasites and Host Interactions
- Cell Adhesion Molecules Research
- Forensic Entomology and Diptera Studies
- Actinomycetales infections and treatment
- RNA regulation and disease
- Marine Sponges and Natural Products
- Genetic Associations and Epidemiology
- Polysaccharides and Plant Cell Walls
- Skin Diseases and Diabetes
- Immunotoxicology and immune responses
- Aquaculture disease management and microbiota
- Mesenchymal stem cell research
- Hidradenitis Suppurativa and Treatments
- Parasite Biology and Host Interactions
Southern Medical University
2007-2024
Nanfang Hospital
2007-2024
Beijing Children’s Hospital
2021
Capital Medical University
2021
Second Xiangya Hospital of Central South University
2017
Central South University
2017
Purpose: Zinc oxide nanoparticles (ZnO-NPs) have exerted antimicrobial properties. However, there is insufficient evaluation regarding the in vivo antifungal activity of ZnO-NPs. This study aimed to investigate efficacy and mechanism ZnO-NPs controlling Candida albicans invertebrate Galleria mellonella. Methods:Galleria mellonella larvae were injected with different doses determine their toxicity. Non-toxic chosen for prophylactic injection G. followed by C. infection. Then direct vitro...
Abstract One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is lack understanding underlying mechanisms that are commonly associated with blood-brain barrier (BBB), which mainly consists brain microvascular endothelial cells (BMEC). Here, we hypothesized Glycoprotein 120 (gp120), methamphetamine (METH) nicotine (NT) can enhance amyloid-beta (Aβ) accumulation BMEC through Alpha7 nicotinic acetylcholine receptor (α7...
Abstract Background New therapeutics are urgently needed for infectious diseases, especially the fungal infection like Fonsecaea monophora . Photodynamic therapy has been showing antimicrobial activity on some pathogens. The combination of medicines and photodynamic (PDT) might be a practical approach. However, whether treatment PDT could do benefits to host immunity remains poorly documented. Results In this study, Galleria mellonella larvae were employed as model organism evaluate PDT,...
Commensal fungi are an important part of human microbial community, among which Candida albicans and glabrata two common opportunistic pathogens. Unlike the high pathogenicity C. albicans, is reported to show low host. Here, by using a Galleria mellonella infection model, we were able confirm much lower virulence than albicans. Interestingly, pre-exposure live (LCG) protects larvae against subsequent various lethal fungal infections, including tropicalis, Cryptococcus neoformans....
Internal and external factors cause various types of wounds on the skin. Infections, nonhealing chronic wounds, aesthetic functional recovery all challenges for clinicians. The development nanotechnology in biomedicine has brought many new materials, methods therapeutic targets treatment which are believed to have great prospects. In this work, nanomaterials applied different stages promote wound healing systematically expounded their mechanisms were reviewed. Then, difficulties defects...
Abstract Zinc oxide nanoparticles (ZNPs) are widely used in sunscreens and nanomedicines, it was recently confirmed that ZNPs can penetrate stratum corneum into deep epidermis. Therefore, is necessary to determine the impact of on In this study, were applied mouse skin at a relatively low concentration for one week. As result, desmosomes epidermal tissues depolymerized, mechanical strain resistance reduced, levels desmosomal cadherins decreased cell membrane lysates increased cytoplasmic...
Syphilis is a chronic systemic infectious disease involving multiple organs. Involvement of skeletal system by syphilis including osteochondritis, osteoarthritis, periostitis, and osteitis. Charcot arthropathy an unusual concomitant syphilis, the incidence had decreased significantly these decades. The present authors report case presenting with bilateral ankle joints.
We reported the successful treatment with oral methylprednisolone and cyclosporine in combination topical wound care on a boy pyoderma gangrenosum presenting as huge deep ulceration buttocks legs.
Data sharing is not applicable to this article as no new data were created or analyzed in study.
Aim: To investigate the genetic polymorphisms of 19 STR loci in Teochew population Chaozhou.Subjects and methods: Nineteen 631 unrelated people Chaozhou were detected by using AGCU Expressmarker 20 kit.Results: The allele frequency ranged from 0.0008–0.5577. combined power discrimination probability excluding paternity is over 0.999,999,999,999,999,999,999,999,999,999 0.999,999,992,549,546, respectively. principal component analysis based on 11 shared showed was most genetically related to...
Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It mainly caused by autoantibodies against hemidesmosomal proteins-bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported case PG polycystic ovary syndrome (PCOS). This patient received assisted reproduction technology suffered her To best our knowledge, there no similar has been reported.
Abstract: The rare disease of chronic infantile neurological cutaneous and articular (CINCA) syndrome, is caused by the over-secretion interleukin (IL)-1β due to a gain-of-function NLRP3 gene mutation in autosomal chromosome which often involves eyes. In this report, we studied 9-year-old girl with CINCA. eyes were also involved presented bilateral papilledema. Genetic testing revealed that symptoms novel site (c.913G>A, p. D305N) conservative domain exon-3 gain-function patient had...